Primary & Secondary headache syndrome Flashcards
How does subarachnoid hemorrhage present
Instant peak in pain
What are some red flags for headache?
- New onset >55 y/o
- Known/previous malignancy
- Immunosuppressed
- Early morning headache
- Exacerbated by valsava
How often do migraine attacks generally occur?
once a month
Is a migraine with aura effecting both or one eye?
Both
How likely is it that a migraine has ‘aura’ (visual involvement)?
20%
What is the criteria for a migraine with aura?
- At least 5 attacks
- Last 4-72hrs
- 2 of: Moderate/severe, unilateral, throbbing pain, worse movement
- 1of: autonomic features, photophobia/phonophobia
What is the biggest trigger for migraines?
Stress
How does stress cause migraine?
- Stress triggers changes in the brain leading to serotonin release
- Blood vessels constrict and dilate
- Chemicals including substance P irritate nerves and blood vessels causing pain
Where is the migraine center?
Dorsal raphe nuclei & Locus coeruleus
How is migraine treated non-pharmacologically?
- setting goals
- avoid triggers
- headache diary
- Relaxation/stress management
How is migraine treated pharmacologically?
Acute
- NSAID (aspirin, naproxen, ibuprofen) +/- Anti-emetic
- Triptans (rizatriptan, fovatriptan)
Prophylaxis
- Amitriptyline (10-25mg normally)
- Propranolol (80-240mg)
- Topiramate (25-100mg)
When is prophylaxis considered for migraine?
> 3 attacks a month
OR
Very severe attack
How long does each method of prophylaxis need to be trialed for in migraine?
at least 3 months
What are some contraindications to propranolol use in migraine?
Asthma
PVD
Heart failure
What are adverse effects of amitriptyline?
- Dry mouth
- Postural hypotension
- Sedation
What are some adverse effects of topiramate?
- Weight loss
- Paresthesia
- Impaired concentration
- Enzyme inducer
What does CGRP do?
Triggers receptors which open up pain pathways to start migraine attacks