Precocious Puberty Flashcards
1
Q
Precocious Puberty Types
A
GnRH dependent (Complete, true)
GnRH independent (Incomplete, pseudo)
Premature thelarche
Premature adrenarche
2
Q
Activation of HPO axis
INCREASED FSH, E2 or testosterone, DHAS
A
GnRH DEPENDENT
Idiopathic
CNS lesion
Hypothyroidism
3
Q
Production of sex hormones
DECREASED FSH
INCREASED E2 or testosterone, DHAS
A
GnRH INDEPENDENT
Ovarian (i.e. GCT)
Adrenal McCune-Albright
Iatrogenic
4
Q
GnRH INDEPENDENT
Mutation in G3 protein activating adenylate cyclase
Constant stimulation of FSH, LH, TSH and GH
FIRST SIGN - VAGINAL BLEEDING
A
McCune Albright Syndrome
TRIAD:
Cafe au lait spots
Fibrous dysplasia
Cysts of skull and long bones
