Practice Q

Question 0

How is Hammett substitution constant measures

Answer 0

Examining ionisation equilibria of benzoic acids

Question 1

How is substituents hydrophobicity constant calculated?

Answer 1

Experimental measure log p for a standard compound (eg benzene) and substituted compound
PI= logpx - logph

X in comparison to hydrogen

Question 2

Ionisation equilibria (K)=

Answer 2

Conc Ions / conc unionised

Question 3

Equate for sigma

Answer 3

Sigma = log Kx/kh

K is dissociation constant for x or h

Question 5

How to determin es?

Answer 5

Examine effects of substituents on rate of standard reaction (acid hydrolysis)

Question 6

Define comb chem

Answer 6

Techniques for producing large numbers of compounds in a short period of time, using defined reaction routes and a large variety of starting materials and reagents

Question 7

What is the solid approach to comb chem

Answer 7

attach one of the starting materials (first amino acid) to an insoluble support material (a “resin bead”)

Question 11

What is ko with regards to calculating es

Answer 11

Rate of hydrolysis of methyl ethanoate (tafts standard)