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physiology and pharmacology of the cns > primary amine neurotransmitter > Flashcards

primary amine neurotransmitter Flashcards

1
Q

principles of neurotransmitter action?

A

synthesis, storage, release, receptors, removal, degradation, drugs and disease

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2
Q

dopamine is the precursor for?

A

noradrenaline

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3
Q

brain dopamine pathways?

A

nigrostriatal pathway, mesolimbic pathway, mesocortical pathway, and tuberoinfundibular pathway.

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4
Q

what does the nirostriatal pathway control?

A

movement

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5
Q

what does the mesolimbic pathway control?

A

increases responsiveness to external and internal stimuli

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6
Q

what does the mesocortical pathway control?

A

normal cognition, motivation and emotions

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7
Q

what does the tuberoinfundibular pathway control?

A

arcuate nucleus (hypothalamus) to median eminence, prolactin release from anterior pituitary

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8
Q

what metabolises dopamine?

A

MAO and COMT

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9
Q

how does cocaine affect dopamine transmission?

A

inhibits DAT so acts as a stimulant, addictive

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10
Q

how does amphetamine affect dopamine transmission?

A

increases DA release, inhibits uptake, acts as a stimulant and induces psychosis. addictive

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11
Q

how does L-DOPA affect dopamine transmission?

A

precursor for dopamine, increases DA formation. treats parkinson’s

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12
Q

how do MAOb and COMT inhibitors affect dopamine transmission?

A

reduce DA metabolism and L-DOPA metabolism. treats parkinson’s

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13
Q

how do dopamine agonists affect dopamine transmission?

A

activate DA receptors to treat parkinson’s

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14
Q

what are the two noradrenlaine pathways/nuclei?

A

locus coreuleus and caudal raphe nuclei

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15
Q

what metabolises noradrenaline?

A

COMT and MAOa

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16
Q

adrenergic receptors of noradrenaline?

A

alpha1, alpha2, beta1, beta2

17
Q

how do alpha2 noradrenaline receptors act presynaptically?

A

inhibit transmitter release, inhibit voltage dependent ca channels

18
Q

how do alpha1 noradrenaline receptors act postsynaptically?

A

activate PLC, increase IP3 and DAG, increase calcium

19
Q

how do alpha2 noradrenaline receptors act postsynaptically?

A

inhibit adenylate cyclase
activate K+ channels
increase k+ efflux
inhibit voltage dependent calcium channels

20
Q

how does amphetamine affect noradrenaline transmission?

A

displaces NA from vesicles, MAO inhibitor, increases NA release. acts as stimulant, induces psychosis, addictive

21
Q

how does cocaine affect noradrenaline transmission?

A

inhibits NET, acts as stimulant, addictive

22
Q

how do antidepressants affect noradrenaline transmission?

A

inhibit NET so useful in depression

23
Q

how does ephedrine affect noradrenaline transmission?

A

increases NA release, B agonist, CNS stimulant, used as nasal decongestant

24
Q

how do monoamine oxidase inhibitors affect noradrenaline transmission?

A

inhibits MAO so reduces NA metabolism, treats depression

25
Q

what metabolises 5-HT?

A

MAOa

26
Q

how does ecstasy affect 5-Ht transmission?

A

releases 5HT > DA, substance of abuse

27
Q

how do MAO inhibitors affect 5-HT transmission?

A

reduces metabolism, treats depression

28
Q

how does cocaine affect 5-HT transmission?

A

blocks SERT, substance of abuse

29
Q

how does fenfluramine affect 5-HT transmission?

A

increases 5-HT release, blocks SERT, treated obesity

30
Q

how does prozac affect 5-HT transmission?

A

SSRIs block SERT

physiology and pharmacology of the cns (12 decks)

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