PRINCIPLES OF SURGICAL IMMUNOLOGY AND ORGAN TRANSPLANTATION

Question 1

Transplant terminology and definitions

Autografts
Isografts
Allograft
Xenotransplantation
Orthotopic transplantation
Heterotropic transplantation
Auxillary graft
Auxillary partial orthoptic liver transplantation

Question 2

The Immune Responses Involved in Transplantation

Tabulate the MHC 1 and 2
Name cells and functions

Pathophysiology of cell death ?

Most common viral disease post RT?

Answer 2

Question 3

Define organ rejection
Diagnosis?
Name 3 types ? classify by time

Answer 3

Hyperacute
Acute
Chronic

Question 4

• Immunosuppression Drugs in use
  Name 4 groups and MOA

Classify drugs 3 goups

What drugs used locally?

Answer 4

Induction
Maintenance
Rescue

Question 5

Common side effects ?

Explain risk of Cancer ?

Question 6

General CI donor ?

Answer 6

General contraindications
 Age <10 - >75 years
 Body weight < 5 kg or a BMI > 50 kg/m2
 Previous haematological malignancies and/or malignant neoplasms with active metastasis.
 Active fungal, parasitic, viral, or bacterial meningitis or encephalitis
 Aplastic anaemia, agranulocytosis
 No discernible cause of death
* Kidney contraindications
 Age > 70 years; age 50-69 years with history of Type 1 diabetes for >20 years
 Polycystic kidney disease, glomerulosclerosis greater than or equal to 20% by kidney biopsy
 Terminal serum creatinine greater than 4.0 mg/dL
 Chronic renal failure
 No urine output for 24 hours or longer
* Liver contraindications:
 Cirrhosis, portal hypertension, fulminant hepatic failure
 Terminal total bilirubin greater than or equal to 4 mg/dL
 Macrosteatosis greater > 50% or fibrosis greater than or equal to stage II
 Terminal AST/ALT levels > 700 U/l

Question 7

How does retrieval differ between DBD and DCD?

Question 8

List end stage liver diseases that warrants Liver transplant?

Question 9

List complications of RT?

Question 10

Brain death testing :

Give prerequisites ?

Describe tests?

Describe apnee test ?

Answer 10