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PR - GENITO-URINARY TRACT SYSTEM > PROGESTERONE ONLY PILL (POP) > Flashcards

PROGESTERONE ONLY PILL (POP) Flashcards

1
Q

MOA of POC

A

1) thickening of the cervical mucus
2) suppression of ovulation
3) changes in the uterine lining

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2
Q

Formulation

A

Parenteral
PO

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3
Q

Side effects

A

Menstrual irregularities
- Heavy/light periods (common)
- Irregular periods
- Prolonged periods
Cancer
- Increased risk of breast cancer
- weight increase
- breast tenderness
- libido changes
- mood changes
- ovarian cysts
- skin reactions

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4
Q

How to take

A

OD on a continuous basis
Start on day 1 of cycle
Take at same time each day
If started after day 5 of menstrual cycle = use extra protection for 2 days

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5
Q

What additional precautions need to be taken with POCs?

A

No additional precautions needed if started within first 5 days of cycle
Need 2 days precaution if taken after that

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6
Q

Missed pill - when can you take

A

Can take within 3 hours
Desogestrel = 12 hours
- ASAP
- usual time (can mean 2 in a day)
- Need protection till 48 hours of pills are taken correctly (7 for desogestrel)
- Need emergency contraception if UPSI happened between missed pill and 2 days after restarting medication

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7
Q

Drugs which interact with POC

A
  • Griseofluvin - effectiveness of POP may be reduced
  • Ulipristal - effectiveness may be reduced
  • REMEMBER ‘CRAPPS’ ENZYME INDUCERS! Carbamazepine, Rifampicin, Aprepitant, Phenytoin, Phenobarbital,
  • St John’s Wort - reduce effectiveness of POPs
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8
Q

What should be done if a patient is taking a progesterone-only pill alongside an enzyme-inducing drug e.g., carbamazepine or phenobarbital?

A

additional barrier method is recommended, during taking and for 28 days after!

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8
Q

POC injection

A

Depot medroxyprogesterone acetate
99.8% effective in correct usage
every 13 weeks

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9
Q

How effective is the depo injection?

A

99.8% effective in correct usage

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10
Q

How long does the depo injection last?

A

3 months

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11
Q

Side effects of depo injection

A
  • Loss of bone density may occur
  • Delayed return to fertility of up to one year after treatment cessation
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12
Q

POC Implant

A

Etonogesterel (Nexplanon)
99.95% effective in correct usage
* Lasts up to 3 years
MHRA Warning: neurovascular injury and migration of the implant - remove ASAP

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13
Q

How effective is nexplanon

A

99.95% effective in correct usage

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14
Q

How long does nexplanon last?

A

3 years

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15
Q

MHRA Warning: nexplanon

A

neurovascular injury and migration of the implant - remove ASAP

PR - GENITO-URINARY TRACT SYSTEM (12 decks)

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