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Question 1

metastable polymorphic forms have

Answer 1

higher solubility and higher dissolution than the stable polymorphic form

Question 2

the crystal habit of a material influences the

Answer 2

dissolution rate,
the flow properties
external shape of the crystal

Question 3

micronised particles normally size no larger than

Answer 3

10 micro meters

Question 4

feret’s diameter is measured using the

Answer 4

light microscopy

Question 5

what property is needed for accurate measurement particle size analysis using dynamic light scattering

Answer 5

viscosity

Question 6

size reduction is

Answer 6

carried out by crack propogation and is more difficult for harder materials

Question 7

which property would result in segregation

Answer 7

markedly different particle size ranges

Question 8

powder flow is related to density and shape

Answer 8

spherical better flow and more dense better flow

Question 9

what can improve powder flow

Answer 9

use glidants
dry excipients
produce excipients by spray drying
alter the particle size distribution

( reducing particle size dosent )

Question 10

what would inc the dissolution rate of a poorly soluble drug formulated as an immediate release tablet

Answer 10

• change from stable to metastable polymorph of drug

- use a hydrophilic diluent