pregnancy complications Flashcards
dystocia definition
failure to progress labor, prolonged labor
3 P’s of labor
Power (cervical dilation/contractions/descent, 25 mmHg pressure, min 3 contractions/10min)
Passenger (excess fetal wt, presentation, lie)
Passage (pelvis)
1st stage disorders
latent phase (onset-4cm dilation) >20 hrs null, >14 hrs multi
active phase (4-10cm dilation) dilation <1.2-1.5 cm/hr multi
augmentation in 1st stage prolongation
oxytocin (incr contractions)
amniotomy (rupture membranes)
2nd stage disorders
> 3 hrs if anesthesia
>2 hrs if no anesthesia
Tx of prolonged 2nd stage labor
C section
forceps
vacuum extraction
shoulder dystocia maneuvers
McRoberts maneuver
mom’s thighs hyperflexed against abdomen
pressure over lower abdomen
episiotomy
shoulder dystocia injuries
- brachial plexus injury
- Erb Duchenne palsy: tear C5, C6; arm paralysis, motor movement hand intact
- Klumpke paralysis: C8-T1 tear; hand paralysis
acceleration fetal HR means?
- NORMAL
- normal with fetal scalp stim/vibroacoustic stim test
early deceleration fetal HR means?
-physiologic, occurs with uterine contractions (decr blood flow to fetus, hypoxia)
late deceleration fetal HR means?
- FETAL HYPOXIA
- uteroplacental insufficiency
meconium aspiration: risk of developing what?
pneumonitis, pneumothorax
meconium aspiration Tx
immediate suction, intubation
MCC maternal death
postpartum hemorrhage
when does postpartum hemorrhage occur?
1st 24 hrs
causes of postpartum hemorrhage
MCC: uterine atony retained placenta coag disorders ruptured uterus inverted uterus genital tract trauma hematomas
uterine atony
no constriction of arteries at site of placental separation to stop bleeding
RF for uterine atony
stretched uterus
polyhydramnios, twins, abnorm labor
uterine atony Sx
boggy uterus (normally firm)
Tx uterine atony
contractions!
- manual massage (short term)
- immediate breastfeeding
- methylergonovine maleate
- prostaglandins: misoprostol
- surgery: compression sutures, selective artery embolization
retained placental tissue definition
sheared/torn cotyledons
placenta: missing cotyledons
cause of retained placental tissue
abnorm adherence, incomplete placenta separation
abnormal adherence causing retained placental tissue: placenta accreta / increta / percreta
superficial lining of uterus
uterine muscle
entire thickness of muscle, no separation at all
Tx retained placental tissue
currettage
hysterectomy
uterine inversion cause, Tx
- tug umbilical cord during placental delivery
- manually replace
uterine rupture RF, Tx
RF: uterine surgery/procedure, C section
Tx: hysterectomy
amniotic fluid embolism cause, Sx
amniotic fluid into maternal circulation
-resp distress–> cyanosis–> CV collapse–> hemorrhage/coag DIC–> coma
ectopic MC site
fallopian tube
RF for ectopic
- tubal ligation/tubal surgery
- Hx ectopic
- IUD
- DES exposure (diethylstillbestrol)
- PID
- infertility Tx
- endometriosis (scar, adhesions)
- tobacco
DES assoc with
vaginal clear cell carcinoma, ectopic, miscarriage, breast CA
Sx ectopic
amenorrhea, vaginal bleeding, abdom pain on affected side
adnexal tenderness
DDx ectopic
abortion, ovarian cyst rupture, renal calculi, appendicitis
differentiate DDx ectopic
amenorrhea not in appendicitis/renal calculi
appendicitis- RLQ pain
Dx ectopic
- serum HCG: lower than expected
- transvaginal US: no gestational sac, free fluid pouch of Douglas, echogenic adnexal mass
(decr progesterone = nonviable preg; blood in cul-de-sac)
gestational sac visualized 1000-2000 IU/L
Tx ectopic
methotrexate (abort, folic antagonist, stops rapidly dividing cells)
surgery if needed (salpingostomy)
spontaneous abortion / miscarriage definition
expulsion before 20 wks gestation
early miscarriage cause
chromosomal abnorm (trisomy)
2nd trimester miscarriage cause
maternal systemic dz, placental abnorm
RF for miscarriage
infection (chlamydia, syphilis, HIV, GBS), thryoid autoAb/hypothyroidism, DM 1, smoking, radiation, coag disorders, uterine leiomyomata, Hx DES
threatened abortion
BLEED WITHOUT TISSUE LOSS, bleeding then cramping days later
risk of preterm delivery, low birth wt
inevitable abortion
gross rupture membranes, cervical dilation
classifications of spontaneous abortion
complete, incomplete, missed
complete spontaneous abortion
<10 wks, everything expelled
incomplete spontaneous abortion
later in preg, not everything expelled, tissue partially protrude through cervix, remove with forceps/suction
missed spontaneous abortion
retained failed intrauterine preg for months, no uterine growth, loss of early preg Sx, resolve spontaneously
medical induced abortion when?
