prescription review

Question 1

drugs that cause dry cough

Answer 1

ACEi (RAAS -> inc bradykinin)

methotrexate (induced pneumonitis)

Question 2

beta-blocker + verapamil

Answer 2

sudden hypotension and asystole (rip)

Question 3

postural hypotension

Answer 3

tamsulosin (alpha blockade)

acei

isosorbide mononitrate (venodilation)

Question 4

what interacts with levothyroxine

Answer 4

ferrous fumarate

Question 5

lithium toxicity

Answer 5

cerebellar dysfunction (nystagmus and dysmetria)

hyperthermia

hypernatraemia

Question 6

drugs that case hypernatraemia

Answer 6

loop and thiazide diuretics

lithium

Question 7

citalopram

Answer 7

max dose for adults: 40mg

max dose for >65 or hepatic impairment: 20mg

Question 8

amiodarone and venlafaxine

Answer 8

interact with each other

arrange annual ECGs, check BP and pulse

Question 9

breast feeding safe drugs

Answer 9

metformin

sulfonylurea - glibenclamide

Question 10

breast feeding avoid drugs

Answer 10

aspirin - reyes syndrome

ciprofloxacin (quinolone) - arthropathy

lisinopril

Question 11

clozapine adverse effects

Answer 11

an atypical antipsychotic

dopaminergic effects

metabolic syndrome (polydipsia, polyuria, blurred vision)

Question 12

digoxin loading dose

Answer 12

oral 500 mcg, daily

Question 13

doxycycline loading dose

Answer 13

oral 200 mg, daily

Question 14

cytochrome p450 inducers

Answer 14

Phenytoin

Carbamazepine

Barbiturates

Rifampicin

Alcohol (chronic excess)

Sulphonylureas

Question 15

cytochrome p450 inhibitors

Answer 15

Allopurinol

Omeprazole

Disulfiram

Erythromycin

Valproate

Isoniazid

Ciprofloxacin

Ethanol (acute intoxication)

Sulphonamides

Question 16

DRESS

“drug reaction with eosinophilia and systemic symptoms”

Answer 16

allopurinol

anti epileptics: carbamazepine

sulphonamides: co - trimoxazole