Progestins

Question 1

Norethindrone and norethindone acetate

estrogenic?
progestational?
androgenic?

Answer 1

estrogenic: ++
progestational: ++
androgenic: ++

1st gen

Question 2

norgestrel

estrogenic?
progestational?
androgenic?

Answer 2

estrogenic: 0
progestational: +++
androgenic: +++

1/2 gen

Question 3

levonorgestrel

estrogenic?
progestational?
androgenic?

Answer 3

estrogenic: 0
progestational: ++++
androgenic: +++

2nd gen

Question 4

norgestimate

estrogenic?
progestational?
androgenic?

Answer 4

estrogenic: 0
progestational: ++
androgenic: ++

3rd gen

Question 5

desogestrel

estrogenic?
progestational?
androgenic?

Answer 5

estrogenic: +/-
progestational: ++++
androgenic: ++

3rd gen

Question 6

drospirenone

estrogenic?
progestational?
androgenic?

Answer 6

estrogenic: 0
progestational: +/-
androgenic: 0

4th gen

Question 7

Segesterone acetate

estrogenic?
progestational?
androgenic?

Answer 7

estrogenic: 0
progestational: +/-
androgenic: 0

Question 8

Raises HDL and lowers LDL?

Answer 8

norethindrone and norethindone

1st gen

Question 9

Androgenic ADRs are common (acne, hirsutism)?

Answer 9

norgestrel

1/2 gen

Question 10

Most widely prescribed?

Answer 10

levonorgestrel

2nd gen

Question 11

Negative impact on lipids?

Answer 11

levonorgestrel

2nd gen

Question 12

Used for emergency contraception?

Answer 12

levonorgestrel

2nd gen

Question 13

Associated with a slightly increased risk of thrombosis?

Answer 13

norgestimate, desogestrel

3rd gen

Question 14

FDA approved for acne?

Answer 14

norgestimate

3rd gen

Question 15

Higher risk of blood clots according to FDA?

Answer 15

drospirenone

4th gen

Question 16

Structurally similar to K+ sparing diuretic?

Answer 16

drospirenone

decreased bloating, weight gain, PMS symptoms

4th gen

Question 17

Can cause hyperkalemia?

Answer 17

drospirenone

4th gen

Question 18

FDA approved for PMDD?

Answer 18

drospirenone

4th gen

Question 19

Newly FDA approved in one year ring product?

Answer 19

segesterone acetate

4th gen

Question 20

AEs associated with progestins:

bloating

estrogenic?
progestational?
androgenic?

Answer 20

estrogenic

Question 21

AEs associated with progestins:

nausea/vomiting

estrogenic?
progestational?
androgenic?

Answer 21

estrogenic

Question 22

AEs associated with progestins:

breakthrough bleeding

estrogenic?
progestational?
androgenic?

Answer 22

estrogenic

Question 23

AEs associated with progestins:

irritability

estrogenic?
progestational?
androgenic?

Answer 23

estrogenic

Question 24

AEs associated with progestins:

headache

estrogenic?
progestational?
androgenic?

Answer 24

estrogenic and progestational

Question 25

AEs associated with progestins: hypertension estrogenic? progestational? androgenic?

Answer 25

estrogenic and progestational

Question 26

AEs associated with progestins: breast pain/tenderness estrogenic? progestational? androgenic?

Answer 26

progestational

Question 27

AEs associated with progestins: Acne/oily skin estrogenic? progestational? androgenic?

Answer 27

androgenic

Question 28

AEs associated with progestins: weight gain estrogenic? progestational? androgenic?

Answer 28

androgenic

Question 29

AEs associated with progestins hirsutism estrogenic? progestational? androgenic?

Answer 29

androgenic

Question 30

AEs associated with progestins: fatigue estrogenic? progestational? androgenic?

Answer 30

androgenic

Question 31

AEs associated with progestins: depression estrogenic? progestational? androgenic?

Answer 31

androgenic