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CardioDX-Predict > PREDICT Trial > Flashcards

PREDICT Trial Flashcards

1
Q

Year original results were published?

A

2010

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2
Q

Number of centers in PREDICT trial?

A

39

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3
Q

What was the PREDICT study objective (original publication)?

A

Validate gene expression testing for assessment of obstructive CAD

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4
Q

Number of patients studied? Total? In validation set?

A

1160 (in follow up) 526 in validation set

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5
Q

Principal Investigator?

A

Eric Topol, MD; Scripps Research Institute

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6
Q

Description of patients enrolled?

A

Stable patients with symptoms or non-symptomatic and high risk.
Non-diabetic
No known CAD, prior MI, or revasculariztion
No known inflammatory disorders, elevation in WBC, cardiac protein markers

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7
Q

When did the patient get Corus CAD test?

A

At “elective” angiography

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8
Q

Overall percentage of patients with obstructive CAD?

A

37% (prevalence)

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9
Q

What was the percentage of obstructive CAD in women studied?

A

26%

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10
Q

Name of study demonstrating percentage of findings in elective cardiac catheterization?

A

Low Diagnostic Yield of Elective Coronary Angiography; NEJM 2010; Patel, et al.

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11
Q

Corus CAD sensitivity in PREDICT?

A

85%

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12
Q

Corus CAD NPV in PREDICT?

A

83%

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13
Q

Corus CAD Positive predictive value in PREDICT?

A

46%

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14
Q

Corus CAD test specificity?

A

43%

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15
Q

When was the gender-specific analysis published?

A

2012

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16
Q

What was the prevalence of obstructive CAD in men?

A

47%

17
Q

What was the percentage of men and women with NO CAD?

A

18% of Men and 38% of women had no CAD

18
Q

In study: indicator of obstructive CAD in Women?

A

Corus CAD

19
Q

Indicator for obstructive CAD in Men?

A

Corus CAD, Typical Chest Pain, Age, Dyslipidemia

20
Q

Role of MPI was significant?

A

Not significant indicator in Men or Women

21
Q

Objective of 12 month PREDICT 12 month follow-up?

A

To evaluate if patients with a low CAD score have significant risk of Major adverse events @ 12 months

22
Q

What percentage of procedures and events occurred in first 30 days?

A

92% (267/292)

23
Q

How many patients were evaluated in the 12 month follow-up?

A

1116 (96% of original 1160)

24
Q

What is a “low” Corus CAD score in Predict?

A

Less than or equal to 15

25
Q

What MACE rate does a low Corus score have in this cohort @ 12 mos?

A

Less than 1% (NOT associated with the index coronary angio)

26
Q

What % of patients were revascularized within 12 months (including index coronary angiography) with a low CAD score?

A

9.1%

27
Q

What is MACE defined as in this cohort?

A

Stroke, TIA, MI, or all-cause death

28
Q

What is a “mid-range” CAD score in PREDICT?

A

16-27

29
Q

What is a “high” CAD score in PREDICT?

A

28-40

30
Q

What percentage of event rate and procedure rate was seen in the “high” CAD score group?

A

Nearly 40%

Three times that of the “low score” group.

31
Q

Why a score of 15?

A

This corresponded to 20% likelihood of CAD.

32
Q

What is “high probability of CAD in this study?

A

Framingham risk score of 20% (10 year likelihood of having event)

33
Q

What journal was this published in?

A

Annals of Internal Medicine

CardioDX-Predict (1 decks)

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