Presentations, Differentials, Work up Flashcards
Patient is a 52 y/o male w/ h/o 6 month cough w/hemoptysis, night sweats, low-grade temps, fatigue, sharp/pleuritic chest pain, and loss of 20 lbs unintentionally within the last 4 months.
Social Hx: significant for recent prison release, sexually active w/men w/o condom use
Differentials?
Tuberculosis
Pneumocystis jiroveci pneumonia
HIV
Patient is a 52 y/o male w/ h/o 6 month cough w/hemoptysis, night sweats, low-grade temps, fatigue, sharp/pleuritic chest pain, and loss of 20 lbs unintentionally within the last 4 months.
Social Hx: significant for recent prison release, sexually active w/men w/o condom use
Work/up?
CBC w/diff
CXR
sputum gram stain and culture
PPD or quantiferon gold
HIV RNA PCR
Patient is a 63 y/o M presenting to the clinic for back pain for the past three days. Associated with fever, chills, dysuria, polyuria, fatigue, and nausea.
PMH- recurrent UTIs
On PE, patient has suprapubic tenderness, fever, tachycardia, and right CVA tenderness
Possible diagnosis?
Pyelonephritis
Patient is a 63 y/o M presenting to the clinic for h/o 3 days of back pain. ROS: dysuria, poluria, fever PMH- Diabetes and recurrent UTIs
PE- significant for suprapubic tenderness
Possible diagnosis?
Cystitis
Patient is a 63 y/o M presenting to the clinic for h/o 3 days of back pain that radiates to his groin. ROS: polyuria, dysuria, nausea
PE- tachycardia, CVA tenderness on right side, suprapubic tenderness
Possible diagnosis?
nephrolithiasis
Patient has dysuria, polyuria, and suprapubic tenderness. Differentials?
UTI
Nephrolithiasis
Cystitis
Pyelonephritis
Patient has dysuria, polyuria, and suprapubic tenderness.
Work up?
CBC w/diff
U/A
Urine culture
Renal U/S
CT abd/pelvis without IV contrast
Patient is a 72 y/o F presenting to the clinic for bloody stool for one day.
Differentials?
Diverticulosis
Hemorrhoids
Colon Cancer
Upper GI bleed
Patient is a 72 y/o F w/ painless bloody stool for one day. ROS: +weakness, +dizziness
No significant FH of colon cancer
PE shows no adominal masses, no fever, NAD
Possible diagnosis?
Diverticulosis
Patient is a 72 y/o F w/painless bloody stool with no weight loss, no abdominal masses, and no fever. Patient is in NAD and the blood is present when she wipes.
Possible diagnosis?
Hemorrhoids
Patient is a 72 y/o F w/h/o blood in stools. She has never had a colonoscopy.
What diagnosis should you be concerned for?
Colon cancer
Patient is a 72 y/o F w/ painless bloody stool for one day. ROS: +weakness, +dizziness
No significant FH of colon cancer
PE shows no adominal masses, no fever, NAD
Work up?
Rectal exam (be sure to explain this to the patient in the counseling)
FOBT
CBC w/diff
PT/PTT/INR
CT scan of abd/pelvis
Colonoscopy
Patient is a 23 y/o f w/ irregular periods for the past ten years. Differential?
PCOS
Endometriosis
Pituitary tumor
Cushing Syndrome
Hyperthyroidism/Hypothyroidism
Anorexia Nervosa
Patient is a 23 y/o F w/ irregular menstrual cycles for the last 10 years. G0P0, FH of DM, ROS: +dysmenorrhea, acne, weight gain of 15lbs in last 5 yrs
PE: increased abdominal girth, hirsutism, facial acne
Possible diagnosis?
PCOS
Patient is a 23 y/o F w/irregular periods for 10 yrs. ROS: +15 lbs weight gain in last 5 yrs, constipation
PE: shows increased abdominal girth
Possible diagnosis?
hypothyroidism
Patient is a 23 y/o F w/irregular periods for 10 yrs. ROS: +15 lbs weight gain in last 5 yrs
PE: shows increased abdominal girth, facial acne, hirsuitism
Possible diagnosis?
