Presentation work Flashcards
what is acetyl choline synthesised from, what is the enz and where does synth occur?
choline and acetyl~CoA choline acetyltransferase synth in particular neurons in central cholinergic areas
how is ACh packaged for use?
into individual vesicles by carrier prot on ves membrane called vesicular ACh transporter (VAChT)
how is ACh removed?
AChsterase degrades ACh -> acetate and choline
methacholine
test for asthma, as inhaling it can cause bronchoconstriction, but to a stronger degree it asthmatics
bethanechol
stims muscarinic effectors w/ no effect on nicotinic receptors used in peristaltic treatment to induce activity
why are muscarinic cholinoceptor antagonists used for GI disorders?
stop GI spasms and hypermotility eg dicycloverine
why are muscarinic cholinoceptor antagonists used for premedication?
bronchodilation, protect from vagal stim on heart eg atropine
where do the para/sympathetic NSs connect to the eye?
ciliary ganglion, only the PaSyNS synapses here
possible causes of glaucoma
inc in intraocular pressure due to accum on aq humour/fluid -> compression of optic nerve -> this can be due to diabetes -> inc glucose -> inc intraocular fluid pupil dilation impedes drainage of humour by blocking Schlemm’s Canal
synthesis of adrenaline
what determines whether an axon is dopaminergic/adrenergic?
whether it has dopamine bet-hydroxylase
how is NAdr packaged for release?
vesicular monoamine transporter (VMAT)
adrenoceptors of liver, vascular, airways, GI, bladder, SAN, ventricle, adipose tiss, skel muscle and iris
alp1 and bet2, alp1 and bet2, bet2, bet2, alp1 and bet2, bet1, bet1, bet1/3, bet2, alp1
which receptors do N/Adr act best on?
NAdr best on alp
Adr best on bet
best drug for reversal of bronchoconstriction in asthmatics
salbutimol, acts on bet 2
