Prescribing in the Elderly

Question 1

What are the ADME principles of pharmacokinetics?

Answer 1

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Question 2

What environment do acidic drugs require for absorption?

Answer 2

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Question 3

What environment do basic drugs require for absorption?

Answer 3

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Question 4

What is the acid content like in the stomachs of elderly patients?

Answer 4

Less acidic

Means it will absorb more basic drugs

Question 5

What factors can affect absorption?

Answer 5

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Question 6

What does albumin bind to?

Answer 6

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Question 7

What does Alpha-1 Glycoprotein bind to?

Answer 7

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Question 8

What are albumin and A-1 AG levels like in the elderly?

Answer 8

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Question 9

What is the volume of distribution?

Answer 9

Theoretical volume

The higher the Vd the more likely the drug has a long half life and is lipid soluble

Question 10

Why do drugs stay in the system longer in older patients?

Answer 10

Decreased renal and hepatic clearance

Question 11

How is hepatic metabolism affected in the elderly?

Answer 11

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Question 12

How is renal metabolism affected in the elderly?

Answer 12

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