Pregnancy Complications Flashcards

1
Q

How GDM is screened?

A

1-hr (50g) oral glucose tolerance test (OGTT)

  • If Negative (<130-140 mg/dL) → Routine prenatal care
  • If Positive (≥ 130-140 mg/dL) → 3-hr (100 g) OGTT
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2
Q

How is GDM diagnosed?

A

3-hr (100 g) OGTT

  • Negative
  • Positive for GDM
    • Two or more values are met or exceeded:
      • Fasting – 95 mg/dL
      • 1-hr – 180 mg/dL
      • 2-hr – 155 mg/dL
      • 3-hr – 140 mg/dL
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3
Q

What is the Non-stress test?

A
  • Non-invasive, patient goes to provider’s office, often biweekly)
  • External fetal monitor placed on abdomen, expect to see two 15x15 accelerations in 20 minutes if greater than 32 weeks EGA; predictive of fetal well-being for 3-4 days
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4
Q

What does a reactive non-stress test indicate?

A

A reactive non-stress test result indicates that the fetus’s heart rate increased normally in response to movement or contractions.

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5
Q

What does a non-reactive non-stress test indicate?

A

A non-reactive result means the heart rate didn’t increase enough.

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6
Q

What is a Biophysical profile (BPP)?

A
  • evaluates the well-being of a fetus, particularly in high-risk pregnancies
  • non-invasive
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7
Q

What are the five components assessed during a Biophysical profile?

A

Scored from 0-10, with lower score being more indicative of issues/need to deliver:

Fetal breathing
Fetal tone (extension/flexion of limb, opening/closing fist)
Fetal movement
AFI (amniotic fluid index)
Reactive non-stress test

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8
Q

What is the etiology of gestational diabetes (GDM)?

A
  • Glucose crosses placenta, insulin does not
  • Placental hormones increase
    insulin resistance
  • insulin requirements increase between 26-34 weeks gestation
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9
Q

What is GDM associated with?

A
  • Polyhydramnios
  • Increased rate of fetal death
  • Macrosomic infant (>4000gms)
  • Prematurity, RDS, hypoglycemia, polycythemia in the newborn
  • Congenital heart defects
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10
Q

How is GDM managed?

A
  • Universal screening between 24-28 weeks
  • Early screening if pt has risk factors:
    • history of GDM with prior pregnancy
    • strong family history of diabetes
      -obese
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11
Q

How is chronic hypertension characterized in pregnancy?

A
  • The presence of hypertension prior to pregnancy
  • Diagnosis of development of hypertension before 20 weeks
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12
Q

How is GDM managed?

A
  • Universal screening between 24-28 weeks
  • Early screening if pt has risk factors:
    • history of GDM with prior pregnancy
    • strong family history of diabetes
    • obese
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13
Q

How is gestational hypertension characterized in pregnancy?

A
  • Development of hypertension after 20 weeks gestation
  • Absent criteria for preeclampsia
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14
Q

What is the diagnostic criteria for gestational hypertension?

A
  • SBP ≥ 140 or DBP ≥ 90, or both measured on 2 different occasions at least 4 hours apart after 20 weeks gestation
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15
Q

How is preeclampsia characterized in pregnancy?

A
  • New onset hypertension which occurs most often after 20 weeks
  • Often accompanied by new onset of
    proteinuria
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16
Q

What is the diagnostic criteria for preeclampsia?

A

BP > 140 systolic or > 90 diastolic on 2 different occasions 4 hours apart
PLUS
Proteinuria
- >300mg in a 24-hour urine collection
- >0.3 value on a protein/creatinine (P/C) ratio

OR

BP >140 systolic or >90 diastolic
PLUS
ONE severe symptom
- Severe headache (unrelieved with tylenol, rest, etc.) with or without
vision changes
- Epigastric (abdominal pain)
- Chest pain
- Pulmonary edema
- Abnormal LFTs (liver function tests)

17
Q

How is eclampsia characterized in pregnancy?

