Prescribing errors Flashcards

1
Q

Define a medication error

A

“any preventable event that may cause or lead to inappropriate medication use or patient harm”

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2
Q

When are medication errors more likely?

A
  • Inexperienced
  • Inattentive
  • Rushed
  • Distracted
  • Tired
  • Depressed
  • Orthopaedic surgeons,
  • Work in paediatrics
  • Work in intensive care units
  • With elderly people
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3
Q

What is a prescribing error?

A

A clinically meaningful prescribing error occurs when, as a result of a prescribing decision or prescription writing process, there is either an unintentional significant:
o Reduction in the probability of treatment being timely and effective
o Increase in the risk of harm when compared with generally accepted practice.

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4
Q

What is a prescribing fault?

A

Prescribing Faults - failures in the process of deciding which drug to use and how

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5
Q

What is a prescription error?

A

Prescription Errors - failures in the prescription writing process that result in wrong instructions about one or more of the normal features of a prescription

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6
Q

Which tasks are intrinsically prone to error?

A

– Tasks that are unfamiliar to the operator or performed under pressure.
– Tasks that require the calculation of a dosage or dilution are especially susceptible to error.

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7
Q

Why do medication errors happen?

A
•	Increase in numbers and variety of drugs
•	Patients have co-morbidities
•	Complexity of care process
–	Specialists
–	Care settings
–	Care delivery paths/journeys
•	Need for high risk medications
•	Number of prescribers
•	OTC usage 
•	Loss of the generalist in charge of the patient
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8
Q

Describe some causes of errors in prescription writing

A

Wrong drug (sound similar)
Illegibility
Inappropriate abbreviation use

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9
Q

What can cause errors in decision making?

A

Poor understanding of medical history
Poor knowledge of drug properties
Poor knowledge of DDIs

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10
Q

What are the current issues with ageing and pharmacotherapy?

A
  • Under-representation in clinical trials
  • Multiple co-morbidities
  • Multiple prescribers
  • Polypharmacy: Drug Interactions
  • Prescribing cascade
  • Altered pharmacokinetics and pharmacodynamics
  • Adverse drug reactions
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11
Q

How can you minimise the risk of improper decision making?

A

• Before prescribing, consider:
– The patient’s medication history
– Other factors that might alter the benefits and risks of treatment
• Select effective, safe, and cost-effective medicines individualised for the patient
• Adhere to national guidelines and local formularies
• Monitor the beneficial and adverse effects of medicines
• Communicate and document prescribing decisions
• Prescribe within the limitations of your knowledge, skills and experience

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12
Q

What are the consequences of prescription errors?

A
  • Patient & family grief
  • Colleagues: Staff/ multidisciplinary team
  • Professional consequences
  • Legal consequences
  • Media
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13
Q

What are the 5 Rs?

A
• The 5 Rs
–	Right patient
–	Right drug
–	Right route
–	Right time
–	Right dose
• 6th R: Formulation?
–	Sustained Release Preparations 
–	 Drugs that must be prescribed by brand
–	Changing between formulations
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14
Q

How can we enhance safe prescribing?

A
•	Use of patient passports
•	Medicines reconciliation
•	Use of technology
•	Use of simulation for rehearsal 
–	Drug history: allergies
•	Development of standards of practice
–	Five  “rights” - Right patient, drug, dose, route and time 
•	Handover
•	Reporting system 
•	Communication techniques
•	Design of safe delivery systems
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15
Q

Name some common anti epileptic enzyme inducers

A

Phenytoin
Carbamazepine
Primidone

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16
Q

Name some common antidepressant enzyme inducers

A

St Johns wort

17
Q

Name a GI drug enzyme inducers

A

Omeprazole

18
Q

Name some common antibacterial enzyme inhibitors

A
Clarithromycin
Erythromycin
Ciprofloxacin
Isoniazid
Metronidazole
19
Q

Name some common cardiovascular drug enzyme inducers

A

Amiodarone
Verapamil
Diltiazem
Quinidine

20
Q

Name some common antidepressant enzyme inhibitors

A

Fluoxetine
Fluvoxamine
Paroxetine
Sertraline

21
Q

Name some common anti fungal enzyme inhibitors

A

Fluconazole
Ketaconazole
Miconazole
Itraconazole

22
Q

How does smoking, rifampicin and isoniazid affect liver enzymes?

A

Inducers

23
Q

Name some anti-rheumatic drugs that are enzyme inhibitors

A

Allopurinol

Azapropazone

24
Q

Name some anti-viral enzyme inhibitors

A

Indinavir
Ritonavir
Saquinavir

25
Q

How do disulfam and sodium valproate affect drug metabolising enzymes?

A

Inhibitors