PREDICT Trial Flashcards
Year original results were published?
2010
Number of centers in PREDICT trial?
39
What was the PREDICT study objective (original publication)?
Validate gene expression testing for assessment of obstructive CAD
Number of patients studied? Total? In validation set?
1160 (in follow up) 526 in validation set
Principal Investigator?
Eric Topol, MD; Scripps Research Institute
Description of patients enrolled?
Stable patients with symptoms or non-symptomatic and high risk.
Non-diabetic
No known CAD, prior MI, or revasculariztion
No known inflammatory disorders, elevation in WBC, cardiac protein markers
When did the patient get Corus CAD test?
At “elective” angiography
Overall percentage of patients with obstructive CAD?
37% (prevalence)
What was the percentage of obstructive CAD in women studied?
26%
Name of study demonstrating percentage of findings in elective cardiac catheterization?
Low Diagnostic Yield of Elective Coronary Angiography; NEJM 2010; Patel, et al.
Corus CAD sensitivity in PREDICT?
85%
Corus CAD NPV in PREDICT?
83%
Corus CAD Positive predictive value in PREDICT?
46%
Corus CAD test specificity?
43%
When was the gender-specific analysis published?
2012
What was the prevalence of obstructive CAD in men?
47%
What was the percentage of men and women with NO CAD?
18% of Men and 38% of women had no CAD
In study: indicator of obstructive CAD in Women?
Corus CAD
Indicator for obstructive CAD in Men?
Corus CAD, Typical Chest Pain, Age, Dyslipidemia
Role of MPI was significant?
Not significant indicator in Men or Women
Objective of 12 month PREDICT 12 month follow-up?
To evaluate if patients with a low CAD score have significant risk of Major adverse events @ 12 months
What percentage of procedures and events occurred in first 30 days?
92% (267/292)
How many patients were evaluated in the 12 month follow-up?
1116 (96% of original 1160)
What is a “low” Corus CAD score in Predict?
Less than or equal to 15
What MACE rate does a low Corus score have in this cohort @ 12 mos?
Less than 1% (NOT associated with the index coronary angio)
What % of patients were revascularized within 12 months (including index coronary angiography) with a low CAD score?
9.1%
What is MACE defined as in this cohort?
Stroke, TIA, MI, or all-cause death
What is a “mid-range” CAD score in PREDICT?
16-27
What is a “high” CAD score in PREDICT?
28-40
What percentage of event rate and procedure rate was seen in the “high” CAD score group?
Nearly 40%
Three times that of the “low score” group.
Why a score of 15?
This corresponded to 20% likelihood of CAD.
What is “high probability of CAD in this study?
Framingham risk score of 20% (10 year likelihood of having event)
What journal was this published in?
Annals of Internal Medicine
