Prelims

Question 1

Palmar xanthomas are common signs of patient with:

Answer 1

Familial hypercholesterolemia

Question 2

Atherosclerosis is triggered by an injury to the endothelium caused by the following factors, except:
a. increased serum lipid levels
b. increased blood pressure
c. increased glucose levels
d. increased oxidative agents
e. none of the these

Answer 2

e

Question 3

What is the first step in triglyceride test?

Answer 3

hydrolysis of FA esters

Question 4

Which of the following apolipoproteins is not found in VLDL?
a. Apo A4
b. Apo B100
c. ApoC3
d. Apo E
e. None of theses

Answer 4

e

Question 5

Which of the following serum proteins migrates to beta-globulin fraction?

Answer 5

complement

Question 6

Lipids are stored in lipid droplets of cells as:

Answer 6

triglycerides and cholesterol esters

Question 7

The following causes decreased albumin concentration, except:
a. tissue injury
b. acute inflammation
c. nephrotic syndrome
d. acute liver failure
e. None of these

Answer 7

e

Question 8

Which level of protein structure is unlikely to be affected significantly by change in pH?

Answer 8

Primary

Question 9

Signal recognition particles direct which of the following processes in protein synthesis?

Answer 9

Translocation

Question 10

Apo C3 is found in the following lipoproteins, except:
a. chylomicrons
b. VLDL
c. LDL
d. HDL
e. none of these

Answer 10

c. LDL

Question 11

Which of the following statements incorrectly describe foam cells?
a. Foam cells are macrophages filled with oxidized LDL.
b. Foam cells are early precursors of atherosclerosis.
c. Foam cells form fatty streaks undereath the endothelium of arteries.
d. Foam cell formation is stimulated by cytokines released by T cells.
e. None of these.

Answer 11

d. Foam cell formation is stimulated by cytokines released by T cells.

Question 12

The following are transporter proteins, EXCEPT:
b. Haptoglobin
c. Transferrin
a. Albumin
e. Adiponectin
e. None of these

Answer 12

e. None of these

Question 13

Which of the following amino acids absorb light at 255nm?
b. Tryptophan
c. Phenylalanine
d. All of these.
e. None of these

Answer 13

c. Phenylalanine

Question 14

Complement C3 has an isoelectric point of 5.7. During serum protein electrophoresis using a buffer with a pH
of 3, which of the following would happen?
a. Complement C3 will have a positive net charge and move towards the cathode.
b. Complement C3 will have a negative net charge and move towards the anode.
c. Complement C3 will have a no net charge and will not move from the point of application.
d. Complement C3 will have a negative net charge and move towards the cathode.
e. Complement C3 will have a positive net charge and move towards the anode.

Answer 14

a. Complement C3 will have a positive net charge and move towards the cathode.

Question 15

75. Which of the following statements is incorrect?
    a. a1-Acid glycoprotein is decreased in acute myocardial infarction.
    b. a1-Fetoprotein is a tumor marker for liver cancer among adults.
    c. Albumin appears to be increased when patient is dehydrated.
    d. Deficiency in a1-antitrypsin can lead to alveoli damage.
    e. None of these.

Answer 15

a. a1-Acid glycoprotein is decreased in acute myocardial infarction.

Question 16

A patient has a high reticulocyte count and unconjugated bilirubin serum levels. The doctor highly suspects nemolytic anemia as the cause of these results. He ordered measurement of the patient’s haptoglobin level which turned out to be within the normal range. What can be concluded based on these results? difficult
a. The patient has extravascular hemolysis.
b. The patient has liver damage.
c. The patient has intravascular hemolysis
d. The patient’s sample was hemolyzed during phlebotomy.
e. None of these.

Answer 16

a. The patient has extravascular hemolysis.

Question 17

The plasma levels of the following proteins are normally increased in pregnant women, EXCEPT:
a. Ceruloplasmin
b. a2-macroglobulin
c. al-acid glycoprotein
d. a1-fetoprotein
e. a1-antitrypsin

Answer 17

d. a1-fetoprotein

Question 18

The following will decrease serum levels of ceruloplasmin, EXCEPT:
a. malnutrition
b. nephrotic syndrome
c. Menke’s syndrome
d. inflammation
e. liver cirrhosis

Answer 18

d. inflammation

Question 19

This classification of hyperlipidemia has elevated levels of triglyceride, total cholesterol, VLDL and chylomicrons but with low risk for coronary vascular disease.
a. Type 1
b. Type 2b
с. Type 3
d. Type 4
e. Type 5

Answer 19

e. Type 5

Question 20

The following statements are true regarding the analysis of aminoacidopathies, EXCEPT:
a. Urine samples cannot be used to diagnose AAopathies.
b. Blood samples should be collected using heparinized tubes.
c. Fasting of 8 hours is required prior to sample collection.
d. Whole blood sample can be used as long as not hemolyzed.
e. None of these.

Answer 20

a. Urine samples cannot be used to diagnose AAopathies.

Question 21

The following amino acids are proton acceptor, EXCEPT:
a. Lysine
b. Histidine
c. Asparagine
d. Two of these.
e. None of these.

Answer 21

c. Asparagine

Question 22

In the chemical precipitation method for HDL, which of the following chemicals neutralizes the lipoproteins causing these to aggregate together forming an insoluble compound?
a. Heparin
b. Magnesium ions
c. Dextran sulfate
d. Chloride ions
e. 4-amino antipyrine

Answer 22

b. Magnesium ions