Practice Questions Flashcards
All of the following anti-seizure drugs block sodium channels EXCEPT:
A. Carbamazepine B. Divalproex C. Lamotrigine D. Topiramate E. Vigabatrin
E. Vigabatrin
Which of the following anti-seizure drugs would be most effective in a patient with absence seizures who also experiences complex partial seizures? A. Ethosuximide B. Phenobarbital C. Phenytoin D. Tiagabine E. Valproate
E. Valproate
Long-term use of CYP-inducing anti-seizure drugs is associated with a fat-soluble vitamin deficiency leading to which of the following adverse effects?
A. Hepatotoxicity B. Hypertension C. Osteopenia D. Renal insufficiency E. Weight loss
C. Osteopenia
Disproportionate increases in plasma levels can occur with small increases in the dose of one of the anti-seizure drugs? Which of the following is NOT an adverse effect of this drug?
A. Blood dyscrasias B. Hirsutism C. Rash/SJS D. Renal caliculi E. Teratogen
4-D
Which of the following adverse effects is a boxed warning for all anti-seizure drugs?
A. Blood dyscrasias B. Cognitive dysfunction C. Rash/SJS D. Suicidality E. Teratogen
D. Suicidality
Which of the following anti-seizure drugs can be used for management of manic episodes of bipolar disorder?
A. Valproate and carbamazepine B. Phenytoin and lorazepam C. Levetiracetam and lamotrigine D. Gabapentin and vigabatrin E. Topiramate and valproate
A. Valproate and carbamazepine
The on-off phenomenon in Parkinson’s disease is a limitation associated with treatment by which of the following drugs?
A. Amantadine B. Levodopa C. Pramipexole D. Selegiline E. Trihexyphenidyl
B. Levodopa
Pramipexole has the advantage compared to levodopa of having a lower incidence of which of the following side effects?
A. Compulsive gambling B. Dyskinesia C. Nausea D. Orthostatic hypotension E. Somnolence
B. Dyskinesia
Which of the following drug classes may be neuroprotective and prevent degradation of both endogenous dopamine and dopamine derived from administered levodopa?
A. COMT inhibitors B. D2 receptor agonists C. DOPA decarboxylase inhibitors D. MAO-A inhibitors E. MAO-B inhibitors
E. MAO-B inhibitors
Which of the following Parkinson’s disease drugs acts outside the CNS?
A. Carbidopa B. Entacapone C. Selegiline D. A and B E. A and C F. B and C
D. A and B
Which of the following symptoms of Parkinson’s disease is LEAST likely to show improvement after administration of levodopa-carbidopa? A. Akinesia B. Bradykinesia C. Postural instability D. Rigidity E. Tremor
C. Postural instability
Which of the following is the most serious side effect of drugs that treat the underlying causes of migraine headache?
A. Cardiovascular events B. Dependence C. GI irritation and bleeding D. Nausea and vomiting E. Postural hypotension
A. Cardiovascular events
Which of the following drugs would best provide short-term relief of pain in patients with episodic migraine who are not responsive to triptans or ergots?
A. Botulinum toxin B. Butorphanol C. Midrin D. Propranolol E. Valproic acid
B. Butorphanol
Which of the following drugs is capable of relieving nausea and vomiting associated with migraine but does not significantly alter GI motility?
A. Amitriptyline B. Butalbital C. Metoclopramide D. Prochlorperazine E. Sumatriptan
D. Prochlorperazine
Long-term use of which of the following migraine drugs is associated with pleural and cardiac valvular fibrosis?
A. Dihydroergotamine B. Frovatriptan C. Metoclopramide D. Midrin E. Sumatriptan
A. Dihydroergotamine
Which of the following drug classes is most likely to interact with a triptan to cause serotonin syndrome?
A. Beta blocker B. CYP3A4 inhibitor C. D2 receptor antagonist D. MAO inhibitor E. NSAID
D. MAO inhibitor
Drugs that bind to the benzodiazepine (BZD) binding site on the GABA-A receptor are called:
A. Allosteric agonists B. Antagonists C. Barbiturates D. Full agonists E. Partial agonists
A. Allosteric agonists
A patient being prepared for a surgical procedure is given a short-acting drug to manage their anxiety. Which of the following drugs can be used to reverse the effect of this drug?
A. Flumazenil B. Lorazepam C. Midazolam D. Naloxone E. Phenobarbital
A. Flumazenil
All of the following substances are considered non-selective CNS depressants EXCEPT:
A. Butalbital B. Ethanol C. General anesthetics D. Methohexital E. Zolpidem
E. Zolpidem
Which of the following drugs will have the LEAST intense symptoms of withdrawal if abruptly discontinued? (assume all were given at comparable doses for the same amount of time)
A. Alprazolam B. Flurazepam C. Lorazepam D. Temazepam E. Triazolam
B. Flurazepam
Which of the following statements about flumazenil is INCORRECT?
A. It has a short half-life.
B. It is a BZD receptor antagonist.
C. It reverses the hypnotic effect of eszopiclone.
D. It can cause seizures in patients on long-term therapy with BZDs.
E. It precipitates withdrawal in patients dependent on barbiturates.
E. It precipitates withdrawal in patients dependent on barbiturates.
A drug whose duration of action is dependent on redistribution from one compartment of the body to another is:
A. Alprazolam B. Buspirone C. Butalbital D. Methohexital E. Phenobarbital
D. Methohexital
Which of the following is NOT an advantage of buspirone in the treatment of anxiety as compared to BZDs?
A. No rebound anxiety B. Rapid onset of action C. Does not affect motor skills D. No additive effect with ethanol E. Little sedative or euphoric effects
B. Rapid onset of action
Which of the following drugs does not act on GABA-A receptors to produce its intended therapeutic effect?
A. Buspirone B. Suvorexant C. Zolpidem D. A and B E. A and C F. B and C
D. A and B
Name the dopamine pathway that is involved in the anti-emetic effect of dopamine D2 receptor antagonists.
A. Tuberoinfundibular
B. Medullary-periventricular
C. Nigrostriatal
D. Mesolimbic-mesocortical
B. Medullary-periventricular
Which of the following drugs is a partial agonist of dopamine D2 receptors?
A. Aripiprazole B. Chlorpromazine C. Olanzapine D. Quetiapine E. Risperidone
A. Aripiprazole
Long-term use of which of the following drugs is associated with arrhythmias in patients with preexisting cardiovascular disease?
A. Chlorpromazine B. Clozapine C. Haloperidol D. Lithium E. Ziprasidone
D. Lithium
Which of the following receptors is targeted by atypical antipsychotics to account for their efficacy against the negative symptoms of schizophrenia?
A. D2 B. 5-HT2A C. 5-HT3A D. 5-HT1A E. M3
B. 5-HT2A
A patient undergoing long-term treatment with an atypical antipsychotic is most likely to develop which of the following disorders?
A. Depression B. Diabetes C. Dyskinesia D. Hyperprolactinemia E. Neuroleptic malignant syndrome
B. Diabetes
All of the following drugs or drug classes are recommended in the treatment of bipolar disorder EXCEPT:
A. Antidepressants B. Antipsychotics C. Anti-seizure drugs D. Benzodiazepines E. Lithium
A. Antidepressants
