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BIOPHARM > PREMID > Flashcards

PREMID Flashcards

1
Q

buccal drug delivery systems are used for both sublingual and buccal drug
delivery

A

FALSE

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2
Q

injection of a drug directly into the patient’s veins is the most rapid route of
administration, resulting in the most rapid onset of action.

A

Intravenous

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3
Q

injected deeply into muscle tissue

A

Intramuscular

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4
Q

administered by mouth

A

Oral

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5
Q

This route is convenient to use in children or in patients who are unconscious or vomiting.

A

Rectal

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6
Q

are applied to a surface area of the body

A

Dermal

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7
Q

The drug is absorbed through the skin into the bloodstream. -Systemic Effect

A

TRUE

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8
Q

Process by which a chemical or drug becomes dissolved in a solvent

A

Dissolution

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9
Q

Major transmembrane process for most drug

A

Passive Diffusion

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10
Q

The effect of reduced particle size of a drug is:

A

a. increased absorption

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11
Q

Dissolution rate tests can be used to predict bioavailability if:

A

a. dissolved drug remains free in the GIT

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12
Q

Differences in bioavailability are most
frequently observed with drugs are
administered by which of the ff.
routes

A

Oral

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13
Q

The major pathway of excretion

A

via the kidney

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14
Q

The rate of diffusion of drug across biological membranes is most commonly:

A

directly proportional to the concentration gradient

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15
Q

The rectal route of administration may be preferred over the oral route for some drug because:

A

a portion of the absorbed drug does not
pass through the liver before entering the systemic circulation

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16
Q

The process that determines absolute
bioavailability are the first pass effect and:

A

Absorption

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17
Q

In LADMER system, L stands for liberation as the first step which determines the following aspects, except:

A

Type of Preparation

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18
Q

The ultimate evaluation of dosage forms or delivery system is in:

A

Clinical effectiveness

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19
Q

A rate limiting factor in the dissolution of
drugs is: a. disintegration of the tablet

A

TRUE

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20
Q

A rate limiting factor in the dissolution of
drugs is:

A

Disintegration of tablet

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21
Q

The effect of reduced particle size of a drug is: all of them

A

NO

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22
Q

The effect of reduced particle size of a drug is:

A

Increased Absorption

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23
Q

Tmax means:

b. peak height concentration

A

NO

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24
Q

Tmax means:

A

Time of Peak Concentration

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25
Q

The purpose of biotransformation reaction is:
a. deactivate the drug
b. preserve the drug from destruction
c. promote elimination of inactive drug
d. a & c
answer -d

A

YES

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26
Q

The advantage of sublingual/buccal
administration is:

A

a. no occurrence of gastrointestinal
degradation

c. not pass to the liver

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27
Q

A site in the biophase to which drug
molecules can be found is:

A

Receptor

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28
Q

The rectal route of administration may be preferred over the oral route for some drug because:

A

a portion of the absorbed drug does not
pass through the liver before entering the systemic circulation

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29
Q

The rectal route of administration may be preferred over the oral route for some drug because: b. absorption is predictable and complete

A

NO

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30
Q

it classifies drugs into four classes according to their ———- across the gastrointestinal pH range and their ————— across the gastrointestinal mucosa.

answer solubility and permeability

A

YES

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31
Q

Solubility and permeability are considered as the major physicochemical factors that affect
the rate and extent of oral drug absorption.

A

YES

32
Q

If the volume of aqueous media taken to
dissolve the drug in pH conditions ranging from 1 to 8 is greater than 250 mL then the drug is considered to have ———-
answer is high solubility

A

NO

33
Q

If the volume of aqueous media taken to
dissolve the drug in pH conditions ranging from 1 to 8 is greater than 250 mL then the drug is considered to have ———-
answer is low solubility

A

YES

34
Q

which class of the BCS is the following?
High solubility/high permeability
Dissolve rapidly when presented
in immediate-release dosage forms.
Rapidly transported across the gut wall.
Rapidly absorbed = good bioavailability.

BCS class I Drugs

A

YES

35
Q

which class of the BCS is the following?
• Hydrophilic molecules (high aqueous
solubility) with low permeability across the biological membranes.

answer is BCS Class IV drugs

A

NO

36
Q

which class of the BCS is the following?
• Hydrophilic molecules (high aqueous
solubility) with low permeability across the biological membranes.

answer is BCS Class III drugs

A

YES

37
Q

design feature of the dosage form that affects the delivery of the drug; such a system may protect the stomach or delay the release of the active

Drug Delivery System

A

TRUE

38
Q

dosage form that contains a special coating designed to delay absorption of the medication and to resist breakdown by acidic gastric fluids

  • delayed-release (DR) formulations
A

TRUE

39
Q

tablet or capsule designed to reduce
frequency of dosing compared with
immediate-release and most sustained-
release formulations

