Pregnancy Associated Disorders Flashcards
Intrauterine growth restriction (IUGR)
lower than normal fetal growth characterized by an estimated fetal weight below the 10th percentile for a given gestational age.
two types of IUGR: asymmetrical and symmetrical
asymmetrical IUGR
- caused by extrinsic factors which affect the fetus in the later stages of gestation (i.e. 3rd)
- most common manifestation of IUGR (∼ 70%), has a late onset,
- usually due to maternal systemic disease (e.g., hypertension) that results in placental insufficiency
symemetrical IUGR
- Caused by intrinsic factors which affect the fetus in the early stages of gestation.
- less common (∼ 30%)
- usually due to a genetic disorder (e.g., aneuploidy), congenital heart disease, or early intrauterine TORCH infection that affects the fetus early in gestation.
Maternal Etiologies of IUGR
- Substance use (e.g., alcohol, cigarettes, cocaine, heroin)
- Teratogenic drugs: ACE inhibitors, carbamazepine, phenytoin, warfarin
- Systemic diseases resulting in placental insufficiency
Uteroplacental causes of IUGR
- Placental insufficiency
- Placenta Previa
- Multiple Gestations
- placental abruption
- Umbilical artery thrombosis/ extensive infarction
- Uterine malformations (fibroids)
Placental insufficiency
A disorder of the fetomaternal circulation that causes inadequate blood flow to the placenta and impaired substance exchange (e.g., oxygen) between the mother and fetus, leading to metabolic compromise of the fetus.
Risk factors for placental insufficiency
smoking; diabetes mellitus; chronic hypertension; anemia; SLE;
Pregnancy-related conditions (preeclampsia, Rh incompatibility)
Fetal factors for IUGR
- Genetic abnormalities in the fetus (e.g., aneuploidy)
- Cyanotic congenital heart defects
- Early intrauterine infections (TORCH)
Pathophysiology of asymmetric IUGR
- insufficient transplacental delivery of oxygen and nutrients to the fetus and impaired return of carbon dioxide and fetal metabolic waste products from the fetus to the mother’s circulation
- Fetal hypoxia and hypoglycemia → shunting of blood flow to vital fetal organs (brain, heart, and adrenal glands) bypassing other organs (e.g., liver, muscle, fat tissue)
Fetal signs of IGUR
- Small for gestational age (or with a birth weight below 10th percentile)
- Decreased or absent fetal movements
- Asymmetrical IUGR: disproportionate growth restriction
- head are normal while the body and limbs are thin and small
- Symmetrical IUGR: global growth restriction
- circumference of the head is proportional
IGUR Diagnostics
- Serial ultrasonography
- Decreased fetal growth; fetal weight below the 10th percentile
- Oligohydramnios
- Doppler velocimetry of umbilical artery: reduced or reversed diastolic flow
- Nonstress test: late decelerations of the fetal heartbeat
- Biophysical profile
Biophysical Profile in IUGR
- Oligohydramnios; AFI < 5 (N=8-18)
- Absent fetal breathing movements
- Decreased fetal movement and tone
- A score ≤ 4 indicates fetal hypoxia and/or placental insufficiency.; labor should be induced.
Tx IGUR
- Treatment of the underlying condition
- Close monitoring; (NST, CST, BPP)
- If the infant is close to term, administer steroids and induce labor after 48 hours.
- If there are signs of nonreassuring fetal status; induce labor or perform immediate cesarean delivery.
