Problem Set Flashcards
1
Q
What cytochrome p450 breaks down acetaminophen to a toxic drug in the liver?
A
CYP3A4
2
Q
What cytochrome p450 modifies warfarin?
A
CYP2C9
Warfarin hydroxylated to increase excretion.
3
Q
What step in drug metabolism do the cytochromes
p450s perform?
A
- phase I
- addition of a polar group to a drug to increase its rate of excretion from the body
4
Q
Genetic variation in VKORC1 can be used to
determine dosing requirements for which medication?
A
Warfarin
- VKORC1 (vitamin K epoxide reductase) is the target of Warfarin.
- Warfarin inhibits regeneration of reduced Vitamin K, which is necessary for the clotting cascade.
5
Q
Pharmacokinetics =
A
what the body does to a drug
metabolism, excretion, etc.
6
Q
Pharmacodynamics =
A
what a drug does to the body
active site of drug
7
Q
Genome-wide association studies can be used to identify:
A
- new genes which may not have been previously implicated in modulating gene response.
- A list of candidate genes is not necessary.