A

extended-release (XL) formulation

40
Q

science that examines interrelationship of physiochemical properties of drug, dosage form in which drug is given, and route of admin on rate and extent of systemic drug absorption

-Biopharmaceutics

A

TRUE

41
Q

study of adverse effects of drugs and toxic substances in body

A

Clinical toxicology

42
Q

difference between onset time and time at which drug declines back to MEC

A

Duration of Drug action

43
Q

Branch of medicine and biology concerned with the study of drug action

A

Pharmacology

44
Q

Pharmacology can mainly be divided into two main areas, namely

A

Pharmacokinetics and
Pharmacodynamics

45
Q

LADMER process can be divided into 2: -Drug Input and Drug output

A

TRUE

46
Q

input process

A

Liberation and Absorption

47
Q

release of drug from its dosage form

A

Liberation

48
Q

biopharmaceutics involves factors that
influence:
o stability of drug within drug product
o release of drug from drug product
o rate of dissolution/release of drug at
absorption site
o systemic absorption of drug

A

ALL

49
Q

In LADMER system, L stands for liberation as
the first step which determines the following
aspects, except:
a. onset of action c. rate of absorption
b. type of preparation
d. bioavailability

A

type of preparation

50
Q

The termination of action of a drug is
determined by:
a. excretion of intact active molecule c. tissue
redistribution
b. excretion of active molecule d. a & c

A

D

51
Q

The rate and extent at which the drug appears in the bloodstream is known as:

A

Bioavailability

52
Q

The principal site of drug metabolism is:

A

liver

53
Q

The first step which determines the onset of
action, rate of absorption, availability is:

A

liberation

54
Q

Which is the following factors affect the
dissolution in the lipid membrane of the lipid
soluble unionized fluid
compartment:
a. pH c. lipid/water partition coefficient
b. pKa d. all of the above

A

D

55
Q

When considering drug transport, ‘a passive
transport process’ implies that:

a. all of the drug will pass from one
compartment to another
b. the process requires energy
c. The net transfer of drug is from an area of high concentration to an area low concentration
d. the net transfer of drug is from an area of low concentration to an area of high concentration

A

C

56
Q

Reabsorption of the drugs and its metabolite
occurs in the
a. kidney c. both a & b
b. intestines d. none of the above

A

C

57
Q

Gastric emptying is slowed down by the
following except:
a. a vigorous exercise c. hot meals
b. fatty foods d. hunger

A

D

58
Q

Oral dosage forms are widely used due to the convenience of drug administration.

A

TRUE

59
Q

Orally bioavailable means that a drug or other substance that is taken by mouth can be absorbed and used by the body.

A

TRUE

60
Q

Plendil ER is an example of release
delayed tablet

A

FALSE

61
Q

Liberation is the first step in determining
onset of action, rate of absorption, availability

A

TRUE

62
Q

A drug administered in a dosage form by any route of administration must be released from the dosage form (except IV, and true solutions
for other routes).

A

TRUE

63
Q

A lower pKa value indicates a weak acid.

A

FALSE

64
Q

A higher pKa value indicates a stronger acid.

A

FALSE

65
Q

Most of the drugs are absorbed or
transported by passive diffusion, depends

A

lipid solubility

66
Q

iN THE LADMER SYSTEM D IS

A

Distribution

67
Q

WHAT THE PHARMACEUTICAL SCIENTIST
DOES TO THE DRUG REFERS TO

A

BIOPHARMACEUTICS

68
Q

deals with the study of physiochemical and physiological factors that influence the liberation and absorption of drugs from different dosage forms

A

BIOPHARMACEUTICS

69
Q

the two most important biopharmaceutical properties that influence drug absorption and oral bioavailability.

A

DRUG SOLUBILITY AND PERMEABILITY

70
Q

as the amount of drug that passes into
solution when an equilibrium is established between the drug solute in solution and any excess, un-dissolved drug to produce a saturated solution at a specified temperature

A

DRUG SOLUBILITY

71
Q

THE STUDY OF DRUG RESPONSE

A

Pharmacodynamics

72
Q

The ability of a drug or other substance to be absorbed and used by the body

A

BIOAVAILABILITY

73
Q

WHICH OF THE FOLLOWING STATEMENT IS TRUE?
o In order for a drug to be absorbed, it
must be present in the form of
solution
o After dissolution, the drug diffuses to
the site of absorption
o Only drugs administered
intravenously in solution enter the
circulatory system immediately.

A

o ALL THE ABOVE IS TRUE

74
Q

In the liver, the main place of metabolism, some drugs are inactivated and metabolized during the first pass; other drugs are activated here

A

TRUE

75
Q

Poor biopharmaceutical and pharmacokinetic properties can affect drug responses.

A

true

76
Q

Drugs with good aqueous solubility and
membrane permeability generally show good oral absorption and bioavailability provided the drug is stable in the gastrointestinal tract and does not undergo first-pass metabolism
in the liver

A

true

BIOPHARM (1 decks)

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