Preterm infant Flashcards
Definitions:
- Neonate is first how many days after birth?
- Gestational age is the time elapsed between the first day of the last normal what and the day of what? (MP, B)
- Chronological age is the time elapsed after what? (B)
- Post-Conceptual Age is the sum what of what 2 ages?
- 28 days
- menstrual period, birth
- birth
- gestational and chronologic
Definitions:
1. Preterm is birth before how many gestational weeks?
2. “Preemies” should have what 2 ages
to help identify where infant is their maturation of their physiologic processes?
- 37
2. gestational and chronologic age
Classified Weight:
- Low Birth Weight is < how many grams?
- Very Low Birth Weight is < how many grams?
- Extremely Low Birth Weight is < how many grams?
- 2500 grams
- 1500 grams
- 1000 grams
Classified age:
- Mod to Late prematurity is what week range?
- Very Premature is what week range?
- Extremely Premature is what week range?
- 32 to < 37
- 28 to < 32
- < 28
Small airways:
- Increase in resistance to what? (A)
- Resistance to airflow is inversely proportional to the radius of the lumen to the what power for laminar flow to the what power for turbulent flow?
- Turbulent flow is from what to what bronchial division?
- Laminar flow is beyond what bronchial division?
- does the ETT increase or decrease resistance and work of breathing?
- does adding anesthesia increase or decrease WOB?
- anesthesia causes a loss in muscle toning creating a partial what? (O)
- airway
- 4th, 5th
- mouth to 4th bronchial division
- 5th
- increase
- increase
- obstruction
Subglottic Stenosis
- is the narrowing of airway below what? (VC)
- what are 3 causes? (PI, C, TFE)
- does this necessitate a smaller than normal ETT?
- how much smaller?
- vocal cords
- prolonged intubation, congenital, trauma from ETT
- yes
- 0.5
Tracheal Stenosis
- is the narrowing of trachea below what and above what? (VC, C)
- what are 4 causes? (PI, PT, C, T)
- may not need a smaller ETT because the stenosis is what to ETT? (D)
- will there still be an increased resistance and WOB?
- may there be trouble ventilating because of increased resistance?
- vocal cords, carina
- prolonged intubation, prolonged tracheostomy, congenital, trauma
- distal
- yes
- yes
Tracheobronchomalacia
- does the airway collapse during inhalation or exhalation?
- what are 2 things to stent open the airway? (C, P)
- is a higher PEEP usually is needed?
- Mechanical ventilation is better than spontaneous ventilation because it will help do what to the airways and decrease what 2 things? (SO; F, W)
- Should you use larger or smaller I:E ratios to prevent air trapping and hyperinflation?
- exhalation
- CPAP, PEEP
- yes
- stent open; fatigue, work of breathing
- smaller
Respiratory: High Metabolic Rate
- neonates have an increased in what 2 things? (AV, OC)
- what is average neonate alveolar ventilation ml/kg/min?
- what is average adult alveolar ventilation ml/kg/min?
- what is average neonate oxygen consumption ml/kg/min?
- what is average adult oxygen consumption ml/kg/min?
- what can be difficult to maintain normal d/t a neonates alveolar ventilation? (E)
- is the premature oxygen consumption higher or lower than neonates?
- do neonates have a rapid decrease in PaO2?
- alveolar ventilation, oxygen consumption
- 130 ml/kg/min
- 60 ml/kg/min
- 5-8 ml/kg/min
- 2-3 ml/kg/min
- ETCO2
- higher
- yes
Lungs: Pulmonary Gas Exchange
- lungs are immature in what 2 things? (S, F)
- Alveoli are what 3 things? (T, FF, SD)
- do alveoli require greater or lesser pressure to expand?
- production of what by type 2 alveolar pneumocytes is inadequate? (S)
- what gestational week range does surfactant production start?
- surfactant remains inadequate until what week?
- preemies are born with what syndrome? (RDS)
- structure, function
- thick, fluid filled, surfactant deficient
- greater
- surfactant
- 23-24 weeks
- 36 weeks
- respiratory distress syndrome
Immature lungs lead to Respiratory Distress Syndrome (RDS)
- decreases in what 2 things (LV, C)?
- increase intrapulmonary shunting leads to what mismatch and increases the risk of what? (VP, H)
- what are 3 clinical signs? (G, NF, CR)
- anesthesia decrease lung volumes even more which leads to increase in what mismatch and an increase risk of what? (VP, H)
- lung volume, compliance
- VP, hypoxia
- grunting, nasal flaring, chest retractions
- VP, hypoxia
Pulmonary Gas Exchange and Atelectasis
- Large abdomen pushes diaphragm cephalad causes disruption in what and places the what capacity within the expiratory reserve volume? (GE, CC)
- Closing capacity is the volume in the lungs at which the smallest airways do what? (C)
- expiratory reserve volume is the amount of air exhaled during what type of exhale? (F)
- do alveoli close quicker in premature infants?
- what other 3 things can increase abd pressure resulting in the closing capacity to be within the ERV? (OM, SP, SR)
- gas exchange closing capacity
- collapse
- forced
- yes
- overzealous masking, surgical procedure, surgical retraction
- anatomic forces that disrupt gas exchange result in what 2 things? (A, IS)
- what are 4 strategies to help improve a disrupted gas exchange? (MV, P, ES, CSA)
- atelectasis, intrapulmonary shunting
2. mechanical ventilation, PEEP, empty stomach, change surgical position
Mechanical lung injury:
- this can be caused by increased what volumes and frequent collapsing and reopening of what? (EILV, A)
- are micropreemies more susceptible to mechanical lung injuries?
