Principles of Immunology and Transplantation

Question 1

what test is done to dermine the presence of non-complement antibodies & quantify the risk of rejection?

Answer 1

Panel reactive Abs

Question 2

what are the 3 responses produced by the immune system?

Answer 2

signal 1: T cell activation & progression from G0 - G1
signal 2: co-stimulatory pathway
signal 3: cytokine stimulation from the G1 build up

Question 3

what are the clinical rejection syndromes?

Answer 3

hyperacute rejection
accelerated/antibody mediated rejection
acute rejection
chronic rejection

Question 4

what type of clinical rejection is a secondary response to pre-formed complement binding Ab that lasts for <24 hrs?

Answer 4

hyperacute rejection

Question 5

what type of clinical rejection has a hemorrhage & uses Panel Reactive Abs to determine the risk of rejection + lasts for 2-4 days?

Answer 5

Accelerate/antibody mediated rejection

Question 6

what type of clinical rejection is a primary T cell response & u can see infiltration of PMN + lasts >4days?

Answer 6

acute rejection

Question 7

What type of clinical rejection has vascular smooth muscle cell proliferation and lasts for >60 days?

Answer 7

chronic rejection

Question 8

What are aboslute C/Is of End-stage organ diseases?

Answer 8

• recently treated cancer other than SCC & Basal cell carcinoma
• <1 yr life expectancy
• Hepa B or C
• severe ischemic cadiac disease
• severe peripheral vascular disease

Question 9

What are relative C/Is of end-stage organ disease?