Cushing syndrome
Pituitary Tumor
Patient is a 23 y/o F w/ irregular menstrual cycles for the last 10 years. G0P0, FH of DM, ROS: +dysmenorrhea, acne, weight gain of 15lbs in last 5 yrs
PE: increased abdominal girth, hirsutism, facial acne
Work up?
Pelvic Exam
FSH/LH
Serum hCG
Pelvic U/S
HbA1c, serum glucose
lipid panel (total cholesterol, HDL, LDL, TGs)
24-hr urinary cortisol excretion
Free testosterone level
Patient is a 16 y/o M w/sore throat for 1 day.
Possible differentials?
viral pharyngitis
bacterial pharyngitis
laryngitis
Mononucleosis
Patient is a 16 y/o M w/sore throat for one day. ROS: +odynophagia, fatigue, sick contacts, nasal discharge
PE: erythema on posterior pharynx, fever (no lymphadenopathy, no exudates)
Possible diagnosis?
Viral pharyngitis
Patient is a 16 y/o M w/sore throat for one day. ROS: +odynophagia, fatigue, sick contacts, headache
PE: erythema on posterior pharynx, fever
Possible diagnosis?
Bacterial pharyngitis
Patient is a 16 y/o M w/sore throat for one day. ROS: +odynophagia, fatigue, sick contacts
PE: erythema on posterior pharynx, fever
*Age of patient
Possible diagnosis?
infectious mononucleosis
Patient is a 16 y/o M w/sore throat for one day. ROS: +odynophagia, fatigue, sick contacts
PE: erythema on posterior pharynx, fever
Workup?
CBC w/diff
Peripheral blood smear
Rapid strep test
Throat culture
Monospot test
43 y/o M presents w/ hearing loss for the past 5 yrs.
Hearing loss is bilateral, progressively worsening, trouble hearing in noisy environments. Social hx: farmer exposed to loud noises, uses headphones often; normal Rinne’s and Weber’s tests
Possible diagnosis?
Presbycusis
43 y/o M presents w/ hearing loss for the past 5 yrs.
Hearing loss is bilateral, progressively worsening, trouble hearing in noisy environments. Social hx: farmer exposed to loud noises, uses headphones often, cleans ears with Q-tips daily; normal Rinne’s and Weber’s tests
Possible diagnosis?
Ruptured tympanic membrane
43 y/o M w/bilateral hearing loss w/hx of daily aspirin use
On PE, no erythema, polups, or exudates, minimal ear wax
Possible dx?
Hearing loss due to aspirin toxicity
43 y/o M presents w/ hearing loss for the past 5 yrs w/ h/o aspirin use daily.
Hearing loss is bilateral, progressively worsening, trouble hearing in noisy environments. Social hx: farmer exposed to loud noises, uses headphones often, cleans ears with Q-tips daily; normal Rinne’s and Weber’s tests
Workup?
CBC w/diff
Serum salicylate acid level
Audiogram
Patient is a 75 y/o M who has sudden onset of slurring speech.
Differential dx?
TIA
Cerebrovascular Accident
Subdural hematoma
Ruptured Aneurysm
Seizure
Workup for cerebrovascular accident and TIA differentials
Lipid panel (total cholesterol, LDL, HDL, TGs)
CBC w/diff
electrolytes
EKG
Carotid U/S
CT w/o contrast of head
MRI of brain
45 y/o M w. severe headache for the past 4 hours.
Possible Differentials?
Subarachnoid hemorrhage due to rupture aneurysm
Hypertensive crisis
substance-induced hemorrhage
Meningitis
45 y/o M with generalized headache, 10/10 sharp pain, aggravated by movement w/no relief from OTC meds.
ROS: +nausea
Social Hx: smokes 1-2 packs of cigarettes/day
FH: uncle w/PCKD
On PE: brudzinski test is +, hypertensive, afebrile, A+Ox2 (not sure of the date)
Possible dx?
Ruptured cerebral aneurysm (SAH)
45 y/o M with generalized headache, 10/10 sharp pain, aggravated by movement w/ no relief from OTC meds.
