Pretest Missed Questions Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Central achromatopsia

A

`The complete inability to perceive color

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Simultanagnosia

A

inability to integrate a visual scene to perceive as whole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Gerstmann syndrome

A

agraphia, calculation difficulties (acalculia), right-left disorientation, and finger agnosia. Likely due to lesions of parietal lobe of the dominant hemisphere (i.e. usually left parietal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Apperceptive visual agnosia

A

inability to identify and draw items using visual cues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Color anomia

A

inability to name a color despite being able to point to it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Oculomotor apraxia

A

inability to direct gaze rapidly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

prosopagnosia

A

inability to recognize faces in the presence of preserved recognition of other objects. Likely a disconnect between the left inferior temporal cortices and the visual association area in the left parietal lobe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Color agnosia

A

inability to recognize a color despite being able to match it

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Balint syndrome

A

optic ataxia (inability to direct optically guided movements), oculomotor apraxia, and simultanagnosia - seen with bilateral parietal/occipital lobe lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Anton syndrome

A

failure to acknowledge blindness - associated with bilateral occipital lobe lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Associative visual agnosia

A

inability to name or use objects despite the ability to draw them - seen with bilateral medial occipito-temporal lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Target of sumatriptan

A

Serotonin 5-HT1D subtype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Atypical antipsychotics target receptor

A

Serotonin 5-HT6 (6 is sick) and Dopamine D4 subtypes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Receptor involved in regulating circadian rhythms

A

Serotonin 5-HT7, remember 7 hour time different to London = jet lag/circadian upset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Antihypertensive receptor target

A

Adrenergic a-1A,B,D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Anxiolytic receptor target

A

Serotonin 5-HT1A, “A” is for anxiety

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Bronchial muscle contraction (or relaxation ala inhalers)

A

Adrenergic B2 - beta blockers can cause broncho constriction!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Antiparkinsons Anticholinergic drug target

A

Cholinergic M4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Typical antipsychotic target

A

Dopamine D2 subtype (typically came first, hence D2, atypical came later, hence D4)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Diphenhydramine receptor target

A

H1 - old generation antihistamines came first “H1”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Grand mal Seizure EEG pattern

A

interictal epileptiform discharges

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Hepatic encephalopathy EEG pattern

A

triphasic waves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

General toxic encephalopathy (eg electrolyte imbalance) EEG pattern

A

Diffuse slowing of background rhythms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Stroke EEG Pattern

A

Periodic lateralizing epileptiform discharges

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Creutzfeldt-Jakob Disease EEG

A

generalized periodic sharp waves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Opioid intoxication EEG

A

Decreased Alpha activity, increased theta and delta waves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Marijuana use EEG

A

Increased alpha activity in frontal lobes, overall slowed alpha activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Caffeine withdrawal EEG

A

Increased amplitude/voltage of theta activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Nicotine withdrawal EEG

A

Decreased alpha wave activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Barbiturate withdrawal

A

Generalized paroxysmal activity and spike discharges

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Where do most partial complex seizures originate?

A

Temporal lobes, may have olfactory hallucinations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What neurotransmitter is most likely involved in OCD?

A

Serotonin, implicated by patients responsiveness to SSRIs and TCAs.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What neurotransmitter is most likely involved in anxiety disorders?

A

Norepinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Which neurotransmitter is most likely involved in cognitive and memory disorders?

A

Acetylcholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Which neuropeptide affects the appetite?

A

Neuropeptide Y

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What behavior results from lesions to the right prefrontal cortex?

A

Laughter, euphoria, tendency to joke and make puns. The resulting imbalance between right and left leads to the mood-elevating behavior produced by the left prefrontal cortex, and a lesion there would have the opposite effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What is the effect of protein phosphatase-1?

A

Causes forgetting. Dephosphorylates cAMP response elements and decreases gene expression, PP1 effectively “cleans out” unused memories.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

If a patient presents with recent onset anti-social PD or intermittent explosive disorder, which region of the brain may be damaged?

A

Orbitofrontal area. Dysfunction here results in disinhibition, irritability, lability, euphoria, lack of remorse, insight and judgement are impaired

39
Q

Patients who display recent loss of planning, motivation, goal directness, focus, or sustained effort, and appear inattentive may have a lesion where?

A

Dorsolateral area. Patients may also echo questions and react only to details of environmental stimuli.

40
Q

Chronic infections/neurosyphilis appearance on MRI

A

Enhanced meninges at base of brain (also seen with cryptococcosis, tuberculosis, lyme disease)

41
Q

Dementia and gait disorder in a 40 year old female, What MRI findings?

A

Most likely normal pressure hydrocephalus - Dilation of ventricles on MRI

42
Q

MRI appearance of multiple sclerosis?

A

Periventricular patches of increased signal intensity.

43
Q

MRI appearance of vascular dementia?

