Pregnancy And Pre Natal Diagnosis Flashcards
hCG functions
Stimulates
-corpus luteum to make progesterone during the first week of pregnancy
-Steroid synthesis by placenta-fetus unit
-Promotes gonads development
Serum hCG exceeds 5IU/ml in?
6-12 days after fertilization
Synthesis of beta unit of hCG peaks at about
8-10 weeks
alpha unit continues to increase throughout the pregnancy
Secretion of placenta lactogen near term is
1-2 g/day
It increases during pregnancy
AFP is peaks at what week
12-14 week
AFP peaks at what volume, decreases to what volume at term and after 1 year what’s it volume
It PEAKS at 12-14th WEEK at 3mg/mL,
DECREASES at TERM at 20ug/mL
After 1 YEAR, it reaches 1ng/ml
Types of hCG
-unmodified hCG
-free hCG
-nicked hCG
Using ultrasonography a developing embryo can first be visualized at about what week?
About 6 weeks of gestation
Recognition of major internal organs and extremities using Ultrasonography to determine if any are abnormal can best be seen at what week?
16-20 weeks of gestation
Amniotic fluid required for amniocentesis starts to be present at what week?
14-20 weeks
Amniocentesis can be analyzed for fetal lung maturity at what weeks?
35-36 weeks of gestation
What are checked for lung maturation?
-Lecithin : sphingomyelin ratio
-Phosphatidyl glycerol
Chorionic Villus Sampling can be safely performed between what weeks?
9.5-12.5 weeks
What test is used to quantify the amount of fetal blood cells in the maternal circulation …
If it’s positive it’s suggests?
Kleihauer-Betke test
Positive for fetal-maternal hemorrhage
The sequencing of maternal plasma cell-free DNA can detect?
Fetal autosomal aneuploidy