- not having enough what contributes this micropreemies being more susceptible to mechanical lung injuries? (S)
- to prevent lung injuries we use what range of tidal volumes (ml/kg), greater what, sufficient what and permissive what? (RR, P, H)
- what is the permissive range we allow?
- end-inspiratory lung volume, atelectasis
- yes
- surfactant
- 4-6 ml/kg, RR, PEEP, hypercapnia
- 45-55 mmHg
Bronchopulmonary Dysplasia (BPD)
- defined as the need for supplemental oxygen at what postnatal days?
- In BPD, high levels of what and what type of ventilation disrupts maturation of alveoli in preemies? (O, M)
- at what weeks gestation does alveolarization begin?
- are alveoli larger or smaller and more or fewer?
- do alveoli have an increased or decreased SA which increases or decreases O2 requirements?
- 28 days
- oxygen, mechanical
- 36 weeks
- larger, fewer
- decreased SA, increases
Bronchopulmonary Dysplasia (BPD)
- severity is based on what 2 things? (F, P)
- greater risk for perioperative what? (C)
- goal is SpO2 in what % range and PaO2 in what mmHg range?
- FiO2, PPV
- complications
- 90-94%, 50-55 mmHg
How do we prevent BPD?
- what is one thing we can give mom and baby? (AC)
- what is one type of therapy? (EST)
- early and aggressive use of what to prevent ETT?
- what 2 type of meds can we give? (D, B)
- antenatal corticosteroids
- exogenous surfactant therapy
- CPAP
- diuretics, bronchodilators
Hyperoxia
1. what 2 prematurity-related diseases are associated with hyperoxia? (R, B)
2. Oxygen toxicity from hyperoxia leads
to the formation of reactive oxygen what that impair intracellular macromolecules and lead to cell what? (I, D)
3. formation of oxygen free radicals promotes an extensive inflammatory response, leading to what damage and cell what? (T, D)
4. Oxygen-induced vascular endothelial growth factor (VEGF) signals disturbances associated with abnormal what, which it may be detected in what 2 diseases? (A; R, B)
5. oxygen supplementation strategy: recent evidence suggest a graded approach according to what age, meaning increasing O2 saturation targets with increasing what? (G, A)
- retinopathy of prematurity, bronchopulmonary dysplasia
- intermediaries, death
- tissue damage, cell death
- angiogenesis; retinopathy of prematurity, bronchopulmonary dysplasia
- gestational age, age
Respiratory control:
- premature infants have what type of ventilatory response to hypoxia? (B)
- Initially ventilation increases or decreases but after several minutes they do what and then what ensues? (D,A)
- Ventilatory response to what is decreased in micropreemie and what further blunts this response? (C,H)
- does anesthesia increase or decrease the ventilatory responses to hypoxia and hypercapnia?
- biphasic
- increases, decrease, apnea
- CO2, hypoxia
- decrease
Apnea of Prematurity
- occurs commonly in micropreemies and increases or decreases with post-conceptual age?
- is it centrally, obstructively or both?
- central apnea is caused by a decrease in output from where? (RC)
- this decreased output is exacerbated by what 3 things? (H, H, H)
- obstructive apnea occurs because of the incoordination of what muscle? (P)
- is this incoordination made better or worse by anesthesia?
- decreases
- both
- respiratory center
- hypothermia, hypoglycemia, hypocalcemia
- pharyngeal muscle
- worse
Postoperative Apnea
- the incidence of this depends on what 3 things? (PCA, A, ToS)
- which of these is the most significant risk factor?
- occurs in what % of micropreemies?
- increased risk what hct is < what %?
- is it more common after major procedures like laparotomies or peripheral surgical procedures like inguinal hernia repairs?
- usually how many hours after emergence and can be up to how many hours?
- defined as apnea greater than how many seconds or brief apnea with HR less than or equal to how many beats?
- post-conceptual age, anemia, type of surgery
- post-conceptual age
- 50%
- < 30%
- after major
- 1 hour, 48 hours
- > 15 sec, less than or equal to 80
Postoperative Apnea: intraop prevention strategies
- Avoid what type of drugs? (N)
- prevent what 2 things? (H, A)
- can it occur with regional anesthesia?
- what 2 methylxanthines can be give to help prevent? (C, T)
- why is caffeine preferred over theophylline?
- what is the mg/kg IV dose of caffeine?
- caffeine increases the respiratory centers sensitization to what? (H)
- narcotics
- hypovolemia, anemia
- yes
- caffeine, theophylline
- longer half-life
- 10 mg/kg
- hypercarbia
Fetal circulation:
- oxygenated blood from placenta travels via the what vein through the ductus venosus in the what to the what and into which atrium?
- Oxygenated blood from the IVC preferentially enters the which ventricle then goes to which artery?
- oxygen rich blood supplies the what prior to mixing with the oxygen poor blood coming through the what?
- Deoxygenated blood from the superior vena cava enters which ventricle and is pumped to the which artery?
- It then passes through the what to meet the oxygenated blood in the aorta? (DA)
- umbilical vein, liver, inferior vena cava, right atrium
- left ventricle, aorta
- brain, ductus arteriosus
- right ventricle pulmonary artery
- ductus arteriosus
Fetal Circulation to Neonatal Circulation: With first breath…
- lungs do what? (E)
- O2 tension increases or decreases?
- pulmonary vascular resistance increases or decreases?
- blood flows to where? (L)
- does SVR increase or decrease with cord clamping?
- expand
- increases
- decreases
- lungs
- increase