PPP EOR Topics Flashcards
Most common presentation of PAD
Intermittent claudication
Leriche’s syndrome
Thigh or buttock claudicayiob, impotence, decreased femoral pulses
Livedo reticularis
Mottling of skin
Bruits in a peripheral vessel indicate occlusion is this bad
50% occlusion
ABIs with PAD
Normal 1-1.2
PAD <0.90
Severe PAD < 0.50
Rest pain/limb ischemia <0.4
*ABI of at least 0.85 needed to heal ulcers in diabetics
Thx of intermittent claudication
Cilostazol
Where do most AAAs occur?
Infrarenally
At what size is AAA rupture more likely?
> 5cm
Which bp med should a pt with an AAA be on to prevent aneurysm growth?
BB
When is immediate surgical intervention indicated for an AAA?
> 5.5cm or >0.5cm expansion in 6 months
Describe monitoring/referral guidelines for AAAs <5.0cm
3-4cm US annually
4-4.5cm US every 6 months
>4.5cm vascular surgery referral
Where do most aortic dissections occur?
65% in ascending
Most important predisposing factor for aortic dissection (present in 80% pts)
Hypertension
Sudden onset of severe tearing ripping knife-like chest pain
Aortic dissection
DeBakey classification of aortic dissection
Type I originate in ascending and propagates distally
Type II isolated to ascending
Type III originates in descending and propagates proximally
Stanford aortic dissection classification
A - involves ascending aorta and/or aortic arch
B - isolated descending aorta
Trousseau syndrome
Migratory thrombophlebitis associated with malignancy
Tx of superficial thrombophlebitis
Supportive with extremity elevation, warm compressed, NSAIDs and elastic supportive compression stockings
Asymmetric calf swelling >3cm should make you think of this
DVT
Cerulea alba
Milky white pallor with occlusion of deep venous system
Cerulea dolens
Cyanosis and swelling of limb with sudden pain associated with superficial and deep venous system compression
Antidote for heparin toxicity
Protamine sulfate
If someone has a VTE what is the minimum time frame to treat with anticoagulants?
3 months
Compare and contrast skin changes in peripheral venous v. Arterial dz
Venous-stasis dermatitis, brownish pigmentation, edema
Arterial- atrophic changes such as thin shiny skin, loss of hair thick nails, pallor, dry skin, livedo reticularis(mottled appearance)
Cheyne-Stokes
Smooth increases in respiration’s followed by gradual decrease and apnea
Caused by hypercapnia
Biot’s breathing
Quick shallow breaths of equal depth followed by a period of apnea
Seen with brain stem damage and opioid use
Kussmaul’s respirations
Deep rapid continuous respirations
Associated with metabolic acidosis
Vomiting/NG SUCTION, chronic diarrhea, and loop diuretics cause this kind of acid base imbalance
Metabolic alkalosis
Normal blood pH
7.35-7.45
> 7.45 alkalosis
<7.35 acidosis
Normal Pco2
35-45
Normal HCO3
22-26
Parietal cells secrete ________ and are stimulated by ______, _______, and ________.
HCl
Gastrin
Histamine
Ach/vagus nerve
Most common cause of noncardiac chest pain
GERD
Lifestyle modifications for GERD
Elevate head of bed 6in
Avoid recumbent for 3hr postprandiallly
Small meals
Avoid spicy/acidic/caffeine foods
Smoking cessation
Compare and contrast dysphasia in achalasia, esophageal webs/rings, and esophageal neoplasm
Achalasia- doilies and liquids
Webs/rings- solids
Neoplasms-solids progressing to liquids
MC type of hiatal hernia
Sliding/type I
Lab testing for Zollinger-Ellison syndrome
Fasting gastrin > 1000pg
Increased gastrin release with secretin administration
Linitis plastica
Diffuse thickening of stomach wall due to gastric cancer infiltration
Dubin-Johnson syndrome
Hereditary decreased hepatocyte excretion of conjugated bilirubin
Dubin, Direct bilirubinemia, Dark glossy liver
No treatment needed
Crigler-Najjar syndrome
Hereditary indirect hyperbilirubibemia
phototherapy may be needed in neonates if severe presentation
Describe biliary colic
Episodic abrupt RUQ/epic Astrid pain that resolves slowly lasting 30min-hrs
Lab marker of hepatocellular carcinoma
Alpha feta protein
Common causes of actue pancreatitis
Gallstones and ETOH
Scorpion nite more common in SW
Abd and back pain better with leaning forward, new onset DM, painless jaundice, weight loss, courvoisier’s sign
Pancreatic carcinoma
MC in head of pancreas. Poor 5yr survival rate, most pass by 6mo
Colon dilation >6cm and signs of systemic toxicity
Toxic megacolon
Toxic megacolon etiology
UC, CD, pseudomembranous colitis, infection, radiation, ischemia
Toxic megacolon management
DECOMPRESSION
bowel rest, electrolyte depletion, Bria’s spect abx?