ROS: +nausea
Social Hx: smokes 1-2 packs of cigarettes/day, snorts cocaine
On PE: brudzinski test is +, hypertensive, A+Ox2 (not sure of the date)
Possible dx?
Cocaine-induced hypertensive intracranial hemorrhage
45 y/o M w/ generalized headache that he rates 10/10 intensity, aggravated by movement and no relief from OTC meds. ROS: +nausea
PE: A+Ox2 (cannot remember the date), hypertensive, bradycardia, brudzinski test +
*no papilledema or optic disc blurring on fundoscopy
Possible dx?
Meningitis
45 y/o M w/ generalized headache that he rates 10/10 intensity, aggravated by movement and no relief from OTC meds. ROS: +nausea
PE: A+Ox2 (cannot remember the date), hypertensive, bradycardia, brudzinski test +
*no papilledema or optic disc blurring on fundoscopy
Workup?
CBC w/diff
Urine toxicology
CT head w/o contrast
LP
MRI of brain
31 y/o F presents w/severe abd pain for the last 5 hrs.
Possible differentials?
Ectopic pregnancy
Appendicitis
Ruptured ovarian cyst
Spontaneous Abortion
Ovarian torsion
31 y/o f w. sudden onset of RUQ abd pain that is constant and dull; radiates to the back, alleviated by leaning forward. ROS: +nausea, vomiting (3 episodes)
FH: gallstones
Social Hx: heavy alcohol use
PE: voluntary guarding, tachycardia,f ever, SOB, TTP in RUQ, LUQ, and epigastrium
Possible dx?
Pancreatitis
31 y/o F w. sudden onset RUQ abd pain that is constant. ROS: nausea, vomiting, fever, SOB
FH: gallstones
PE: fever, tachycardia, RUQ pain, voluntary guarding
Possible dx?
Acute cholecystitis
31 y/o F w/ sudden onset of RUQ abd pain.
Meds: NSAID use daily
Social Hx: heavy alochol use
PE: tachycardia, diffusely tender abdomen, guarding
Possible dx?
Peptic ulcer disease
31 y/o F w/ sudden onset of RUQ abd pain.
Meds: NSAID use daily
FH: gallstones
Social Hx: heavy alochol use
PE: tachycardia, diffusely tender abdomen, guarding
Workup?
CBC w/diff
Electrolytes, glucose
lipase
AST, ALT, bilirubin, alkaline phos
U/S RUQ abd
CT scan of abd
EGD
30 y/o F w. recurrent diarrhea for the past year.
Possible differential?
Crohn’s disease
Ulcerative colitis
Celiac disease
Chronic infectious diarrhea
Irritable Bowel Syndrome
30 y/o F w/ diarrhea for one year; 10-20 BMs per day.
ROS: abdominal cramps, 20 lb weight loss, fever, arthralgias
PMH: fecal incontinence, perianal fistula
FH: uncle had partial gut resection
Possible dx?
Crohn’s disease
30 y/o F w/ diarrhea for one year; 10-20 BMs per day.
ROS: 20 lb weight loss, fever, arthralgias
PMH: fecal incontinence
FH: uncle had partial gut resection
Possible dx?
Ulcerative colitis
30 y/o F w/ diarrhea for one year; 10-20 BMs per day.
ROS: fever, occasional gross blood in stool
PMH: fecal incontinence
Possible dx?
chronic infectious diarrhea
30 y/o F w/ diarrhea for one year; 10-20 BMs per day.
ROS: abdominal cramps, 20 lb weight loss, fever, arthralgias
PMH: fecal incontinence, perianal fistula
FH: uncle had partial gut resection
Workup?
Rectal exam w/FOBT
CBC w/diff
Electrolytes
stool culture for ova, parasites, fecal leukocytes, stool antigen for E.histolytica
pANCA
Colonoscopy
55 y/o M w/ abd pain and yellow skin for the past 2 weeks.
Differential dx?
Viral Hepatitis
Alcoholic hepatitis
Acute pancreatitis
Hepatic failure
Patient is a 55 y/o M w/ jaundice, RUQ abd pain, choluria, acholic stools, fatigue.
