Presentation work Flashcards

1
Q

what is acetyl choline synthesised from, what is the enz and where does synth occur?

A

choline and acetyl~CoA choline acetyltransferase synth in particular neurons in central cholinergic areas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

how is ACh packaged for use?

A

into individual vesicles by carrier prot on ves membrane called vesicular ACh transporter (VAChT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how is ACh removed?

A

AChsterase degrades ACh -> acetate and choline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

methacholine

A

test for asthma, as inhaling it can cause bronchoconstriction, but to a stronger degree it asthmatics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

bethanechol

A

stims muscarinic effectors w/ no effect on nicotinic receptors used in peristaltic treatment to induce activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

why are muscarinic cholinoceptor antagonists used for GI disorders?

A

stop GI spasms and hypermotility eg dicycloverine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

why are muscarinic cholinoceptor antagonists used for premedication?

A

bronchodilation, protect from vagal stim on heart eg atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

where do the para/sympathetic NSs connect to the eye?

A

ciliary ganglion, only the PaSyNS synapses here

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

possible causes of glaucoma

A

inc in intraocular pressure due to accum on aq humour/fluid -> compression of optic nerve -> this can be due to diabetes -> inc glucose -> inc intraocular fluid pupil dilation impedes drainage of humour by blocking Schlemm’s Canal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

synthesis of adrenaline

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what determines whether an axon is dopaminergic/adrenergic?

A

whether it has dopamine bet-hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

how is NAdr packaged for release?

A

vesicular monoamine transporter (VMAT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

adrenoceptors of liver, vascular, airways, GI, bladder, SAN, ventricle, adipose tiss, skel muscle and iris

A

alp1 and bet2, alp1 and bet2, bet2, bet2, alp1 and bet2, bet1, bet1, bet1/3, bet2, alp1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which receptors do N/Adr act best on?

A

NAdr best on alp

Adr best on bet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

best drug for reversal of bronchoconstriction in asthmatics

A

salbutimol, acts on bet 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

best drug to prolong action of local anaesthetic

A

adrenaline, alp/bet agonist

17
Q

propranolol uses

A

bet adrenoceptor antagonist

angina, MI, dysrhythmias, heart faliure, hypertension, glaucoma

18
Q

what enz is inhibited by alp-methyltyrosine?

A

comp inhibitor of Tyr hydroxylase, -> no NAdr made

19
Q

how is cancer of chromaffin cells treated?

A

alp-methyl tyrosine

20
Q

role of alp-methyl DOPA

A

comp inhibits DOPA carboxylase