A

Patches of increased signal throughout the white matter, not just in periventricular locations

44
Q

Signs of infants exposed to cannabis in-utero

A

decreased visual responsiveness, tremor, increased startle reflex, disrupted sleep patterns

45
Q

Reactive attachement disorder types and behaviors

A

Inhibited type: persistent failure to initiate or respond to most social interactions in an appropriate way.
Disinhibited type: Indiscriminate sociability, ie excessive familiarity with strangers

46
Q

Reactive attachment disorder behaviors in children

A

Disregard of child by parents results in the child failing to develop secure and stable bonds with parents and difficulties relating to others. Children may be fearful, inhibited, withdrawn, and apathetic, or may be aggressive, disruptive, disorganized, with low frustration tolerance and poor affect modulation.

47
Q

Associated symptoms of major depression in children

A

Children’s symptoms may present differently than those of depressed adults. Sad affect may be replaced with aggression and irritability, prominent manifestations may be poor school functioning and refusal to attend school. Psychotic symptoms are present in 1/3 of childhood major depression.

48
Q

Psychiatric condition associated with cushing’s syndrome?

A

Depressive disorder - Substance/medication-induced

A result of exogenous steroid use (i.e. chronic asthma patients)

49
Q

First line treatment for new-onset psychosis/hallucinations in a delirious patient?

A

Haloperidol.
Delirium is treated by treating the underlying cause, but psychotic symptoms should be treated directly. Haloperidol may be administered IM.

50
Q

Panic disorder diagnosis

A

At least FOUR of the following: Shortness of breath, tachypnea, tachycardia, tremor, dizziness, hot or cold sensations, chest discomfort, depersonalization or derealization.

51
Q

Temporal lobe epilepsy symptoms

A

Hypo sexuality, emotional intensity, a perseverative approach to interactions (“viscosity”). Usually without grand map-like convulsions

52
Q

Pick disease symptoms

A

Insidious onset and gradual progression, early decline in social interpersonal conduct, emotional blunting and apathy without insight, marked decline in hygiene and significant distractibility.
Pick bodies are irregularly shaped, silver staining cytoplasmic inclusion bodies that displace the nucleus to the periphery.

53
Q

HIV dementia symptoms

A

impaired attention and concentration, psychomotor slowing, forgetfulness, slow reaction time, mood changes (depression). Brain atrophy.
The most frequent neurological complication of HIV, caused by the direct action of the virus on the brain.

54
Q

Normal pressure hydrocephalus symptoms

A

Wet, Wobbly, Wacky - Urinary incontinence, gait abnormality, dementia. Dementia features include: impaired attention, visuospatial deficits, poor judgement, apathy, inertia, lack of concern.

55
Q

Arsenic poisoning s/sx

A

bloody diarrhea (inflammation and necrosis of the intestinal mucosa, fluid loss, hypotension, nausea, vomiting, diarrhea, abdominal pain, delirium, coma, and seizures. Garlicky breath odor may be detected.

56
Q

Korsakoff syndrome memory deficits

A

Both anterograde and retrograde amnesia. Patients are unable to form new memories or recall recent events. Distant memory is typically preserved.

57
Q

S/sx of pancreatic cancer

A

Weight loss, depressed mood, apathy, anhedonia, decreased energy, and lethargy. Amylase may be elevated.

58
Q

Donepezil, rivastigmine, galantamine, tacrine drug class and uses

A

Cholinesterase inhibitors. May treat mild to moderate symptoms of Alzheimers. Donepazil is first line due to side effects of other drugs.

59
Q

Delirium tremens vs post-surgical delirium

A

DT presents with hypertension, tachycardia, and elevated temperature. “Normal” delirium does not.

60
Q

Serum test for grand mal seizure?

A

Prolactin. Serum prolactin level rise for 20 minutes following grand mal seizures. There is no change in prolactin levels following non-epileptic seizures, thus this test may help narrow the differential.

61
Q

Psychiatric side effects of corticosteroids

A

Mood disorders. Commonly mania or hypomania, may progress to depression with chronic steroid use. Steroid withdrawal may also precipitate mania or depression.

62
Q

3 drug treatments for neuroleptic malignant syndrome

A

Dantrolene, bromocriptine, amantidine

63
Q

Generalized anxiety disorder symptoms and treatment

A

Excessive worry/anxiety for more than 6 months with at least 3 of the following: restlessness/feeling on edge, fatigue, difficulty concentrating, irritability, muscle tension, sleep disturbance.

SSRI, SNRI

64
Q

Side effects of olanzapine

A
Weight gain is most common
Less common: Metabolic syndrome
Hyperglycemia
Dyslipidemia
New-onset Diabetes Mellitus
65
Q

Side effects of clozapine

A

Agranulocytosis
Seizures
Myocarditis
Metabolic syndrome

66
Q

Adjustment disorder definition and treatment

A

Emotional or behavioral symptoms that develop within 3 months following an identifiable stressor (end of relationship). Typically do not last more than 6 months.
Treatment is psychotherapy.