Social hx: alcoholic, homeless, lives in a shelter
PE: thin, scleral icterus, jaundice, RUQ tenderness, -murphy’s sign, tender hepatomegaly
Possible dx?
Alcholic hepatitis
55 y/o M w/ jaundice, weight loss, choluria, acholic stools.
Social hx: IVDU of heroin, homeless/lives in a shelter, multiple sexual partners without condom use
Probable diagnosis?
Viral hepatitis (B or C)
55 y/o M w/jaundice, choluria, acholic stools, RUQ abd pain, anorexia.
Meds: acetaminophen use daily
PE: hepatomegaly, RUQ abd tenderness, jaundice, scleral icterus
Acetaminophen toxicity
55 y/o M w/jaundice, choluria, acholic stools, RUQ abd pain, anorexia.
Meds: acetaminophen use daily
PE: hepatomegaly, RUQ abd
Workup?
CBC w/diff
AST, ALT, alk phos, bilirubin, albumin, total protein
PT, PT, INR
HCV antibody, HCV PCR, HBsAg, HBV core Ab IgM
Acetaminophen level
RUQ U/S
66 y/o M w/worsening cough
Possible differential dx?
COPD exacerbation
CHF
PNA
66 y/o w/worsening cough, DOE, hemoptysis, 20 lb weight loss, fatigue
PMH: COPD
Social hx: 40 pack/yr smoking
PE: tachycardia, tachypnea, low pulse ox, scattered expiratory wheezes, decreased tactile fremitus
Possible dx?
lung cancer
66 y/o M w. worsening cough w/increased sputum production. ROS: fever, DOE, wheezing, chest tightness
PMH: COPD
Social Hx: 40 pack/yr smoking
Possible dx?
PNA
66 y/o M w/worsening cough w/increased sputum production, DOE, fever, and intermittent chest tightness.
PMH: COPD w/increased use of rescue inhaler
PE: tacyhcardia, tachypnea, low pulse ox sat, expiratory wheezes, decreased tactile fremitus, lack of dullness to percussion
Possible dx?
COPD exacerbation
66 y/o M w/worsening cough w/increased sputum production, DOE, fever, and intermittent chest tightness.
PMH: COPD w/increased use of rescue inhaler
PE: tacyhcardia, tachypnea, low pulse ox sat, expiratory wheezes, decreased tactile fremitus, lack of dullness to percussion
Workup?
CBC w/diff
Pulmonary function tests
sputum gram stain and culture
ABG
CXR
Blood cultures
EKG
60 y/o M w/intermittent blood in urine over the past month.
Possible differentials?
Bladder cancer
Prostate cancer
Urine discoloration due to medication side effect
Nephritis
urethral trauma
Patient is a 60 y/o M w/hematuria, blood present throughout micturition. ROS: polyuria, increased urinary urgency, weight loss
Social Hx: 60 pack yr smoking hx
Possible dx?
bladder cancer
60 y/o M w/hematuria.
PMH: recent pharyngitis, HTN
Possible dx?
poststreptococcal glomerulonephritis
60 y/o M w/hematuria. ROS: nocturia, polyuria, increased urinary urgency, weight loss
FH: dad had prostate cancer
Possible dx?
prostate cancer
Patient is a 60 y/o M w/hematuria, blood present throughout micturition. ROS: polyuria, increased urinary urgency, weight loss
Social Hx: 60 pack yr smoking hx
Work up?
Prostate exam
ASO titers
U/A
Urine culture
PSA
Urine cytology
Cystoscopy
1 y/o M w/diarrhea
Possible differentials?
viral gastroenteritis
bacterial gastroenteritis
Giardiasis
Food poisoning
1 y/o M w/irritability, blood diarrhea, recent travel hx, vomiting, fever, and sick contacts.
Possible dx?
bacterial gastroenteritis
1 y/o M w/irritability, watery diarrhea, low-grade fever, vomiting, daycare exposure
Possible dx?
Viral gastroenteritis
1 y/o M w/ irritability, watery/foul-smelling diarrhea, recent travel hx, vomiting
Possible dx?
giardiasis
1 y/o M w/irritability, blood diarrhea, recent travel hx, vomiting, fever, and sick contacts.
workup?
