Primary Coagulation Factors

Question 1

Prekallikrein (PK)Name(s)PathwayCharacteristic

Answer 1

Name:Fletcher factorPathway:IntrinsicCharacteristic: Functions with HMWK and factor XII

Question 2

HMWKName(s)PathwayCharacteristic

Answer 2

Name:High Molecular Weight KilinogenPathway: IntrinsicCharacteristic:co factor in kallikrein & factor XII activation, necessary in factor XIIa activation of XI, precursor for bradykinin (potent dilator & inducer of smooth muscle contraction)

Question 3

IName(s)PathwayCharacteristic

Answer 3

Name:FibrinogenPathway: BOTHCharacteristic:synthesized in liver, also acute phase reactant

Question 4

IIName(s)PathwayCharacteristic

Answer 4

Name: ProthrombinPathway:BOTHCharacteristic: Vitamin K dependent

Question 5

IIIName(s)PathwayCharacteristic

Answer 5

Name: Tissue FactorPathway: ExtrinsicCharacteristic: Released after tissue injury

Question 6

IV Name(s)PathwayCharacteristic

Answer 6

Name: CalciumPathway:BOTHCharacteristic: Necessary for activation of factor IX, X, for conversion of prothrombin to thrombin by Xa and for polymerization of fibrin monomers

Question 7

VName(s)PathwayCharacteristic

Answer 7

Name: Proaccelerin, labile factor, accelerator globulinPathway: BOTHCharacteristic: Protein co-factor; also important co-factor in activated protein C’s ability to function as a physiologic anticoagulant

Question 8

VI (same as Va)Name(s)PathwayCharacteristic

Answer 8

Name:AccelerinPathway: BOTHCharacteristic: NOT USED

Question 9

VIIPathwayCharacteristic

Answer 9

Pathway: ExtrinsicCharacteristic: Vit K dependent

Question 10

VIIIName(s)PathwayCharacteristic

Answer 10

Name: Antihemophilic factor APathway: IntrinsicCharacteristic: Protein co-factor on X chromosome; synthesized in the liver, but also in endothelial cells in all tissue; common deficiency - Hemophilia B

Question 11

IXName(s)PathwayCharacteristic

Answer 11

Name: Christmas factor, antihemophilic factor BPathway: IntrinsicCharacteristic: Vit K dependent; deficiency - Hemophilia B

Question 12

XName(s)PathwayCharacteristic

Answer 12

Name: Stuart Prower FactorPathway: BOTHCharacteristic: Vit K dependent; key entry protein in the common pathway; rare congenital deficiencies, acquired deficiency associated with amyloidosis

Question 13

XIName(s)PathwayCharacteristic

Answer 13

Name: Plasma thromboplastin atecedent (PTA)Pathway: IntrinsicCharacteristic: synthesized in liver; third most common deficiency, but rare bleeding diathesis

Question 14

XIIName(s)PathwayCharacteristic

Answer 14

Name: Hageman FactorPathway: IntrinsicCharacteristic: Activated in vivo by cell components such as fatty acids, endotoxin, cerebrosides; associated with activation of complement and fibinolysis

Question 15

XIIIName(s)PathwayCharacteristic

Answer 15

Name: Protransglutaminase, fibrino ligasePathway: BOTHCharacteristic: stabilizes conversion of fibrin monomer to polymerized fibrin & a stable clot; synthesized in liver and is present in platelets; deficiencies associated with delayed wound healing & recurrent spontaneous abortion