Colostomy only for refreactory cases
Opioid agonist got to of diarrhea
Diphenoxulate/atropine (lomitil)
Loperamide
Serotonin receptor blocker antiemetics
Ondansteron
Granistron
Dolasteron
Dopamine blocker antiemetics
Procholorperazine
Promethazine
Metoclopramide
Bulk forming laxitives
Psyllium
Methylcellulose
Polycarbophil
Wheat dextran
Osmotic laxatives
Polyethylene glycol
Lactulose
Sorbitol
Milk of magnesia
Stimulant laxitives
Biscodyl
Senna
Describe the hypothalamus-pituitary-thyroid axis
Hypothalamus releases TRH which stimulates pituitary to release TSH which stimulates the thyroid to release T3 and T4
Describe the hypothalamus-pituitary-adrenal axis
Hypothalamus releases CRH stimulating pituitary to release ACTH which stimulates the adrenal glands to secrete cortisol
Describe the hypothalamus-pituitary-gonadal
The hypothalamus secretes GnRH, which stimulates the pituitary to secrete FSH and LH with stimulates release of testosterone, estrogen and progrsterone from gonads
Pituitary adenoma
Cushings dz
Labs go in _____________ direction when the problem is the target organ
Opposite
Cold intolerance, weight Gavin with decreased appetite, dry thickened skin, loss of outer 1/3 eyebrow, hypoactivity, constipation, hoarseness, bradycardia and pericardial effusion
Hypothyroidism
Heat intolerance, weight loss with increased appetite, hyperactivity, diarrhea, tachycardia, HF
Hyperthyroidism
Tx for thyroid storm
IV PTU or methinmazole
BB for symptoms
IV glucocorticoids
Cooling blankets
(AVOID ASA)
Tx for myxedema coma
IV levothyroxine
Passive warming
Pretoria last myxedema is associated with
Grave’s disease
SE of both PTU and methimazole
Agranulocytosis
Toxic adenoma often presents with these type of symptoms
Compressive sx
Dyspnea, dysphasia, strider, hoarseness
Painful tender thyroid with elevated ESR
De quervain’s/granulomatous thyroiditis
Medications that cause thyroid issues
Amiodarone, lithium, alpha interferon
Risk factor for development of a thyroid nodule
Hx of year or neck irradiation
MC type of thyroid nodule
Follicular adenoma(colloid)
> 90% are benign
Cold thyroid nodules on RAIU should make you suspicious for this
Malignancy
MC and least aggressive type of thyroid carcinoma
Papillary = popular
Local cervical mets common
Type of thyroid carcinoma associated with distant Mets
Follicular
Thyroid cancer associated with MEN2 and calcitonin secretion
Medullary
Worse prognosis/ most aggressive for thyroid cancer, may invade trachea making a tracheostomy necessary
Anaplastic
MC cause of primary hyperparathyroidism
Parathyroid adenoma (80%)
Will occur in 20% of pts taking lithium
MC cause of secondary hyperparathyroidism
CKD
MEN 1 is associated with this
Hyperparathyroidism
Pituitary tumors
Pancreatic tumors
MEN 2A is associated with this
Hyperparathyroidism
Pheochromocytoma
Medullary thyroid carcinoma
Clinical manifestation and dx of hyperparathyroidism
Stones, bones, abd groans, and psych moans
Decreased DTR
Hypercalcemia, elevated PTH, low phosphate, elevated urine Ca
Osteopenia on bone scan
Adrenal aldosteronoma
Cobb’s syndrome
Primary hyperaldostetonism leading to hypokalemia and hypertension
Tx for Conn’s syndrome
Excision if mass and spironolactone
Dx studies suggestive of Conns
Hypokalemia with metabolic acidosis (u wave on ekg)
ARR >20
Plasma aldosterone >20
Management of pheochromocytoma
Complete adrenalectomy
Phenoxybenzamine of phentolamine followed by bb