CBC w/diff
electrolytes
stool culture, test for ova, parasites, fecal leukocytes
Rotavirus enzyme immunoassay
43 y/o w/dizziness.
Possible differential?
BPPV
Acoustic neuroma
Meneiere’s disease
Intracranial tumor
43 y/o F w/episode vertigo, episodes lasts 20 minutes to a few hrs, tinnitus, hypoacusia, ataxia during episodes, nausea, vomiting, aural fullness.
PE: Weber test- lateralization to the right, normal Rinne test
Possible Dx?
Meniere’s disease
43 y/o F w/ episodic vertigo worse w/positional changes, ataxia during episodes, nausea, vomiting
PE: CNs 2-12 intact, motor strength 5/5, sensory intact
Possible dx?
Benign paroxysmal positional vertigo
43 y/o F w/ vertigo that progressively worsened over the last 6 months. ROS: tinnitus, hypoacusia, ataxia during episodes, aural fullness
PE: normal Rinne test, Weber test laterialziation to the right
Possible dx?
acoustic neuroma
43 y/o F w/ vertigo that progressively worsened over the last 6 months. ROS: tinnitus, hypoacusia, ataxia during episodes, aural fullness
PE: normal Rinne test, Weber test laterialization to the right
Workup?
Dix-Hallpike test
MRI of head
Audiogram
52 y/o M w/difficulty swallowing.
Possible differential?
Esophageal stricture
Achalasia
Esophageal cancer
Zenker diverticulum
52 y/o M w/progressive dysphagia to solids, 9lbs unintentional weight loss, sensation of food stuck in the throat
PMH: GERD
Social Hx: 30 pack yr smoking hx, drinks EtoH daily
PE: thin and cachetic
Possible dx?
esophageal cancer
62 y/o M w/ dysphagia of solids, regurgitation of food, unintentional weight loss
PMH: GERD
Possible dx?
Esophageal stricture
62 y/o M w/dysphagia, regurgitation of food at night, and unintentional weight loss.
Possible dx?
achalasia
52 y/o M w/progressive dysphagia to solids, 9lbs unintentional weight loss, sensation of food stuck in the throat
PMH: GERD
Social Hx: 30 pack yr smoking hx, drinks EtoH daily
PE: thin and cachetic
Workup?
CBC w/diff
Barium esophagram
EGD
Esophageal manometry
60 y/o M w/ SOB.
Possible differential?
Pulmonary embolism
MI
COPD exacerbation
Pleural effusion
Cardiac Tamponade
CHF exacerbation
Non-ischemic cardiomyopathy
60 y/o M w/ SOB. ROS: DOE, orthopnea, leg swelling, cough
PMH: HTN, DM II, HLD
FH: heart disease
Social hx: smoking hx
PE: spO2 of 90%, rales bilaterally, JVD, S3 gallop, HTN, +2 LE pitting edema bilaterally
Possible dx?
Congestive Heart Failure
60 y/o M w/ DOE, orthopnea, paroxysmal dyspnea, LE swelling, fevers.
Social Hx: cocaine use
PE: spo2 90%, rales bilaterally, JVD, S3 gallop, +2 LE pitting edema bilaterally
Possible dx?
Non-ischemic cardiomyopathy
60 y/o M w/ SOB. ROS: DOE, orthopnea, leg swelling, cough
PMH: HTN, DM II, HLD
FH: heart disease
Social hx: smoking hx, cocaine use
PE: spO2 of 90%, rales bilaterally, JVD, S3 gallop, HTN, +2 LE pitting edema bilaterally
Workup?
CBC w/diff
Electrolytes
BNP
EKG
CXR
Echocardiogram
Urine toxicology
45 y/o M w/chronic nose bleeds.
Possible differential?