A
  • New onset of tonic-clonic or focal seizures in the absence of other causative conditions
  • Significant cause of maternal death
18
Q

How is chronic hypertension with superimposed preeclampsia characterized in pregnancy?

A
  • Preeclampsia is diagnosed in a pregnant person with known hypertension
    • New onset of proteinuria
    • Elevated liver function/enzymes
    • Thrombocytopenia
    • Neurologic symptoms
  • Highest rate of maternal and fetal/neonatal complications
19
Q

How is HELLP syndrome characterized?

A

Hemolysis (H)
- Rapid breakdown of RBCs
Eevated Liver Enzymes (EL)
- Liver transaminases are at least 2x
normal levels
- RUQ pain
- LDH >660
Low Platelets (LP)
- Platelets <100,000
(remember 150k is still the lower end of normal)

20
Q

What can HELLP syndrome lead to?

A
  • End organ damage and DIC
    (disseminated intravascular coagulation)
  • Rupture of liver capsule
21
Q

How to ensure thorough assessment for hypertension in pregnancy?

A
  • Accurate blood pressure (manual cuff preferred)
  • Reflexes and clonus (preeclampsia disrupts communication between
    cerebral cortex and spinal cord)
  • Edema
  • Neurological assessment
  • Intake/output
22
Q

How to get proper fetal surveillance?

A
  • Kick counts
  • NSTs
  • BPPs
23
Q

What labs are important for hypertension in pregnancy?

A
  • CBC
  • AST/ALT
  • creatinine
  • coagulation
  • uric acid
  • LDH
  • urine
  • protein/creatinine ratio
24
Q

What medications are used for hypertension in pregnancy?

A
  • Severe HTN: labetalol, hydralazine IV
  • Magnesium sulfate for seizure prevention (not effective at lowering BP)
25
Q

Describe magnesium toxicity values.

A
  • Therapeutic range : 5-8mg/dL
  • Loss of DTRs: 9-12mg/dL
  • Respiratory depression: 12-15mg/dl
  • Cardiac arrest : >15mg/dl
26
Q

What is the antidote for magnesium toxicity?

A

calcium gluconate

27
Q

What is Vasa previa?

A

cord vessels implanted in fetal membranes and cross or are near the cervix

28
Q

What is placenta previa and how is it diagnosed?

A
  • Placenta covers cervix and results in bleeding
    • painless, bright red vaginal bleeding
  • Diagnosed via ultrasound
29
Q

What are risk factors of placenta previa?

A
  • previous cesarean delivery or uterine surgery
  • advanced maternal age
  • tobacco use
  • multiple gestation
  • multiparity
30
Q

How to manage placenta previa?

A
  • bed rest
  • fetal surveillance
  • pelvic rest
  • patient education
  • no cervical exams
  • hospitalization (multiple bleeding episodes)
  • c/s if doesn’t resolve
31
Q

What are different types of Invasive Placenta?

A
  • accreta
  • increta
  • percreta
32
Q

What is Placenta accreta?

A

chorionic villi invade beyond uterine lining and decidua basilis

33
Q

What is Placenta increta?

A

chorionic villi invade into the myometrium

34
Q

What is Placenta percreta?

A

chorionic villi go past the myometrium, can attach to other
organs such as bowel or bladder

35
Q

What can invasive placenta lead to?

A

Significant risk of hemorrhage and need for hysterectomy

36
Q

What is placenta abruption?

A

Placenta separates from uterine lining prior to delivery of fetus

37
Q

What are signs and symptoms of placenta abruption?

A
  • dark red vaginal bleeding
  • abdominal pain
  • rigid abdomen
  • uterine contractions and tenderness
  • elevated uterine resting tone
  • non-reassuring fetal heart rate pattern
38
Q

What are risk factors for placenta abruption?

A
  • multiparity
  • history of abruption,
  • hypertension
  • advanced maternal age
  • premature rupture of membranes (PROM)
  • cocaine use
  • tobacco use
  • polydramnios