< 49 days
induced abortion how for <49 days?
antiprogestin (mefepristone), methotrexate, prostaglandin (misopristol)
induced abortion how for >49 days?
surgical- suction currettage
concerning finding in fetal HR monitoring?
late decelerations
hydatidiform mole (partial? complete?)
partial: 1 egg, 2 sperm
non viable, recognize fetal material
69 XXX, XXY
complete: egg without DNA, 2 sperm
NO recognize fetal material
46 XX, XY
gestational trophoblastic neoplasia aka
hydatidiform mole
range of neoplasms from trophoblastic tissue
gestational trophoblastic neoplasia / hydatidiform mole Sx
neoplasia = grows out of control
- vaginal bleeding, pain, hyperemesis gravidarum
- uterine enlargement, ovarian enlargement (TLC), no fetal HR
- HTN!! (if <20 wks), EXCESSIVE HCG
gestational trophoblastic neoplasia / hydatidiform mole Dx
US: hydatidiform mole = snowstorm, clusters of grapes
excessive HCG
gestational trophoblastic neoplasia / hydatidiform mole Tx
evacuation- D&C dilation & curettage monitor HCG until zero -weekly until zero x 4 wks -monthly x 1 yr OCP (prevent preg b/c recurrence x 1 yr)
gestational trophoblastic neoplasia / hydatidiform mole complications & Tx
invasive mole: HCG doesn’t drop
-Tx methotrexate
choriocarcinoma
-Tx methotrexate (chemo), XRT, monitor HCG
RF for choriocarcinoma
molar preg!!
abortion, ectopic
chronic vs. gestational HTN
20 wks
RF for hydatidiform mole
chronic HTN <20 wks/before preg
chronic HTN BP mild, severe
mild >140/90
severe >180/100
mild preeclampsia
HTN + proteinuria >20 wks
>140/90
proteinuria >0.3 g x 24hr urine
severe preeclampsia
>160 (180)/110 proteinuria >5 g x 24hr urine, 3+ protein dip x 2 oliguria <500 mL x 24 hrs cerebral visual disturbance (HA, scotomata) RUQ pain (hep hemorrhage) pulm edema hepatic dysfn thrombocytopenia IUGR
delivery guidelines in severe preeclampsia
delivery regardless of gest age
RF for (pre)eclampsia
**nulliparity
multi fetal gestation, >35 y/o, chronic HTN, nephropathy, obesity, AA, DM, Hx of preeclampsi
eclampsia
severe preeclampsia + grand mal seizure
fetus can withstand 20 min seizure: fetal hypoxia
Sx preeclampsia
**puffy face, edema doesn’t resolve with elevation, HTN
RUQ tender, hyperreflexia, ankle clonus
labs preeclampsia
incr Hct, thrombocytopenia, incr PT/PTT, decr renal function, proteinuria, hepatic dysfn
BP goal pregnancy- in chronic HTN
150-160 / 110-110
Tx chronic HTN in pregnancy
methyldopa, labetalol, nifedipine, hydralazine
CAN continue diuretics if on them
Tx mild preeclampsia
MONITOR
non-stress test 2x/wk, US q 3 wks, fetal movement daily
Tx severe preeclampsia
*hydralazine (HTN)
*Mg sulfate 4-6 mg/dL IV (seizure prophylaxis)
labor induction- C section
postdelivery- 24 hrs on Mg sulfate
(not diazepam, phenytoin)
Mg sulfate reversal agent
10% Ca gluconate IV
HELLP syndr
hemolysis, elev liver enzymes, low plts
sometimes with severe preeclampsia/eclampsia
HELLP Sx
high BP, vague Sx malaise, RUQ pain
HELLP complications
fetal mortality, hepatic rupture, ARF, pulmonary edema, postpartum hemorrhage, DIC
Tx HELLP
plt transfusion (if <500)
RBC
FFP
when to Tx anemia in pregnancy
Hg < 10-11
folate supplemetation.
