Prolapse and Incontinence Flashcards

1
Q

What are the 3 levels of vaginal support anatomically?

A
  1. Cervix and upper 1/3 of the vaginal are supported by the cardinal (transverse cervical) and uterosacral ligaments. These attach from the cervix to the pelvic sidewalls and sacrum respectively.
  2. Mid portion of the vaginal is supported by endofascial condensations (endopelvic fascia) laterally to the pelvic side walls.
  3. Lower 1/3 of the vagina is supported by the levator ani muscle and the perineal body. The levator ani and its fascia are termed the pelvic diaphragm.
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2
Q

What is the pelvic floor, and what pierces through it?

A

The pelvic floor supports the pelvic organs and is pierced by the urethra and vagina termed the urogenital hiatus and rectum – the rectal hiatus. Between these two hiatuses lies a fibrous node known as the perineal body which joins the pelvic floor to the perineum.

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3
Q

Describe the levator ani muscle?

A

The levator ani muscle forms a broad muscular sheath and forms the main part of the pelvic floor; it is formed by the puborectalis, pubococcygeus, and iliococcygeus muscle. It attaches to the pubic bone anteriorly, ischial spines posteriorly, and the tendinous arch of levator ani laterally. It is innervated by the nerve roots S2, 3 and 4.
• Puborectalis loops around the anal canal to provide both faecal and urinary continence and must relax to allow for micturition or defecation.
• Pubococcygeus this is the main constituent of the levator ani and some of its fibres loops down around the prostate and vagina (levator prostate and pubovaginalis)
• Iliococcygeus thin muscle fibres comes from the ischial spine and attach posteriorly at the coccyx

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4
Q

Describe the coccygeus muscle

A

The coccygeus muscle arises from the ischial spine and runs to the inferior sacrum and coccyx; their fleshy fibres lie on and attach to the sacrospinous ligament.

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5
Q

What are the risk factors for prolapse?

A

Advancing Age
Menopause – low oestrogen causes atrophy of collagenous connective tissue
Parity
Connective tissue diseases such as Ehlers-Danlos
Smoking
Any chronic condition that increases intra-abdominal pressure e.g. chronic cough, obesity, constipation, heavy lifting and pelvic masses
Surgery – hysterectomy and continence procedures

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6
Q

How are prolapses classified?

A

Cystocele – prolapse of the anterior vaginal wall involving the bladder. If urethra involved, then cysto-urethrocele.
Uterine-apical prolapse – uterus, cervix and upper vagina
Enterocele – upper posterior wall of the vagina. Resulting pouch can contain bowel loops
Rectocele – lower posterior wall of the vagina involving the anterior wall of the rectum
Vaginal vault prolapse - prolapse of the superior portion of the vagina following a hysterectomy

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7
Q

Describe the grading of a prolapse?

A

Grading – Baden-Walker classification
Grade 1 – prolapse descends halfway down the vaginal axis to the introituse
Grade 2 – prolapse descends to the level of the introituse and through it when straining
Grade 3 – prolapse descends through the introituse and lies outside the vagina

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8
Q

Describe how a prolapse usually presents and its clinical features

A

Asymptomatic
Obvious prolapse
Pain and backache
Digitation – having to hold fingers on an area to prevent prolapse when on toilet
Bleeding or discharge
Dyspareunia or Apareunia – inability to have sex
Difficulty inserting tampons
Urinary symptoms e.g. frequency, urgency, incomplete bladder emptying
Constipation and difficulty defecation
High grade may result in ulceration, bleeding and discharge

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9
Q

How should a prolapse be investigated and examined?

A
Full gynae examination 
USS for pelvic masses 
Urodynamics if incontinence 
Assess pelvic floor strength 
Assessment for surgery
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10
Q

What should be considered when deciding whether to manage prolapses conservatively or with surgery?

A

Decision of which management to use should consider symptoms, age, parity, wish for further pregnancies and sexual activity.

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11
Q

Describe conservative management options for prolapse

A

If its not bothering them this is generally the best course of action
Weight loss and cessation of smoking
Treat underlying illnesses such as chronic cough and constipation
Pelvic floor exercises and physio
Pessaries to reduce prolapse – easy and effective with minimal side effects
Types of pessary: ring, shelf and cube and doughnut

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12
Q

Describe different surgical options for treating prolapse

A

• Anterior compartment defect – anterior repair (anterior colporrhaphy) usually for cysto-urethrocele or paravaginal repair (abdominal approach).
• Posterior compartment defect – posterior repair (posterior colporrhaphy) for rectocele or deficient perineum
• Uterovaginal prolapse
a. Hysterectomy
b. Sacrohysteropexy (If patient wishes to preserve uterus)
• Vaginal vault prolapse
a. Sacrospinous ligament fixation
b. Sacrocolpoplexy

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13
Q

What are the complications of prolapse surgery

A
Recurrent prolapse 
Haemorrhage and vault haematoma 
Vault infection 
DVT
New incontinence 
Ureteric or bladder injury
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14
Q

Which nerves are involved in controlling continence?

A

S2, 3 and 4 – pudental nerve and parasympathetic controlling detrusor pressure and somatic nerves controlling the external sphincter
T12 – L2 – sympathetic controlling the internal sphincter

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15
Q

How does the level of the sphincters of the bladder effect continence?

A

Sphincters of the bladder normally lie above the pelvic floor and so are subject to intra-abdominal pressure however if they fall below this it can lead to incontinence.

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16
Q

Define urgency and urge incontinence?

A

Urgency – overwhelming desire to void

Urge incontinence – urgency associated with leakage

17
Q

Define stress incontinence

A

Stress incontinence – leak when coughing, sneezing etc.

