Presentación de antígenos Flashcards

1
Q

Qué es MHC?

A

Complejo mayor de histocompatibilidad

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2
Q

Qué es HLA?

A

Antígeno leucocitario humano

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3
Q

Cromosoma en que se encuentra el HLA?

A

Cromosoma 6

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4
Q

Clases de HLA

A

Clase I y II

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5
Q

Genes que codifican HLA clase I

A

A, B, C

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6
Q

Genes que codifican para clase II

A

DP, DQ,DR

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7
Q

Estructura del HLA clase I

A

1 cadena alfa (2 dominios)+beta 2 microglobulina

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8
Q

Sitios de unión del HLA clase I

A

a1 y a2

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9
Q

Estructura del HLA clase II

A

1 cadena alfa (2 dominios)+1 cadena beta (2 dominios)

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10
Q

Sitios de unión de la HLA clase II

A

a1 y B1

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11
Q

HLA que se relaciona con narcolepsia

A

HLA DR2

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12
Q

HLA que se expresa en espindilitis anquilosante

A

HLA B27

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13
Q

HLA que se relaciona con autoinmunidad

A

HLA B6

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14
Q

Células que cuentan con HLA clase I

A

Células nucleadas

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15
Q

Células que cuentan con HLA clase II

A

Células inmunológicas

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16
Q

Tipos de células presentadoras de antígenos

A

Profesionales y facultativas

17
Q

Células presentadoras de antígenos profesionales

A

Células dendríticas, de langerhans y CPA (macrófagos especializados)

18
Q

Células presentadoras de antígenos facultativas

A

Linfocitos B, macrófagos y células epiteliales