Practise Qs

Question 1

T or F: Stalk cells:
A) are DLL4 positive
B) Contribute to lumenisation of the neovessel
C) Express higher markers of proliferation than other endothelial cells
D) Have reduced glycolysis compared with tip cells
E) Respire anaerobically

Answer 1

A) False
B) True
C) True
D) True
E) False

Question 2

Fill in the blanks:
Lymphatic vessels are _____ open in response to _____ interstitial pressure.
Proliferation and migration, in response to cytokines such as _____, result in _____.
Increased _____ and density of the lymphatic vasculature results in increased _____ into the _____ circulation.
This system permits interstitial fluid and _____ leukocytes to be returned into the circulation via _____ _____.

Answer 2

1) pulled
2) increased
3) VEGF-C
4) lymphangiogenesis
5) function
6) drainage
7) venous
8) educated
9) lymph nodes

Question 3

Which one of the following checkpoint inhibitors is currently being used clinically in the treatment of patients with cancer?
A) Anti-CD80
B) Anti-CD86
C) Anti-CD27
D) Anti-CTLA4
E) Anti-TCR

Answer 3

D) Anti-CTLA4

Question 4

T or F: The Angiopoietin-Tie axis:
A) signals quiescence and activation
B) is an endogenous agonist/antagonist system
C) Angiopoietin 2 is released by pericytes
D) signals result in AKT activation
E) is a G-protein coupled receptor

Answer 4

A) T
B) T
C) F
D) T
E) F