Principles Of Solubilty

Question 1

Define solubility and explain its process

Answer 1

Solution:

• A solution us a mixture of at least two components one of which is a solute (e.g. drug or Active Pharmaceutical ingredient (API)) and the other a solvent (e.g. water).
• a solution is a system in which molecules of solutes are dispersed in a solvent vehicle
  
  • solid particles in water do not match this definition

Question 2

Describe which factors/parameters affect the drugs solubility

Answer 2

• solid state of the drug (amorphous,crystalline)
• polymorph type
• salts and counter ions/common ion effect
• composition of aqueous media (composition of buffer)
• pH (buffer components)
• iconography strength of the solution
• temperature : an increase in temperature usually results in an increase in solubility but it is not always true

Question 3

Demonstrate understanding of miscibility

Answer 3

Misibility refers to the mutual solubilities of the compinents in liquid liquis systems