principles of drug action adrenergic agents exam 2

Question 1

Seizure

Answer 1

Uncontrolled, abnormal, synchronous firing of a group of neurons in the brain

A discrete clinical event

Symptom of underlying CNS dysfunction

Question 2

Distinct isolation of electrical activity is achieved through a

Answer 2

balance between excitatory and inhibitory neurotransmission

Ex: glutamate (excitatory); GABA (inhibitory)

Question 3

Synchronous activity in brain

Answer 3

Dysregulation of ion channels (voltage-gated sodium channels) and neural networks (GABA-mediated surround inhibition)

Question 4

Neural Networks

Answer 4

Restrict the propagation of an action potential to a defined region of the brain through surround inhibitionNeuron firing activates surrounding neurons:

Interneurons transmit inhibitory signals (GABA)

GABA inhibits other surrounding neurons

Question 5

Classification of Seizure

2 main groups

Answer 5

Partial/Focal: onset is localized and identifiable

Simple Partial

Complex Partial

Partial seizures can become secondarily generalized

Generalized: no evidence of localized onset

Tonic-clonic (grand mal)

Absence (petit mal)

Atonic, tonic, myoclonic