Priming and calculating RHct Flashcards
3 priming solutions ?
Lactated Ringers Normosol
Plasmlyte
Amount of Adult priming LR solution?
1600 ml
Amount of Adult priming Heparin drug?
5000 u
Amount of Adult priming Manitol medication?
12.5 g
Amount of Adult priming NaHCO3 solution?
50 meq
Amount of Adult priming Amicar drug?
5 g
Amount of Adult priming Kefsol solution?
1 g
Amount of Adult priming Albumin solution?
12.5 g (perfusionist dependant)
Pediatric priming Heparin dose?
3000 - 5000 u
Pediatric priming Albumin dose?
50 ml 25%
Pediatric priming Manitol dose?
200 mg/kg
Pediatric priming NaHCO3 dose?
3 meq / 100 ml prime
Pediatric priming Amicar dose?
150 mg / kg
Pediatric priming Solumedrol dose?
30 mg/kg (less than 6 months old)
Pediatric priming Kefsol dose?
30 mg / kg
Where is heparin harvested from ?
Pig liver, lung, and intestines. Its is also a natural anticoagulant in mast cells.
Action of Heparin?
Heparin binds to antithrombin III (AT III) and super-activates its function.
- Low doses= prevents conversion of prothrombin to thrombin by deactivation of factor Xa.
- High doses = Thrombin is neutralized preventing the conversion of fibrinogen to fibrin.
Heparin
Circuit Dose?
Patient dose ?
Circuit = 5000 u Patient = 300 mg/kg
Manitol pharmacological classification ?
Osmotic diuretic
Action of Manitol an organic sugar alcohol ?
Increases Osmotic pressure of the glomerular filtrate, thereby inhibiting reabsorption of water and electrolytes and therefore causing its excretion.
Ischemia increases “oxidative stress” and forms many oxygen radicals. How do these radicals effect the human body and what medication is indicated to treat this condition?
Free radical have an odd number of unpaired electrons. Each time a free radical comes into contact with tissue cells, the free radical steals one of its electrons creating free radical damage to the tissue. This condition can be resolved with administration of mannitol which would provide electrons to these free radicals.
Sodium Bicarbonate
NaHCO3
Disassociates into Na+ and bicarbonate ions HCO3. Bicarbonate acts as a buffer to neutralize acidosis.
Amicar
Inhibition of Plasmin Activators. Helpful after bypass with stabilization of clot formation. Amicar should be administered before the case.
Albumin
-Human Blood protein
-5% = plasma oncotic force
-Increases oncotic properties of prime
-Reduces surface adhesion, helps to de-air circuit.
“we know we do not use enough”
