Practise Exam Qs

Question 1

Which of the following is not true:
TFs can recruit enzymes that:
A) methylate histones
B) alter nucleosome positioning
C) acetylate histones
D) methylate DNA
E) phosphorylate DNA

Answer 1

E)

Question 2

Alternative splicing occurs:
A) during transcription
B) after transcription
C) after constitutive splicing
D) in the cytoplasm
E) during cell division

Answer 2

A) during transcription

Question 3

In genome-wide studies, known SNPs (array based) explain _____% of the heritability in breast cancer, despite the evidence of greater than 30% heritability from twin and family studies

Answer 3

10-14%

Question 4

Fill in the blanks:
FoxA1 is a _____ transcription factor that binds to DNA and recruits _____ _____ and its associated co-factors.
Many TFs bind _____ weakly or not at all.
DNA methylation is associated with the _____ of transcription and it can also block the _____ TFs.
Transcription co-activators often _____ histone tails resulting in the recruitment of _____ _____ and the formation of ______.

Answer 4

1) pioneer
2 & 3) estrogen receptor
4) Heterochromatin
5) repression
6) binding
7) acetylate
8 & 9) bromodomain proteins
10) euchromatin