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TOX 4000 Medical Toxicology > Principles > Flashcards

Principles Flashcards

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USMLE® Step 1 flashcards
1
Q

7 factors of causation vs correlation

A
  1. strength of association
  2. consistency of findings
  3. biological gradient (dose-response)
  4. temporal sequence (cause before effect)
  5. biological and theoretical plausibility (mechanism of action)
  6. coherence with established knowledge (no competing hypothesis)
  7. specificity of association (cause is tightly linked with outcome)
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2
Q

what is the ultimate toxicological dose-response

A

LD50

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3
Q

define therapeutic index

A

window between an effective dose and a toxic dose

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4
Q

equation for therapeutic index

A

TO= TD50/ED50

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5
Q

is larger or smaller TI associated with greater safety

A

wider TI= greater safety

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TOX 4000 Medical Toxicology (6 decks)

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