Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Antimicrobial Therapy > Principles of Antimicrobial Therapy > Flashcards

Principles of Antimicrobial Therapy Flashcards

1
Q

Penicillin MOA

A

Inhibits cell wall synthesis by binding to and inhibiting PBPs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cephalosporins MOA

A

Inhibits cell wall synthesis by binding to and inhibiting PBPs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Carbapenems MOA

A

Inhibits cell wall synthesis by binding to and inhibiting PBPs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Monobactams MOA

A

Inhibits cell wall synthesis by binding to and inhibitings PBPs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Fluoroquinolones MOA

A

Inhibits DNA synthesis by inhibiting bacterial topoisomerases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Macrolides MOA

A

Inhibits protein synthesis by binding to 50S ribosomal subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Ketolides MOA

A

Inhibits protein synthesis by binding to 50S ribosomal subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Aminoglycosides MOA

A

Inhibits protein synthesis by irreversibly binding to 30S ribosomal subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Vancomycin MOA

Dalbavacin MOA

A

Inhibits 2nd stage of cell wall synthesis by binding to D-Ala-D-Ala cell wall precursors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Quinupristin-dalfopristin MOA

A

Inhibits protein synthesis by binding to 50S ribosomal subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Linezolid MOA

Tedizolid MOA

A

Inhibits protein synthesis by binding to 50S ribosomal subunit near 30S interface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Daptomycin MOA

A

Causes membrane depolarization by inserting lipophilic tail in cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Telavancin MOA

Oritavacin MOA

A

Inhibits cell wall synthesis by binding to D-Ala-D-Ala cell wall precursors AND causes membrane depolarization by inserting lipophilic tail in cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Tetracyclines MOA

A

Inhibits protein synthesis by binding to 30S ribosomal subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Glycylcyclines MOA

A

Inhibits protein synthesis by binding to 30S ribosomal subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Trimethoprim-sulfamethoxazole MOA

A

Sequential inhibition of microbial folic acid synthesis pathway by inhibiting bacterial dihydropteroate synthetase and dihydrofolate reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Polymyxins MOA

A

Binds to phospholipids in cell membrane causing displacement of Ca and Mg which leads to changes in cell wall permeability and leakage of cellular contents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Clindamycin MOA

A

Inhibits protein synthesis by binding to 50S ribosomal subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Metronidazole MOA

A

Prodrug activated by ferrdoxins whose activated metabolites damage bacterial DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Penicillins MOR

A
  1. Beta lactamase production
  2. Altered PBPs
  3. Decreased penetration through outer cell membrane
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Cephalosporins MOR

A
  1. Beta lactamase production
  2. Altered PBPs
  3. Decreased penetration through outer cell membrane
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Carbapenems MOR

A
  1. Beta lactamase production
  2. Altered PBPs
  3. Decreased penetration through outer cell membrane
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Monobactams MOR

A
  1. Beta lactamase production

2. Decreased penetration through outer cell membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Fluoroquinolones MOR

A
  1. Mutation in genes that code for DNA gyrase or topoisomerase IV (change in binding site)
  2. Efflux
  3. Decreased penetration through outer cell membrane
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Macrolides MOR

A
  1. Efflux

2. Change in ribosomal binding site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Ketolides MOR

A
  1. Change in ribosomal binding site
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Aminoglycosides MOR

A
  1. Altered aminoglycoside uptake
  2. Synthesis of aminoglycoside modifying enzymes
  3. Alteration in ribosomal binding sites (strepto)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Vancomycin MOR

Dalbavancin MOR

A
  1. Modification of the D-alanyl-D-alanine vancomycin binding site
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Quinupristin-dalfopristin MOR

A
  1. Alteration in ribosomal binding site
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Linezolid MOR

Tedizolid MOR

A
  1. Alteration in ribosomal binding site (rare)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Daptomycin MOR

A
  1. Altered cell membrane binding through loss of membrane protein
32
Q

Telavancin MOR

Oritavancin MOR

A
  1. Modification of the D-alanyl-D-alanine site
33
Q

Tetracyclines MOR

A
  1. Tetracycline-specific efflux pumps
  2. Ribosomal protection proteins
  3. Enzymatic inactivation
34
Q

Glycylcyclines

A
  1. Multidrug efflux pump
35
Q

Trimethoprim-sulfamethoxazole MOR

A
  1. Mutation in dihydrofolate reductase or dihydropteroate synthase
36
Q

Polymyxins MOR

A
  1. Alteration in outer cell membrane (reduction in calcium, magnesium, lipopolysaccharide content and/or outer membrane proteins)
37
Q

Clindamycin MOR

A
  1. Alteration in ribosomal binding site
38
Q

Metronidazole MOR

A
  1. Altered growth requirements

2. Reduced transcription of ferredoxin gene

39
Q

Pencillins cidal or static?

A

bactericidal

40
Q

Cephalosporins cidal or static

A

bactericidal

41
Q

Carbapenems cidal or static?

A

bactericidal

42
Q

Monobactams cidal or static?

A

bactericidal

43
Q

Fluoroquinolones cidal or static?

A

bactericidal

44
Q

Macrolides cidal or static?

A

bacteriostatic

45
Q

Ketolides cidal or static?

A

bacteriostatic

46
Q

Aminoglycosides cidal or static?

A

bactericidal

47
Q

Vancomycin cidal or static?

Dalbavancin cidal or static?

A

bactericidal

48
Q

Quinupristin-dalfopristin cidal or static?

A

bacteriostatic

49
Q

Linezolid cidal or static?

Tedizolid cidal or static?

A

bacteriostatic

50
Q

Daptomycin cidal or static?

A

bactericidal

51
Q

Telavancin cidal or static?

Oritavancin cidal or static?

A

bactericidal

52
Q

Tetracyclines cidal or static?

A

bacteriostatic

53
Q

Glycylcyclines cidal or static?

A

bacteriostatic

54
Q

Trimethoprim-sulfamethoxazole cidal or static?

A

bactericidal

55
Q

Polymyxins cidal or static?

A

bactericidal

56
Q

Clindamycin cidal or static?

A

bacteriostatic

57
Q

Metronidazole cidal or static?

A

bactericidal

58
Q

Penicillins time or concentration dependent

59
Q

Cephalosporins time or concentration dependent

60
Q

Carbapenems time or concentration dependent

61
Q

Monobactams time or concentration dependent

62
Q

Fluoroquinolones time or concentration dependent

A

Concentration

63
Q

Macrolides time or concentration dependent

A

Time (azithromycin may be concentration dependent vs some organisms)

64
Q

Ketolides time or concentration dependent

A

Concentration

65
Q

Aminoglycosides time or concentration dependent

A

Concentration

66
Q

Vancomycin time or concentration dependent

Dalbavancin time or concentration dependent

67
Q

Quinupristin-dalfopristin time or concentration dependent

68
Q

Linezolid time or concentration dependent

Tedizolid time or concentration dependent

A

Time for Linezolid

Concentration for Tedizolid

69
Q

Daptomycin time or concentration dependent

A

Concentration

70
Q

Telavancin time or concentration dependent

Oritavancin time or concentration dependent

A

Concentration

71
Q

Tetracyclines time or concentration dependent

72
Q

Glycylcyclines time or concentration dependent

73
Q

Trimethoprim-sulfamethoxazole time or concentration dependent

74
Q

Polymyxins time or concentration dependent

A

Concentration

75
Q

Clindamycin time or concentration dependent

76
Q

Metronidazole time or concentration dependent

A

Concentration

Antimicrobial Therapy (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions