Project progression and milestones

Question 1

1 Target selection

Answer 1

Project initiated and strategy for generating compounds is agreed

Question 2

2 Lead generation investment

Answer 2

• First round of approaches to find lead compounds and positive evidence for project doability
• Target validation strengthened
• Plan to identify patient

Question 3

3 Lead optimisation

Answer 3

• One or more series of compounds
• Candidate compound selection
• Target validation in vitro/in vivo
• Screening cascade

Question 4

4 Candidate drug investment

Answer 4

• Found the best compound
• Test mechanism in patients
• And believe that it is safe