0.4 mg/day
Fe def anemia supplement
PNV + Fe 60-120 mg/day + vit C
gestational diabetes complications
spontaneous abortion, macrosomia (big), polyhydramnios
gestational diabetes testing when, what
24-28 wks
glucose intolerance test: 1 hr glucose challenge (no fast)
if >140 then GTT
Tx gestational diabetes
1st line: diet, nutrition
- monitor
- combo NPH/regular (immed, fast)
- glyburide
NOT metformin after 1st trimester
DM 1 in pregnancy complications
hypoglycemia, DKA, preeclampsia, ESRD (diabetic nephropathy), retinopathy
postpartum thyroiditis def
painless hyperthyroid–> hypothyroid in 1 yr postpartum
existing hypothyroidism in preg- mgmt
monitor levels once per trimester
Tx UTI in preg
macrobid (not after 38 wks)
keflex
ceftin
NOT bactrim! (C)
Tx pyelonephritis in preg
ceftriaxone (rocephin)
unasyn, ampicillin, gentamicin
Tx asthma in preg
ICS (budesonide) + rescue (albuterol)
Tx appendicitis in preg
open or laparoscopic ectomy
Tx cholelithiasis in preg
asymptomatic: conservative
symptomatic: open or laparoscopic ectomy
Tx trauma in preg
fetal monitor
minor: 2-6 hrs
major: min 24 hrs
TORCH
toxoplasmosis other: syphilis, parvovirus, varicella, mumps, HIV Rubella CMV Herpes
Toxoplasmosis mom Tx
spiramycin (prevent transmission)
fetal complications Toxoplasmosis
mental retardation, chorioretinitis
blind, epilepsy, hydrocephalus, intracranial calcifications
congenital syphilis syndr
MP rash, snuffles, hepatosplenomegaly, jaundice, chorioretinitis, LAN, Hutchinsons teeth
chorioretinitis assoc with
toxoplasmosis, syphilis, varicella
posterior uveitis
parvovirus complications
spontaneous abortion, hydrops fetalis (fluid overload)
treponema pallidum
syphilis
varicella complications
skin scar, limb hypoplasia, chorioretinitis, microcephaly
can you give varicella vaccine in preg?
no. live
HIV Tx
antiretroviral therapy
C section at 38 wks
no breastfeeding
breastfeeding if HIV?
no
rubella testing when?