IUGR Complications
- stillbirth
- preterm labor
Hypertensive Preganancy Disorders
- Gestational hypertension (most common, least severe)
- Chronic Hypertension
- Preeclampia
- Superimposed preeclampsia
- HELLP syndrome
- Eclampsia
Gestational hypertension
- pregnancy-induced hypertension with onset after 20 weeks gestation
- Defined as a systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg on 2 separate measurements at least 4 hours apart
- can only be diagnosed if the patient was normotensive prior to 20 weeks gestation
Chronic hypertension
hypertension diagnosed < 20 wks gestation or before pregnancy
Preeclampsia
- gestational hypertension with proteinuria, renal insufficiency, thrombocytopenia, evidence or liver damage, pulmonary edema, and or cerebral edemas
- Superimposed: preeclamsia that occurs in a patient with chronic hypertension
- HELLP syndrome: a life threatening form of preeclampsia
HELLP
H= hemolysis
EL= elevated liver enzymes
LP= low platelets
Eclampsia
severe form of preeclampia with convultive seizures and/ or coma
Risk factors for hypertensive preganancy disorders
- Age < 20 or > 40 years
- African-American race
- Diabetes mellitus or gestational diabetes
- Chronic hypertension
- Chronic renal disease (e.g., SLE)
Pregnancy-related risk factors
- Nulliparity
- Previous preeclampsia
- Multiple gestation (twins)
- Hydatidiform moles
Clinical Features: Gestational hypertension
- Asymptomatic hypertension
- Nonspecific symptoms (e.g., morning headaches, fatigue, dizziness)
clinical features: preeclampsia
without severe features
- Usually asymptomatic
- Nonspecific symptoms may include:
- Headaches
- Visual disturbances
- RUQ or epigastric pain
- Rapid development of edema
- Hypertension
- Proteinuria
clinical features: preeclampia
with severe features
- Severe hypertension (systolic ≥ 160 or diastolic BP ≥ 110)
- Proteinuria, oliguria
- Headache
- Visual disturbances (e.g., blurred vision
- RUQ or epigastric pain
- Pulmonary edema
- altered mental state
Clinical features: HELLP syndrome
- Onset: most commonly > 27 weeks gestation (30% occur postpartum)
- Preeclampsia
- RUQ pain (liver capsule pain; liver hematoma)
- Rapid clinical deterioration (DIC, pulmonary edema, acute renal failure, stroke, abruptio placentae)
Clinical features Eclampsia
- Onset: the majority of cases occur in the intrapartum and postpartum period
- Eclamptic seizures: generalized tonic-clonic seizures
- Deterioration with headaches, RUQ pain, hyperreflexia, and visual changes are warning signs of a potential eclamptic seizure
Initial work up for Pregnancy hypertensive disorders
- blood pressure must be elevated on at least 2 occasions that are at least 4 hours apart
- Urine tests to determine proteinuria
- 24-hour urine collection (gold standard): ≥ 300 mg/24 h
- Urine dipstick: 1–2 + protein
- Laboratory analysis
- CBC
- Kidney function tests
- HELLP syndrome is suspected:
- Peripheral smear (assess for hemolysis)
- coagulation studies are indicated if (i.e., thrombocytopenia and/or liver function)
Diagnostic criteria for preeclampsia without severe features
- Hypertension (> 140/90 mmHg)
- Proteinuria ≥ 300 mg/24 h
- If proteinuria is absent, at least one of the following must be present:
- Thrombocytopenia
- Impaired renal function
- Impaired liver function
- Visual or neurologic changes
- Pulmonary edema
Diagnostic criteris for preeclampsia with severe features
one or more
- Severe hypertension (> 160 mmHg systolic or > 110 mmHg diastolic)
- Thrombocytopenia < 100,000/μL
- Impaired renal function (serum creatinine > 1.1 mg/dL or doubling of serum creatinine)
- Impaired liver function (elevated transaminases)
- Pulmonary edema
- Cerebral or visual symptoms
Diagnotic criteria for eclampsia
Primarily a clinical diagnosis: patient with preeclampsia presenting with new-onset grand mal seizures
Differential of eclampsia
- Epilepsy
- Encephalitis
- Metabolic disorders (e.g., hypoglycemia, hyponatremia)
- Hemorrhagic stroke
- Ischemic stroke
- Withdrawal syndromes
Differntial of HELLP syndorme
- Throboticmicroangiopathy (TTP, HUS)
- Fulminant VIral Hepatitis
- Acute Fatty liver of preganancy
- itrahepatic cholestatis of pregnancy
Acute Fatty Liver of Pregnancy
- a rare disease most common in the third trimester characterized by extensive fatty infiltration of the liver, which can result in acute liver failure
- Pathophysiology: dysfunction of fatty acid β-oxidation
Symptoms of acute fatty liver of pregnancy
- Sudden onset of jaundice
- RUQ pain, nausea, and vomiting
- Coagulopathy
- Hypoalbuminemia; ascites
Complications of acute fatty liver of pregnancy
- Acute liver failure
- Acute renal failure
- Encephalopathy
acute fatty liver of preganancy
diagnostics
Laboratory analysis:
- ↑ AST, ↑ALT
- ↑ WBC, ↓ platelets
- Hypoglycemia
- Liver synthesis parameters: ↓↓ clotting factors , ↓↓ Cholinesterase
Imaging: rule out other diagnoses
acute fatty liver of pregnancy Tx
Therapy: immediate Cesarean (C)-section
intrahepatic cholestatis of preganancy
rare disease most common in the third trimester that presents with pruritus, jaundice, and an elevation in serum bile acid concentrations
intrahepatic cholestatis of pregnansy
symptoms
jaundice
pruritis
intrahepatic cholestatis of pregnancy
complications
Fetal growth restriction
fetal mortality
Premature labor; preterm birth
Recurrence in following pregnancies
intrahepatic cholestatis of pregnancy
diagnostics
- ↑ Total serum bile acid levels (cholic acid and chenodeoxycholic acid) > 10 micromol/L
- ↑ ALP
- ↑ ALT, AST
- ↑ direct bilirubin
- Hepatitis serology (to rule out viral hepatitis)
intrahepatic cholestatis of pregnancy
tx and prognosis
Therapy
- First-line medication: ursodeoxycholic acid PO
- An early therapy with ursodeoxycholic acid reduces the risk of preterm birth and stillbirth.
