Professionalism Flashcards
1
Q
What are the different types of treatment intent?
A
1) Radical (curative) e.g. chemotherapy for testicular cancer
2) Neoadjuvant: used prior to e.g. surgery
3) Adjuvant: used after e.g. surgery
4) Palliative: used for symptom relief
5) Clinical trials
For haematological cancers may refer to treatment phases
- Induction: induce remission
- Consolidation: complete remission
- Intensification: extend remission
- Salvage: regain remission
- Maintenance: retain remission
2
Q
What’s the most widely used method of calculating doses?
A
DuBois and DuBois
BSA (m2) = (W^0.425 x H^0.725 x 71.84) / 10,000
3
Q
Tell me about AUC
A
- individual dosing strategy based on GFR - mainly used for carboplatin
- efficacy and toxicity correlates with AUC
high AUC = toxicity
low AUC = reduced therapeutic effect
AUC calculated from plasma conc (mg/l) against time in hours