ITP
Substance abuse induced nose bleeds
Immunodeficiency
Hemophilia A
Hemophilia B
Hepatic failure
Nutritional deficiency (vit K or C)
45 y/o M w/chronic nosebleeds. ROS: weight gain, decreased appetite, easy bruising, itchy skin, 2 episodes of heavy nose bleeding
Meds: excessive use of acetaminophen
Social hx: heavy drinking hx, sexually active w/multiple women w/o condom use
PE: jaundice, scleral icterus, multiple bruises, dullness to percussion of abd
Possible dx?
hepatic failure
45 y/o M w/chronic nosebleeds. ROS: easy bruising
Social Hx: poor diet, heavy drinking use
PE: poor dentition, thin extremities, multiple bruises
Possible dx?
nutritional deficiency (such as vit K or vit C)
45 y/o M w/recurrent episodes of epistaxis, two episodes of heavy bleeding and easy bruising.
PE: multiple bruises
Possible dx?
ITP
45 y/o M w/chronic nosebleeds. ROS: weight gain, decreased appetite, easy bruising, itchy skin, 2 episodes of heavy nose bleeding
Meds: excessive use of acetaminophen
Social hx: heavy drinking hx, sexually active w/multiple women w/o condom use
PE: jaundice, scleral icterus, multiple bruises, dullness to percussion of abd
Workup?
CBC w/diff
ASt, ALT, Alk phos, bilirubin, albumin, total protein
PT, PT, INR
U/S of RUQ
Vitamin C level
Acetaminophen level
14 y/o girl w/weight loss
Possible differential?
Anorexia Nervosa
Bulimia
Depression
Hyperthyroidism
14 y/o f w/ 25 lb intentional weight loss, exercising excessively, distorted body image, amenorrhea, laxative use
Possible dx?
anorexia nervosa
14 y/o f w/ 25 lb weight loss, amenorrhea, palpitations, and heat intolerance.
Possible dx?
hyperthyroidism
14 y/o f w/ 25 lb weight loss, amenorrhea, palpitations, and heat intolerance.
Workup?
Electrolytes
TSH, FT4, FT3
FSH, LH, prolactin
BUN, Cr
EKG
55 y/o M w/decreased energy for the past three years.
Differential?
Hypothyroidism
Depression
OSA
Iron deficiency anemia
55 y/o M w/ fatigue, weight gain, numbness in right hand, constipation, voice change, cold intolerance, impaired memory
FH: uncle has sjogren’s syndrome
PE: dry and scaly skin, decreased sensation in right hand, overweight
Possible dx?
hypothyroidism
55 y/o M w/ fatigue for the past 3 yrs, constipation, cold intolerance, leg cramps, impaired memory.
PE: dry and scaly skin
Possible dx?
iron deficiency anemia
55 y/o M w/ fatigue for the past 3 yrs, constipation, cold intolerance, leg cramps, impaired memory.
PE: dry and scaly skin, overweight
Workup?
rectal exam, FOBT
TSH, FT4
CBC w/diff
peripheral smear
ferritin levels
TIBC levels
serum FE
48 y/o F w/ abd pain.
Possible diff?
acute cholecystitis
acute pancreatitis
appendicitis
Peptic ulcer disease
Gastritis
48 y/o F w/diffuse abd pain w/hx of NSAID use and burning epigastric pain that is relieved by antacids.
Possible dx?
Peptic ulcer disease
48 y/o F w/intermittent, burning epigastric pain after meals. Relieved by milk and antacids. +intermittent nausea, +occasional vomiting
Meds: NSAIDs for arthritis, Maalox
Workup?
rectal exam, FOBT
U/S of RUQ
EGD
Urea breath test
AST, ALT, bilirubin
Lipase
21 y/o F w/ sudden abd pain, rated 7/10. LMP was 5 weeks ago. ROS: nausea, intermittent spotting
Social Hx: 3 sexual partners in last year, no condom use, STD one month ago
Workup?
Pelvic exam
Urine hCG
U/A
CBC w/diff
U/S of abd/pelvis
Cervical cultures
31 y/o F w/ sudden abd pain, rated 7/10. LMP was 5 weeks ago. ROS: nausea, intermittent spotting
Social Hx: 3 sexual partners in last year, no condom use, STD one month ago
Possible differential?
ectopic pregnancy
spontaneous abortion
appendicitis
PID
ruptured ovarian cyst
74 y/o M w/right arm pain in the upper and middle sections.
Possible differential?
humeral fracture
shoulder dislocation
elder abuse
rotator cuff tear
osteoporosis