Pre-eclampsia Flashcards

1
Q

Definition of pre-eclampsia

A

Presence of Pregnancy induced hypertension and pregnancy induced proteinuria which stops after delivery

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2
Q

Pathogenesis of pre-eclampsia:

A

Poor placentation in the first half of the pregnancy
Leads to the oxidatively stressed placenta in the second half of pregnancy
Dysfunctional maternal endothelium, increased systemic inflammatory response

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3
Q

Maternal crises of pre-eclampsia

A
Eclampsia
HELLP syndrome
Cerebral haemorrhage
Cortical blindness
ARDS
DIC
Oedema
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4
Q

Fetal crises of pre-eclampsia

A

Intrauterine asphyxia
Intrauterine death
Placental abruption

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5
Q

Possible Features of pre-eclampsia

A
PIH
Generalised oedema
Haemoconcentration
Increased haematocrit
Hyperuricaemia
Proteinuria
Hypocalciuria
Raised plasma creatinine
Reduced creatinine clearance
Raised AST, ALT
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6
Q

Maternal Risk factors for pre-eclampsia

A
Diabetes
Hypertension
Chronic renal disease
Obesity
PCOS
Previous pre-eclampsia
Family history
Antiphospholipid antibody syndromes
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7
Q

Fetal risk factors for pre-eclampsia

A

Trisomy
Hydatidiform mole
Multiple pregnancy
Placental hydrops

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8
Q

Antihypertensive drugs contraindicated in pre-eclampsia

A

ACE inhibitors

Angiotensin II inhibitors

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9
Q

Drugs used in pre-eclampsia

A

Labetalol

Nifedipine

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10
Q

ACE inhibitors
Angiotensin II inhibitors
Teratogenic

A

Growth restriction
Oligohydramnios
Intrauterine + post natal renal failure

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