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MCB 3413 > Practice Set 6 > Flashcards

Practice Set 6 Flashcards

1
Q

Which of the following covalent modifications is not true?

A

H1 methylations are very important in opening chromatin.

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2
Q

Which of the following activities is not part of the chromatin remodeling mechanism?

A

Oxidation to H4.

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3
Q

Which of the following methods is used to analyze open chromatin structure?

A

DNA hypersensitivity with nuclease treatment.

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4
Q

Which of the following methods is used to detect genome-wide protein distribution on chromosome
regions?

A

ChIP.

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5
Q

In Drosophila, heterochromatin

A

All are correct

a. is condensed throughout the cell cycle.
b. contains very small number genes.
c. is located near the centromeres.

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6
Q

Epigenetics could cause gene silencing through

A

All are correct

a. DNA methylation
b. histone modification
c. non-coding RNA, e.g., miRNA, siRNA

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7
Q

Position effect variation

A

All are correct

a. is an epigenetic phenomenon.
b. involves no DNA sequence change
c. was shown originally by using a chromosome inversion

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8
Q

Which of the following describes the histones associated with the nucleosomes of active genes?

A

Rich in acetyl groups (i.e., hyperacetylated)

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9
Q

Compared to heterochromatin, euchromatin is

A

rich in genes and comprised of loosely packed nucleosomes.

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10
Q

The phenomenon in D. melanogaster known as Position-Effect Variegation (PEV) provides powerful evidence that:

A

chromatin structure is able to regulate gene expression.

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11
Q

In mice, the igf2 allele is only expressed if

A

it is inherited from the father.

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12
Q

Regions of a chromosome that are bundled in highly condensed chromatin are known as

A

heterochromatin.

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13
Q

A Barr body refers to

A

None are correct

a. a sex-linked trait in cats.
b. a recessive trait in fruit flies.
c. an inactivated Y chromosome.
d. spore formation in Neurospora.

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14
Q

“Traditional” Whole Genome Sequencing (WGS) employs which of the following techniques?

A

All are correct

a. The construction of genomic libraries
b. Cloning of DNA in bacterial systems
c. Sanger dideoxy DNA sequencing

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15
Q

Sanger DNA sequencing determines the nucleotide sequence because:

A

dideoxy nucleotides terminate the growing DNA strand.

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16
Q

Pyrosequencing determines the nucleotide sequence because:

A

PPi is released from the growing DNA strand.

17
Q

The TRANSCRIPTOME is defined as:

A

the sequence and expression patterns of all transcripts.

18
Q

Regarding genomic imprinting, which of the following statements is NOT true

A

It is an inheritance process of the classical Mendelian inheritance

19
Q

In mice the Igf-2 gene is maternally imprinted. To generate parthenogenic mice that inherited both Igf-2 alleles maternally, a genetic-engineering experiment was carried to

A

allow only one of the maternally derived alleles to express

20
Q

The phenotypical difference between the XX and XO genotypes can be best explained by

A

the XO genotype only has a single dose of genes located in two pseudoautosomal regions

21
Q

Regarding genomic imprinting, which of the following statements is NOT true

A

It is an inheritance process of the classical Mendelian inheritance

22
Q

In mice the Igf-2 gene is maternally imprinted. To generate parthenogenic mice that inherited both Igf-2 alleles maternally, a genetic-engineering experiment was carried to

A

allow only one of the maternally derived alleles to express

23
Q

Which of the following covalent modifications is NOT true?

A

H1 methylations are very important in opening chromatin.

24
Q

Which of the following activities is not part of the chromatin remodeling mechanism?

A

Oxidation to H4.

25
Q

Which of the following methods is used to analyze open chromatin structure?

A

DNA hypersensitivity with nuclease treatment.

26
Q

Which of the following methods is used to detect genome-wide protein distribution on chromosome
regions?

A

ChIP.

27
Q

In Drosophila, heterochromatin

A

All are correct
a. is condensed throughout the cell cycle.
b. contains very small number genes.
c. is located near the centromeres.

28
Q

Epigenetics could cause gene silencing through

A

All are correct

a. DNA methylation
b. histone modification
c. non-coding RNA, e.g., miRNA, siRNA

MCB 3413 (12 decks)

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