Preventive cardiology

Question 1

Each of the following statements regarding the effects of HMG-CoA reductase inhibitors is true EXCEPT:

a. The rate of cholesterol formation is decreased
b. Expression of hepatic LDL receptors is increased
c. Hepatic production of VLDL is decreased
d. Reversible hepatotoxicity develops in 10% of patients
e. Concurrent administration of erythromycin increases the risk of myositis

Answer 1

d. Reversible hepatotoxicity develops in 10% of patients

Question 2

True statements regarding genetic lipoprotein disorders include all of the following EXCEPT:

a. Patients with familial cambined hyperlipidemia are at inceased risk of CAD
b. Patients with familial hypertriglyceridemia typically develop xanthomas or xanthelasmas
c. Femilial hypercholesterolemia results from mutations in the LDL receptor gene
d. Dysbetalipoproteinemia develops in patients who are homozygous for the apo E2 allele
e. Familial defective apo B100 is often clinically indistinguishable from familial hypercholesterolemia

Answer 2

b. Patients with familial hypertriglyceridemia typically develop xanthomas or xanthelasmas