18
Q

Define frequency

A

Frequency – voiding >8 times per day

19
Q

Define Nocturia

A

Nocturia – voiding > 2 per night making up 1/3 of total diurnal volume

20
Q

Define hesitancy

A

Hesitancy – delay in commencing stream

21
Q

Define dysuria

A

Dysuria – burning discomfort while/after voiding

22
Q

What are the risk factors for urinary incontinence in women?

A
  • Pregnancy and Deliveries
  • Advancing Age
  • Menopause due to low oestrogen
  • High BMI
  • Hysterectomy
  • Family History
23
Q

What investigations are available for incontinence?

A

Urinalysis – check for infection – false diagnosis risk

Diaries – 3-7 days, assess intake and outtake – fluid volume chart

Pad tests to look at leakage (not very reliable, 24-hour home tests best). Outcome response to conservative treatment 
•	0-20g – excellent
•	21-50g – good 
•	51-75g – moderate
•	>75g – likely to require surgery

Residual volume check either by USS or catheterisation

Cystometry (Urodynamic studies) – measure abdominal and bladder pressure whilst artificially filling and voiding

Ultrasound/Intravenous pyelogram (IVP) for renal tract abnormalities

Cystoscopy for blood, recurrent UTIs, fistula or bladder pain
Vaginal examination to rule out prolapse and assess ability to contract pelvic floor (Kegel’s)

Urinary dye studies

24
Q

What can cause urinary incontinence?

A
  • Urodynamic stress incontinence – prolapse, pelvic floor tone
  • Detrusor overactivity – urgency/overactive bladder syndrome
  • Overflow incontinence – leakage of urine from very full bladder without any urge to go. Usually due to bladder outlet obstruction e.g. due to prostate enlargement or injury from surgery. Bladder simply leaks when it is full.
  • Abdominal masses occupying space that bladder otherwise would
  • Bladder fistulae or urethral diverticulum
  • Multiple Sclerosis
  • Drugs – diuretics and timings
25
Q

What should be the general management of all types of incontinence?

A

Sensible fluid intake – 1.5-2L avoiding tea, coffee and alcohol
Downstairs toilets, pads, bedpans and commodes etc.

26
Q

What causes urodynamic stress incontinence?

A

Incompetent urethral sphincter – childbirth, menopause, prolapse, chronic cough and rarely sphincter inadequacy. Most people have positional displacement i.e. movement of the sphincter below pelvic floor, few people have intrinsic weakness. Prolapse is often present and asking the patient to cough may demonstrate the incontinence.

27
Q

What will be found on investigation for urodynamic stress incontinence?

A

Normal bladder capacity, leakage in absence of detrusor pressure rise and provoked by cough causing a small to moderate loss.

Main Investigations: urinalysis, frequency/volume charts and urodynamics

28
Q

How should urodynamic stress incontinence be managed?

A

Conservative
Lifestyle changes – weight loss and smoking cessation
Treatment of risk factors i.e. chronic cough
Physiotherapy – simple no side effects but requires patient motivation – success 50-75%

Medical
Duloxetine majority report 50% improvement side effects – N and V. Useful after surgery or for those that surgery is not suitable.

Surgery
1st year 95% success rate, long term – 85%
1. Tension free vaginal tape (TVT) to bring sphincters above pelvic floor. 85% 1 year and 5-year success rate. Possible side effects – voiding difficulty, bladder injury and detrusor overactivity. Also Transobturator tape (TOT) – less risk to bladder but more risk of nerve trauma.
2. Burch colposuspension -95% 1 year and 75% 10-year cure rate. Side effects voiding difficulty, detrusor overactivity, bladder injury and posterior prolapse formation
3. Laparoscopic colposuspension similar to above
4. Periurethral injection – good for intrinsic sphincter problems. Collagen or silicone PVC. 50-75% success after one treatment and can be repeated. Good for older patients not suitable for surgery

29
Q

What is detrusor over activity or urgency incontinece?

A

Uncontrolled and unprovoked detrusor muscle activity – pressure exceeds sphincter tone. Often occurs in people with a history of childhood UTIs. May occur as a new problem following stress incontinence surgery. Usually few findings, may be leakage on cough (stimulating detrusor) or sometimes signs of nervous system involvement e.g. multiple sclerosis. Often also frequency and nocturia and urge may to brought on by triggers such as running water and washing hands.

30
Q

What is found on investigation of suspected detrusor overactivity?

A

Cystometry findings
Reduced bladder capacity and leakage with detrusor pressure rise. Often this is a large loss compared to stress where it is small.

Main Investigations: urinalysis, frequency/volume charts and urodynamics (essential for diagnosis)

31
Q

How should destrusor over activity be managed?

A

Conservative
Fluid intake management
Behaviour therapies – bladder drills (training), alarms and timers. Gradually increase time between voiding

Medical
Mainstay treatment is antimuscarinics are first line (Oxybutynin and Tolterodine and Darifenacin) but low efficacy, poor compliance due to side effects – dry mouth, blurred vision and constipation. Slow release preparations better. Avoid Oxybutynin immediate release in frail old women, Mirabegron (beta 3 agonist) may be used if worried about side effects). Contraindications: acute glaucoma, myasthenia gravis, urinary retention, severe UC and GI obstruction.
• Intravaginal oestrogens for those with vaginal atrophy
• Botulinum toxin
• Electrical stimulation – high frequency applied to the S3 nerve root (75% success) but often must be repeated. Can also

Surgery (reserved for debilitating symptoms only)

  1. Detrusor myomectomy and Clam enterocystoplasty – requires self-catheterisation and some malignancy risk
  2. Urinary diversion – ileostomy and continent reservoir diversions
32
Q

How should mixed incontinence be managed?

A

Both detrusor over activity and stress incontinence.

Management
Individualised discussions, conservative measured for stress. Can consider surgery but urgency persists in 70%.