Practical 2 Flashcards
1
Q
Effect of low calcium concentration
A
Nerve stimulation decreases rapidly
2
Q
Effect of high calcium concentration
A
High levels of nerve stimulation which leads to more Ach release
3
Q
Effect of high magnesium concentration
A
- Twitch tension decreases
- Action of Ach on end plate is blocked
- Magnesium competes with calcium and blocks release of Ach
4
Q
Effect of tubocurare
A
Nerve response decreased as tubocurare competes with Ach
5
Q
Effect of atropine
A
No effect on nerve stimulation as acts on muscarinic receptors not nicotinic
6
Q
Effect of TTX
A
Decreased nerve stimulation and muscle stimulation
7
Q
Effect of suxamethonium
A
Twitch tension decreases - competes for same receptors as Ach
8
Q
Effect of neostigmine
A
Increased nerve stimulation. Competes for attachment to acetylcholinesterase so increases Ach available
