Practice Questions Flashcards

1
Q

A decrease in the neuronal uptake of an injected dose of NE occurs after administration of

A. reserpine
B. tyramine
C. Cocaine
D. botulinum A
E. A MOAI
A

C. Cocaine (blocks )

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2
Q

If an animal is pretreated with atropine, which will antagonize the BP increase caused by acetylcholine?

A. Scopolamine
B. Propranolol
C. Metoprolol
D. Physostigmine
E. Mecamylamine
A

E. Mecamylamine

- blocks ganglionic transmission

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3
Q

A group of rats has been treated with a drug that causes lethargy and hypotension. Chemical analysis of the adrenal medulla reveals that the Epi content is only 20% of normal. you deduct that the drug the rats have been treated with is

A. tyramine
B. botulinum toxin
C. cocaine
D. reserpine
E. prazosin
A

D. reserpine

- depletes catecholamines from adrenergic nerves

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4
Q

the increase in BP after a large dose of Ach can be reversed by

A. mecamylamine
B. botulinum toxin
C. atropine
D. propranolol
E. neostigmine
A

A. mecamylamine

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5
Q

a new drug has been shown to cause profuse sweating. the effect of the drug can be mimicked stimulating sympathetic nerves to the sweat glands but cannot be blocked by an adrenergic receptor antagonist. the reason is that the drug is

a. a muscarinic receptor agonist
b. a muscarinic receptor antagonist
c. a nicotinic receptor antagonist
d. an a-1 adrenergic receptor agonist
e. an inhibitor of NE re-uptake

A

a. a muscarinic agonist

- sweat glands are the only sympathetic effectors that contain muscarinic receptors

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6
Q

The injection of Ach intravenously produces an immediate fall in bp followed by an increase in bp. the prior administration of mecamylamine prevents the increase in blood pressure. the rise in bp is primarily due to

A. potentiation of NE release by cholinergic presynaptic receptors
B. inhibition of NE secretion from sympathetic nerves innervating heart
C. stimulation of muscarinic receptors on vascular smooth muscle
D. release of NO from endothelial cells
E. secretion of NE from sympathetic nerves innervating vasculature

A

E. secretion of NE from sympathetic nerves innervating the vasculature

  • baroreceptor reflex activation of SNS
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7
Q

You have obtained secretions from a tumor derived from neural tissue. removal of the tumor resulted in a decrease in mean BP of 30 mmHg. the cells show a + stain for choline acetyltransferase and dopamine beta-hydroxylate but not PNMT. you determine that the NT secreted from the tumor that is associated with the increase in bp is probably

A. eli
B. l-dopa
C. dobutamine
D. Ach
E. NE
A

E. NE

  • lack of PNMT indicates that it is NE not Epi
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8
Q

Drug X increases BP and alertness but decreases appetite. Prior treatment with drug Y eliminates these effects of drug X. Drug Y is

A. amphetamine
B. phenylephrine
C. reserpine
D. mecamylamine
E. NE
A

C. reserpine

  • depletes catecholamines from adrenergic nerves
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9
Q

Epi and NE are released into the circulation in response to stressful circumstances. the release of these catecholamines can be blocked by prior treatment with

A. atropine
B. physostigme
C. an alpha adrenergic receptor antagonist
D. a beta adrenergic receptor antagonist
E. mecamylamine
A

E. mecamylamine

  • ganglionic blocking drug
  • block post-synaptic activation of sympathetic nerves
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10
Q

Administration of NE activates the baroreceptor system resulting in no change or a reduction in HR. Pretreatment with drug A reveals the ability of NE to increase HR. Drug A is

A. reserpine
B. cocaine
C. propranolol
D. metoprolol
E. atropine
A

E. atropine

  • blocks muscarinic receptors in heart that are normally activated by baroreceptor reflex
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11
Q

Treatment of an animal with drug A lowers BP. this agent also decreases the effect of cocaine. Drug A is most likely

A. nicotine
B. reserpine
C. ACh
D. botulinum toxin
E. mecamylamine
A

B. reserpine

  • depletes catecholamines from adrenergic nerve endings
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12
Q

Synthesis of Ach is regulated by

A. presynaptic muscarinic receptors
B. uptake to choline into nerve
C. choline acetyltransferase
D. presynaptic a2 adrenergic receptors
E. synthesis of acetylCoA
A

B. uptake of choline into nerve

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13
Q

A large dose of ACh given to an anesthetized animal can increase BP. This effect can be prevented by prior administration of

A. physostigmine
B. botulinum toxin 
C. mecamylamine
D. atropine
E. propranolol
A

C. mecamylamine

- block nicotinic ganglionic receptors

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