1st prenatal visit
german measles
rubella
rubella complications
mental retardation, deaf, cataracts, congenital heart dz, PDA
can you give rubella vaccine in preg?
no. live
CMV screening and Tx
none. no routine screening b/c rare
CMV complications
hydrops fetalis, IUGR
genital herpes Tx when, what
acyclovir, 36 wks
herpes delivery policy
no active infection: vaginal
active: C section
Hep B breastfeeding policy
transmitted through breastmilk
can breastfeed if chronic carrier + infant vaccinated/HBIG
Hep B Tx mom, infant
mom: HBIG + vaccine immediately
infant: in 12 hrs birth
Hep B infectious
HBeAg
Hep B acute infection
HBsAg
Hep B transmission
high if contracted in 3rd trimester
Hep C transmission
lower
high if viral load high
GC ophtalmia infant Tx
emycin or tetracycline eye ointment
chlamydia presentation infants
conjunctivitis birth, 1-2 mo pneumonia
chlamydia Tx mom
ceftriaxone
1 g azithromycin
hydrops fetalis assoc is
parvovirus, CMV
IUGR
< 10th %
SGA
lower extreme of normal
IUGR complications
death, asphyxia
acidemia, seizures, sepsis, resp distress, meconium aspiration, low apgar
RF for IUGR
mom medical dz, smoking, substance abuse, malnutrition, placental dz, multiple gestation, infection, genetic disorder, teratogen
IUGR Tx
fetal monitoring
amniotic fluid vol (oligohydramnios)
amniocentesis (FLM)
macrosomia
> 90th %
8.8-9.9 lb
4000-4500 g
RF for macrosomia
DIABETES, Hx macrosomia, preg wt gain, male, genetics
placenta previa def, Sx
close/over os
PAINLESS BLEEDING, spotting stops in 2 hrs
>30 wks gestation
RF placenta previa
EXPERIENCED MOMS
Hx, C section, uterine surgery, multiparity, advanced age, cocaine, smoking
Tx placenta previa
bed rest, fluids
C section usually
complications placenta previa
placenta acreida (abnorm adherence)
fetal anomalies
preterm
placental abruption def, Sx
premature separation from uterine wall
PAINFUL BLEEDING, continuous, increased
RF placental abruption
HTN, preeclampsia, infection, trauma
+same as placenta previa
Tx placental abruption
C section
uterine rupture Px
bad. 75% mom mortality. fetal mortality
preterm labor
<37 wks
complications of preterm delivery
RESP DISTRESS, intraventricular hemorrhage, enterocolitis, sepsis, neuro impairment, seizure, cerbral palsy
MCC preterm
mult gestations
PROM, Hx, cervical insuff, infection, uterine enlargement, smoking
how to predict preterm
fetal fibronectin (present if near delivery) transvag US (cervical length) cervix dilation/effacement bacterial vaginosis (predisposes to preterm)
Tx preterm labor
tocolytic agents- anti contraction (Mg sulfate!!!!), corticosteroids (for FLM)
MC complication of PROM
intrauterine infection
Dx PROM
gush/steady leakage
nitrazine: alkaline 7.1-7.3
fern test
US: vol amniotic fluid
*sterile speculum exams! no digital exams!
Tx PROM >37 wks, 28-37 wks
> 37 wks: delivery
32-33 wks: corticosteroids (FLM), abx
24-31 wks: corticosteroids, abx, tocolytics
<24 wks: delivery (not enough amniotic fluid)
28-37 wks: labor in 24 hrs-1wk, amniocentesis (FLM), corticosteroids (FLM)
goal of preg length
33 wks
MCC postterm pregnancy
incorrect est of gestational age
obesity, nulliparity
postterm complications
birth trauma, labor dysfn
macrosomia, shoulder dystocia, meconium aspiration, oligohydramnios
result of isoimmunization (Rh D)
fetal anemia, jaundice, kernicterus
Tx isoimmunization
rhogam anti-D = at 28 wks, and within 72 hrs delivery, and if bleeding/trauma
1 Rhogam dose protects?
30 mL fetal blood
isoimmunization test
Kleihauer-Betke test
MC complication mult gestations
preterm L&D
polyhydramnios, preeclampsia!!!, spontaneous abortion
adding each baby = decr gest age by
3-4 wks
twin-twin transfusion syndr def, Tx
monochorionic
Tx: intrauterine laser Tx (helps both)
death of one fetus Tx
none. damage done by the time of discovery (HOTN). no benefit to early delivery