PPT

Question 1

first line Tx Parkinson’s when motor Sx affecting pt’s QOL?

Answer 1

levodopa

Question 2

first line Tx Parkinson’s when motor Sx are not affecting pt’s QOL?

Answer 2

dopamine agonist, levodopa or MAO-Bi

Question 3

which anti-parkinsons drugs cause the most improvement in motor Sx?

Answer 3

levodopa

Question 4

which anti-parkinsons drugs cause the most improvement in ADLs?

Answer 4

levodopa

Question 5

which anti-parkinsons drugs cause the most motor complictions?

Answer 5

levodopa

Question 6

which anti-parkinsons drugs have more off-time reaction?

Answer 6

dopamine agonists

Question 7

which Parkinson’s drugs are the highest risk o hallucination?

Answer 7

dopamine agonists

Question 8

which pts are more at risk of impulse control disorders?

Answer 8

dopamine agonist therapy
a history of previous impulsive behaviours
a history of alcohol consumption and/or smoking

Question 9

which drug can be considered if excessive daytime sleepiness develops secondary to Parkinson drugs?

Answer 9

modafinil

Question 10

which drug can be considered if orthostatic hypotension develops secondary to Parkinson’s drugs?

Answer 10

midodrine

Question 11

what can be considered to manage drooling of saliva in people with Parkinson’s disease?

Answer 11

glycopyrronium bromide

Question 12

what are the 2 common types of levodopa given?

Answer 12

carbidopa or benserazide (co-benldopa and co-careldopa)

Question 13

wha is levodopa always combined with and why?

Answer 13

nearly always combined with a decarboxylase inhibitor (e.g. carbidopa or benserazide)
this prevents the peripheral metabolism of levodopa to dopamine outside of the brain and hence can reduce side effects

Question 14

common adverse effects of levodopa

Answer 14

dry mouth
anorexia, N&V
reddish discolouration of urine upon standing
palpitations
postural hypotension
psychosis
end-of-dose wearing off
on-off phenomenon
dyskinesias at peak dose

Question 15

examples of dopamine receptor agonists used for parknsons

Answer 15

bromocriptine, ropinirole, cabergoline, pramipexole

Question 16

SE of dopamine agonists?

Answer 16

impulse control disorders
excessive daytime somnolence
halluinations
nasal congestion
postural hypotension

Question 17

examples of COMTi?

Answer 17

entacapone, tolcapone

Question 18

example of MAO-Bi?

Answer 18

selegiline
rasagiline

Question 19

MOA sodium valproate?

Answer 19

increase GAB activity

Question 20

MOA carbamazepine?

Answer 20

Binds to sodium channels increasing their refractory period

Question 21

moa lamotrigine?

Answer 21

sodium channel blocker

Question 22

moa of phenytoin?

Answer 22

Binds to sodium channels increasing their refractory period

Question 23

moa of orphendrine?

Answer 23

antimuscarinic

Question 24

moa of vigabatrin?

Answer 24

GABA transaminase inhibitor

Question 25

moa of gabapentin?

Answer 25

gaba analogue

Question 26

moa of pregabalin

Answer 26

gaba analogue

Question 27

moa of topiramate?

Answer 27

glutamate receptor antagonist

Question 28

moa of ethosucimide?

Answer 28

neuronal calcium channel block

Question 29

moa of triptans?

Answer 29

serotonin 5HT1B/1D agonist

Question 30

moa of donopezil?

Answer 30

selective reversible inhibitor of acetylcholinesterase

Question 31

moa of galantamine

Answer 31

selective reversible inhibitor of acetylcholinesterase

Question 32

moa of rivastigmine

Answer 32

selective reversible inhibitor of acetylcholinesterase

Question 33

moa of memantine

Answer 33

NMDA receptor antagonist

Question 34

what do levodopa interact with?

Answer 34

MAOi general anaesthetics antihypertensives

Question 35

liquid calculation

Answer 35

(what you want / what youve got) x volume its in

Question 36

what does 1 in 1000 mean?

Answer 36

1 in 1000ml