Pregnancy Flashcards
What CV changes are made during pregnancy?
Heart adapts to the increased demands via enlarging the uterus and foetus
How much does the resting HR increase by?
25%
How much does the HR increase at each trimester?
5-10 bpm first trimester
15 bpm second and third trimester
What happens in the 2nd and 3rd trimester
- increased oestrogen and chronic gonadotropin stimulates the HR increase
- SNS activation sedentary to maintain BP
how much does Oestrogen and progesterone decrease peripheral vascular
20%, and thus must increase to maintain BP
How much does SV increase?
25%
Why does the increase in blood volume occur?
progesterone increase production if Renin –> sodium reabsorbed –> kidneys reabsorb fluid to the plasma volume
Why is there a LV size increase due to maternal hormones?
- Oestrogen stimulates the myocardial hypertrophy, increasing contractility
- increase blood volume stimulates some myocardial hypertrophy
- growth is eccentric vs. concentric
What is the percentage the SV increase by in the 1st trimester?
10%
What percentage does blood volume increase in?
35-50%
what is the offset of BP?
increased volume offset by an increase in venous capacitance = blood pressure is not increased
What does the offset of BP cause
problems with postural hypertension
What helps to prevent hyperthermia during exercise?
increase in vasodilation at the skin which increases heat loss
Why can pregnant women become anaemic?
> increase in plasma volume vs red blood cells (increases 20%)
What is the Hb in pre-pregnancy and in the 3rd trimester
150g. L-1
120g. L-1
Why may blood clotting increase
relaxation of the blood vessel walls with hormonal changes (to keep BP normal after increase in blood volume) from the pressure of the uterus of the interior vena cava
Why may pregnant women develop varicose veins?
exercise assists the blood flow in the legs and feet and helps prevent or minimise these problems
What are the pulmonary adaptations when pregnant?
- elevation of the diaphragm
- uterine enlargement elevated the diaphragm up to 4cm
How much does this reduce reserve volume
25%
why does the rib cage flair outwards?
as it reduces the filling effectiveness
Why is the work of breathing increase at rate and during exercise?
due to the diaphragm resistance
What happens to the respiratory physiological when one is pregnant?
- reduction in total lung capacity occurs
- inspirational capacity remains the same
- reserve volume gets squeezed as a consequence
What does an increased plasma progesterone mean?
stimulate respiratory centre to be more sensitive to CO2
What occurs with hyperventilation?
–> resting hypocapnia (decrease PCO2) –> maternal alkalosis and increased PO2
What does the maternal alkalosis do?
protect against foetal acidosis
when does increase in performance in endurance activities occur?
first 12-15week, before the increase in BW and uterine size reduces or stops involvement in competitive athletics
What does the increase in performance result from
increased blood volume and RBC mass
After the 2nd trimester what happens to the PVO2
- increase O2 demand of foetus
- increase BM
How much does resting O2 increase by?
15-30%
What are the reasons behind this?
- enlarging uterus and growing foetus
- increased breathing rate
- Uterine contents are subtracted maternal increased by ~ 4%
Why is there an major increase in CHO usage?
foetal demands of glucose is large
Why is there an increase in maternal insulin productions
- increase oestrogen causes B-cells hyperplasia in the pancreas
What does increased insulin production cause?
hyperinsulinemia
what increases the fat deposition within the mother?
stimulation of lipogenesis
what percentage of women have gestational diabetes (GDM)
2-3%
what does human placental lactose do?
counters insulin effects
reduces CHO use by mother….
leaves more CHO for foetus
what does mum have to rely on more?
Body fat –> lipolysis –> resulting in reduced adiposity
what percentage of mums with GDM become type II diabetic post 4yrs delivery
60%
Why is there increased birth weight?
CHO foetus increases birth weight (mores fat)
What can cause birthing problems?
disproportionate growth of head and shoulders
If the baby has increased insulin production to counter mothers high glucose, what does this mean?
- insulin is the growth promoter
- baby at risk of low blood glucose post partum
What can maternal exercise help with?
lower blood glucose (less insulin required) and increase insulin sensitivity
What is the incidence rate of preeclampsia
3-7%
What preeclampsia associated with?
- hypertriglyceridemia
- insulin resistance
- SNS overactivity
- Atherosclerotic lesions in placenta
- increased leptin
- increases risk of becoming hypertensive (20% vs. 2%)
is it true that preeclampsia is reported in active women?
Yes
By what percentage?
35-70%
Why can exercise help preeclampsia?
- reduced levels of C-reactive PRO –> stops endothelium producing NO (nitric oxide) —> less vasodilation
What does an increase rate of NO production cause
vasodilation
What is the relationship between decreased leptin and hypertension?
leptin can contribute to hypertension because of its role of stimulating the body to burn fat
How can leptin lead to hypertension?
stimulates SNS to burn fat- but this increases BP and leads to hypertension
What can increase progesterone (smooth muscle relaxant) and increase uterine size lead to?
- constipation
- slowing of gastrointestinal motility
- relaxation of the lower oesophageal sphincter
what can the relaxation of the oesophageal sphincter lead to?
increased gastric reflex –> heartburn
what happens to the anterior displacement of enlarging uterus during pregnancy?
- change in CoG
- exaggerates normal lumber lordosis
What can the increase in hormone levels more so progesterone do?
- ligament and joint laxity
- pelvic area susceptible
What occurs when the breasts enlarge?
- CoG moves interiorly and anteriorly
- increased weight contributes to upper back and shoulder pain
What is diastatic recti?
separation of abdominal muscles from the midline point
why does diastatic recti occur?
enlarging uterus
What is the incidence rate for diastasis recti?
~20-90%
what is the average weight gain for a pregnant women?
~ 12kg
What elements does this weight gain full under and by how much?
- Fetus 3.5kg
- Uterus 1kg
- placenta 0.5kg
- Amniotic fluid 0.8kg
- breast enlargement 1.5kg
- maternal fluid gain 2.0kg
- maternal fat 2.5kg
what are the effect on the foetus during acute exercise?
placental blood flow
How can the uteroplacental blood flow change with exercise?
flow to the placenta remains unchanged, but flow of blood in the uterus is reduced
Why might foetal O2 supply not be changed or slightly reduced?
increased placental a-vo2 difference –> where the baby extracts more
How quickly does the effects of acute exercise on a pregnant women return back to baseline?
20 minutes
What does Foetal Tachycardia at >160bpm mean?
The foetal HR increases when the mum is exercises, and circulating maternal catecholamines during exercise
What other effect can foetal tachycardia have?
increase maternal core temperature
What is the HR for the classification of foetal bradycardia
<120bpm
when in foetal bradycardia, what is the response to hypoxia?
reduce foetal O2 demands
When is hypoxia and foetal bradycardia seen?
in long duration exercise and post exercise