67
Q

Factors that indicate a poor prognosis in schizophrenia

A

early or insidious onset, lack of obvious precipitating causes, poor premorbid functioning, neurologic signs/symptoms, social isolation, family history of schizophrenia, presence of negative symptoms

68
Q

Perphenazine drug class

A

Typical antipsychotic

69
Q

What type of hallucination (visual, olfactory, audio, etc) are most commonly purely psychogenic and not indicative of medical disease?

A

Auditory hallucinations are most often purely psychogenic

70
Q

Effect of hostile or controlling family environment on psychotic patients

A

Increased relapse rates

71
Q

What complication is seen in 90% of all terminally ill patients?

A

Delirium, often results from condition or medications to treat it. It may be treated by resolving the underlying condition or with antipsychotics. Other conditions like depression, anxiety, and delusions occur but not at the same rate.

72
Q

What are two short acting benzos?

A

lorazepam alprazolam

73
Q

Pharmacotherapy for panic attacks?

A

SSRI plus short acting benzodiazepine (alprazolam/lorazepam). The benzo should be used for acute attacks only and then discontinued once the SSRI is tapered to an effective level (~4 weeks)

74
Q

What REM patterns and movements during sleep are associated with narcolepsy?

A

Sleep-onset REM period, or very rapid progression to REM sleep. Nocturnal myoclonus or sleep apnea may also be seen in a patient.

75
Q

What drug interactions must be considered in HIV patients?

A

CYP450 interactions. Antiretroviral drugs are metabolized by CYP450 and compete with many psychotropic drugs, increasing their levels. Bupropion, meperidine, various benzos, and SSRIs are all affected and will have higher than intended concentrations in HIV patients.

76
Q

What is the management for clozapine-induced agranulocytosis?

A

Baseline CBC and weekly CBC for 6 months.
Mild WBC 3000-3500 = 2/week CBC w differentials but continue drug therapy
Moderate WBC 2000-3000 = Stop Clozapine, Daily CBC, restart clozapine after counts normalize
Severe WBC less than 2000 = Stop clozapine, place patient in protective isolation, bone marrow sample, never restart clozapine

77
Q

Treatment for lithium overdose?

A

Moderate overdose, below 2.0 = supportive, IV saline, monitor urine output and frequent Li levels
Severe overdose, 2.1 and above = emergency dialysis

78
Q

Contraindications for ramelteon?

A

severe hepatic impairment, severe sleep apnea, severe COPD

79
Q

Side effects of carbamazepine?

A

aplastic anemia, agranulocytosis, thrombocytopenia, leukopenia. A benign rash may develop, and carbamazepine must be discontinued because of the potential for a severe rash to follow this.

80
Q

Flushed appearance, dry skin and palms, and tachycardia are symptoms of what?

A

Anticholinergic syndrome.

81
Q

Treatment for akathesia

A

Beta blockers (propranolol) are most effective. Benzos and anticholinergics are helpful but less effective

82
Q

What anesthetic agent is used in ECT?

A

Barbiturates (methohexital)

83
Q

What is the half-life of lithium and how long does it take to achieve therapeutic concentrations?

A

Half life is 20 hours

4-7 days to effective concentrations

84
Q

What is the best antipsychotic for use in a patient with parkinson’s disease?

A

Quetiapine. Has the least EPS and is anticholinergic so it may improve parkinson’s symptoms

85
Q

Treatment for clozapine-induced seizures?

A

Stop clozapine and administer valproic acid. Clozapine is then restarted at 50% of its previous level and titrated up.

86
Q

Antipsychotics that can be used in patients with orthostatic hypertension

A

Haloperidol, fluphenazine. High potency typical antipsychotics

87
Q

Dizziness, nausea, vomiting, lethargy, flu-like symptoms, and sensory or sleep disturbances are symptomatic of what?

A

Abrupt SSRI discontinuation.

88
Q

What are tyramine containing foods that are most likely to cause hypertensive crisis?

A

aged cheese, salami, pepperoni, sausage, over-ripe fruit, liquors, red wine, pickled fish, sauerkraut, and brewer’s yeast (but not beer itself, which has lower quantities of tyramine and may be consumed in small quantities.

89
Q

What drugs may be used to treat narcolepsy by delaying REM sleep?

A

Most antidepressants: SSRIs, TCAs, MAOIs

90
Q

What two conditions is imipramine used for that are not mood disorders?

A

Bed wetting

ADHD

91
Q

What is the most important adverse side effect of sildenafil (or likely other impotence drugs)?

A

Myocardial infarction, due to increased oxygen demand and stress placed on the heart during sex.

92
Q

What cardiac effects do TCAs have?

A

Slowing of cardiac conduction. May be beneficial at lower doses, but may also cause fatal heart block and prolonged QRS complex at high doses.

93
Q

Treatment for lithium-induced tremor?

A

Mild tremor: dose reduction, caffeine elimination, slow release lithium preparations, beta-blockers.
Severe tremor: sign of toxicity

94
Q

What is rabbit syndrome?

A

Very similar to tardive dyskinesia, but chewing movements are very rapid and the tongue and other body parts are not involved. Uncommon.