Pretest Missed Questions Flashcards
Central achromatopsia
`The complete inability to perceive color
Simultanagnosia
inability to integrate a visual scene to perceive as whole
Gerstmann syndrome
agraphia, calculation difficulties (acalculia), right-left disorientation, and finger agnosia. Likely due to lesions of parietal lobe of the dominant hemisphere (i.e. usually left parietal)
Apperceptive visual agnosia
inability to identify and draw items using visual cues
Color anomia
inability to name a color despite being able to point to it
Oculomotor apraxia
inability to direct gaze rapidly
prosopagnosia
inability to recognize faces in the presence of preserved recognition of other objects. Likely a disconnect between the left inferior temporal cortices and the visual association area in the left parietal lobe
Color agnosia
inability to recognize a color despite being able to match it
Balint syndrome
optic ataxia (inability to direct optically guided movements), oculomotor apraxia, and simultanagnosia - seen with bilateral parietal/occipital lobe lesions
Anton syndrome
failure to acknowledge blindness - associated with bilateral occipital lobe lesions
Associative visual agnosia
inability to name or use objects despite the ability to draw them - seen with bilateral medial occipito-temporal lesions
Target of sumatriptan
Serotonin 5-HT1D subtype
Atypical antipsychotics target receptor
Serotonin 5-HT6 (6 is sick) and Dopamine D4 subtypes
Receptor involved in regulating circadian rhythms
Serotonin 5-HT7, remember 7 hour time different to London = jet lag/circadian upset
Antihypertensive receptor target
Adrenergic a-1A,B,D
Anxiolytic receptor target
Serotonin 5-HT1A, “A” is for anxiety
Bronchial muscle contraction (or relaxation ala inhalers)
Adrenergic B2 - beta blockers can cause broncho constriction!!
Antiparkinsons Anticholinergic drug target
Cholinergic M4
Typical antipsychotic target
Dopamine D2 subtype (typically came first, hence D2, atypical came later, hence D4)
Diphenhydramine receptor target
H1 - old generation antihistamines came first “H1”
Grand mal Seizure EEG pattern
interictal epileptiform discharges
Hepatic encephalopathy EEG pattern
triphasic waves
General toxic encephalopathy (eg electrolyte imbalance) EEG pattern
Diffuse slowing of background rhythms
Stroke EEG Pattern
Periodic lateralizing epileptiform discharges
Creutzfeldt-Jakob Disease EEG
generalized periodic sharp waves
Opioid intoxication EEG
Decreased Alpha activity, increased theta and delta waves
Marijuana use EEG
Increased alpha activity in frontal lobes, overall slowed alpha activity
Caffeine withdrawal EEG
Increased amplitude/voltage of theta activity
Nicotine withdrawal EEG
Decreased alpha wave activity
Barbiturate withdrawal
Generalized paroxysmal activity and spike discharges
Where do most partial complex seizures originate?
Temporal lobes, may have olfactory hallucinations
What neurotransmitter is most likely involved in OCD?
Serotonin, implicated by patients responsiveness to SSRIs and TCAs.
What neurotransmitter is most likely involved in anxiety disorders?
Norepinephrine
Which neurotransmitter is most likely involved in cognitive and memory disorders?
Acetylcholine
Which neuropeptide affects the appetite?
Neuropeptide Y
What behavior results from lesions to the right prefrontal cortex?
Laughter, euphoria, tendency to joke and make puns. The resulting imbalance between right and left leads to the mood-elevating behavior produced by the left prefrontal cortex, and a lesion there would have the opposite effect
What is the effect of protein phosphatase-1?
Causes forgetting. Dephosphorylates cAMP response elements and decreases gene expression, PP1 effectively “cleans out” unused memories.