PPT Flashcards
what class of drug is adrenaline?
alpha- and beta-adrenergic agonists
what is the mechanism of action of adrenaline?
Acts on both alpha and beta receptors and increases both heart rate and contractility (beta1 effects); it can cause peripheral vasodilation (a beta2 effect) or vasoconstriction (an alpha effect).
what are the indications for adrenaline?
CPR – 1mg every 3-5 mins
Acute hypotension (children)
Emergency treatment of acute anaphylaxis – IM injection 500mcg
Bradycardia control in patients with arryhmias post MI
what are the adverse effects of adrenaline?
Adverse effects – gangrene if injected in fingers
Hypertension – leads to cerebral haemorrhage
Tachycardia, palpitation, angina, arrythmia
what are the contraindications of adrenaline?
Contraindications – injection around finger/toe, hypertension, CHD, arrythmia, haemorrhagic shock, thyrotoxicosis
what class of drug is amiodarone?
class III antiarrythmic
what class of drug is atropine?
antimuscarinic
what class of drug is 8.4% sodium bicarbonate?
an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
what class of drug is Calcium gluconate or Calcium chloride?
mineral supplement
what class of drug is Magnesium sulfate?
anticonvulsant, a cathartic, and an electrolyte replenisher
what is the mechanism of action of amiodarone?
-blocks potassium currents that cause repolarization during the third phase of the cardiac action potential.
- increases the duration of the action potential and refractory period for myocytes, reducing cardiac muscle cell excitability preventing and treating abnormal heart rhythms
also interferes with beta receptors, sodium and calcium channels
what is the mechanism of action of atropine?
Atropine binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects.
what is the mechanism of action of 8.4% sodium bicarbonate?
systemic alkaliser, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis.
It is also a urinary alkaliser, raising the urinary pH.
what is the mechanism of action of Calcium gluconate or Calcium chloride (hyperkalaemia)?
Calcium increases the threshold potential, thus restoring the normal gradient between threshold potential and resting membrane potential, which is abnormally elevated in hyperkalemia. Onset of action is within 5 minutes, and duration of action is about 30-60 minutes
what is the mechanism of action of Magnesium sulfate (hypomagnesaemia, Torsades de pointe, digoxin toxicity)?
dd
what are the indications for amiodarone?
d
what are the indications for atropine?
d
what are the indications for 8.4% sodium bicarbonate?
metabolic acidosis and hyperkalaemia
what are the indications for Calcium gluconate or Calcium chloride (hyperkalaemia)?
d
what are the indications for Magnesium sulfate (hypomagnesaemia, Torsades de pointe, digoxin toxicity)?
d
what are the adverse effects of amiodarone
d
what are the adverse effects of atropine
d
what are the adverse effects of 8.4% sodium bicarbonate (metabolic acidosis and hyperkalaemia)?
d
what are the adverse effects of Calcium gluconate or Calcium chloride (hyperkalaemia)?
d
what are the adverse effects of Magnesium sulfate (hypomagnesaemia, Torsades de pointe, digoxin toxicity)?
d
what are the contraindications for amiodarone?
d
what are the contraindications for atropine?
d
what are the contraindications for 8.4% sodium bicarbonate (metabolic acidosis and hyperkalaemia)?
d
what are the contraindications for Calcium gluconate or Calcium chloride (hyperkalaemia)?
d
what are the contraindications for Magnesium sulfate (hypomagnesaemia, Torsades de pointe, digoxin toxicity)?
d
name some local anaesthetics?
Lidocaine
Bupivacaine
what drug class is lidocaine
d
what drug class is bupivacaine
d
what is the mechanism of action of lidocaine?
d
what is the mechanism of action of bupivacaine?
d
what are the indications of lidocaine?
d
what are the indications of bupivacaine?
s
what are the adverse effects of lidocaine?
n
what are the adverse effects of bupivacaine?
j
what are the contraindications of lidocaine?
d
what are the contraindications of bupivacaine?
nd
name some IV general anaesthetics?
Etomidate
Ketamine
Propofol
Thiopental
name some IV opioids used in general anaesthesia?
Fentanyl
Remifentanil
name some inhalational general anaesthetics?
Desflurane Halothane Isoflurane Nitrous oxide Sevoflurane
what is the mechanism of etomidate?
m
what is the mechanism of ketamine?
j