Prognosis: fully reversible postpartum
gestational hypertension and preeclampsia w/o severe features
treatment
- antepartum evaluation (Ultrasound, NST, BPP)
Hospitalization and deilvery if:
- greater than or 37 0/7 wks
- suspected placental abption
- Labor or rupture of membranes
- Fetal weight < 5th percentile
- Oligohydramnios
- Abnormal maternal or fetal test results
if not outpatient with antihypertensives: labetalol, hydralazine, nifedipine
preeclampsia with severe features
treatment
DELIVERY if
- Pregnancy is ≥ 34 0/7 weeks gestation
- Pregnancy is < 34 0/7 weeks gestation with maternal or fetal instability
- Immediate delivery after stabilization (IV magnesium sulfate prophylaxis, antihypertensive drugs, corticosteroids )
If mom is stable:
- monitor in patient
- treat severe hypertension
- magnesium sulfate
- corticosteroids
eclampsia treatment
Stabilization
-
Magnesium sulfate IV (first-line)
- Antidote: calcium gluconate IV if early signs of magnesium toxicity (decreased deep tendon reflexes)
- Position patient on left lateral decubitus position → prevent placental hypoperfusion through compression of the inferior vena cava
Delivery: once the mother is stable and seizures have stopped
HELLP syndrome treatment
Stabilization
- Blood transfusions
- Antihypertensive agents (labetalol, hydralazine)
- Magnesium sulfate
Delivery: if ≥ 34 weeks gestation or at any gestational age with deteriorating maternal or fetal status
Maternal complications of hypertensive pregnancy disorders
- Placental abruption
- Cerebral hemorrhage, stroke
- DIC
- Acute respiratory distress syndrome (ARDS)
- Maternal death
ARDS and cerebral hemorrhage are the most common causes of death.
fetal complications of hypertensive pregnancy disorders
- Fetal growth restriction
- Preterm birth
- Seizure-induced fetal hypoxia
- Fetal death
Prevention preeclampsia
Prophylactic low-dose ASA PO from 12–14 weeks gestation for patients with a high risk
Nausea and comiting of pregancy
Risk factors
- Nulliparity
Clinical features
- Nausea and/or vomiting
- Normal vital signs, lab findings, and normal physical examination
nausea and vomiting of pregnancy
Tx
- Rehydration
- Nonpharmacologic options
- Adapt diet and avoid triggers.
- Ginger tea/capsules
- Antiemetic (add in a stepwise manner)
- Pyridoxine (vitamin B6) and/or doxylamine
- For refractory symptoms, add one of the following:
- Diphenhydramine
- Dimenhydrinate
- Last resort; methylprednisolone
Hyperemesis gravidarum
severe, persistent nausea and vomiting associated with a > 5% loss of pre-pregnancy weight and ketonuria
hyperemesis gravidum clinical features
- nausea, vomiting,
- physical signs of dehydration,
- hypersalivation,
- orthostatic hypotension,
- malnourishment
Hyperemesis gravidarum
Tx
- Antiemetic therapy:
- May require glucocorticoid therapy
- IV fluid resuscitation/replacement
- Electrolyte and thiamine repletion
Cervical insufficiency
- painless cervical dilation, in the absence of uterine contractions;
- second trimester of pregnancy
Clinical features
- Painless cervical dilation with or without prolapsed membranes
cervical insufficiency
diagnosis
- Clinical diagnosis typically before 24 weeks’ (may be up to 28 weeks’) gestation
- history of ≥ 2 previous mid-trimester pregnancy losses
- history ≥ 3 preterm births not explained by any other cause
- transvaginal ultrasound cervical length < 25 mm before 24 weeks’ gestation
- A shortened cervical length alone is not sufficient to diagnose must have history.
cervical insufficiency
Tx
- Serial cervical ultrasound monitoring should be commenced in high-risk women (i.e., previous preterm birth) between 16–24 weeks’ gestation.
- Cervical cerclage
- Progesterone supplementation (vaginal or intramuscular): indicated for a short cervical length at < 24 weeks’ gestation
cervical cerclage
- Definition: placement of a supportive suture in the cervicovaginal junction to prevent early pregnancy loss or preterm birth
- Indications: only in singleton pregnancies
Supine hypotensive syndrome
Compression of the vena cava and pelvic veins by the uterus may occur during the third trimester of pregnancy as a result of the mother lying in a supine position.
peripheral edema in pregnancy
- Very common, benign finding
Management
- Rule out DVT and preeclampsia
- Monitoring; usually no treatment necessary
MSK pain in pregnancy
- Lower back pain: increased lumbar lordosis caused by relaxation of the ligaments supporting the joints of the pelvic girdle in preparation for childbirth
- Carpal tunnel syndrome (caused by peripheral edema; usually resolves after delivery)