Premenstrual syndrome Flashcards
First line medications for premenstrual dysphoric disorder
SSRIs
Antidepressants used for premenstrual dysphoric disorder
Fluoxetine
Sertraline
Paroxetine
Citalopram
Escitalopram
Venlafaxine
Clomipramine
Percentage of women of reproductive age who suffer from premenstrual dysphoric disorder
2-8%
Percentage of women of reproductive age who suffer from at least one mild premenstrual symptom
85%
Antidepressant which has the most evidence base for use in premenstrual dysphoric disorder
Fluoxetine
Most severe symptoms seen in premenstrual dysphoric disorder
Anxiety and irritability
Core symptoms of premenstrual dysphoric disorder
Depressed mood
Marked anxiety
Marked affective lability
Marked anger or irritability
Symptoms of premenstrual dysphoric disorder which usually starts earliest
Anger and irritability
Timing of symptoms of premenstrual dysphoric disorder
Occur during the luteal phase
Peak of symptoms of premenstrual dysphoric disorder
2 days before period starts
Length of time after starting when SSRIs have an effect on premenstrual dysphoric syndrome
Within one menstrual cycle
Two timing options for medication to treat premenstrual dysphoric syndrome
Continuous
Intermittent - used only in the luteal phase or only in the few days when symptoms are worst
Response to continuous vs. intermittent dosing of SSRIs to treat premenstrual dysphoric syndrome
Intermittent dosing showed fewer side effects
Continuous dosing more effective for somatic complaints
Overall no difference for mood
Difference in response to SSRIs for premenstrual dysphoric disorder compared to depression
Quicker response for premenstrual dysphoric disorder
Difference in adverse effects when SSRIs used for premenstrual dysphoric disorder compared to depression
Fewer sexual side effects when used for premenstrual dysphoric disorder
No akathisia when used for premenstrual dysphoric disorder
No increased suicidal ideation when used for premenstrual dysphoric disorder
