PPO2 Flashcards
ARCUS
Type, Mechanism, Layer, Prevalence, Mgmt
Degeneration
STROMA
60% (40-60), 90% (70-90)
No mgmt
Abnormals - serum lipid profile (young/thick)
LIMBAL GIRDLE OF VOGT
Type, Mechanism, Layer, Prevalence, Mgmt
Degeneration
SUB EPI collagen (UV)
60% (40-60), 90% (70-90)
No mgmt
HUDSON-STAHLI LINE
Type, Mechanism, Layer, Prevalence, Mgmt
Degeneration
BOWMAN’S
20% (20’s), 60% (60’s)
No mgmt
DECEMET’S STRIAE
Type, Mechanism, Layer, Prevalence, Mgmt
Degeneration
DESCEMETS
Normal unless large - (+) pachymmetry stromal edema
No mgmt
MOSAIC SHAGREEN
Type, Mechanism, Layer, Prevalence, Mgmt
Degeneration
STROMA
Normal unless trauma - (+) pachymmetry stromal edema
No mgmt
HASSAL HENLE BODIES + GUTTATA
Type, Mechanism, Layer, Prevalence, Mgmt
Degeneration
Henle - peripheral, Guttata - central
Raised bits of DECEMETS into endothelium, stroma
70% (40’s)
No mgmt unless pigment, edema, fuchs - (+) pachymmetry stromal edema
CORNEAL FARINATA
Type, Layer, Prevalence, Mgmt
Degeneration
STROMA lipofusin
Normal bproduct of age
No mgmt
SALZMANN’S NODULAR DEGEN
Type, Mechanism, Layer, Prevalence, Mgmt
Degeneration
Rare ~old keratitis, mucopolysaccharides, osteoporosis, pterygium
Plaque between EPITHELIUM + BOWMAN’s
Mgmt:
monitor yearly, if (+) epithelial breakdown:
rewetting drops, mytomycin C, PTK
BAND KERATOPATHY
Type, Mechanism, Layer, Prevalence, Mgmt
Degeneration
Gray calcium/phosphate salts 3/9oclock
STROMA
Normal in elderly, unless longstanding inflamm/glaucoma/hyperPTH/RA/vit D toxicity
No mgmt unless above:
serum Ca/Mg levels, Uric acid (gout), N2, Creatinine, ACE (sarcoid)
Va affected = chelating agent + scraping
DELLEN
Type, Mechanism, Layer, Prevalence, Mgmt
Rare Finding
Thinning cornea next to raised area
STROMA
Mgmt: TREAT to prevent scar/neo, remove cause, lubricate
KAYSER-FLEISCHER RING
Rare finding - WILSON’S D+ copper ring
DECEMETS
Mgmt: REFER to internist, low Cu+ diet
Kayser-Fleisher Ring
Rare finding - WILSON’S D+ copper ring
DECEMETS
Mgmt: REFER to internist, low Cu+ diet
PANNUS
Normal finding in small amounts Limbal vessels 1-2mm (micro), 2< (gross) Mgmt: FIND CAUSE micro - conj, staph bleh, CL wear, acne roseaca gross - (+) trachopa, atopic keratoconj
POSTERIOR EMBRYOTOXIN
Congenital finding, Rare = glaucoma
DESCEMETS (Schwalbe’s line)
Mgmt: DDX GLAUCOMA
IOP, gonio, iris/corneal changes
KRUCKENBERG SPINDLES
Abnormal finding
ENDOTHELIUM
Mgmt: DDX GLAUCOMA
IOP, gonio, iris transillumination, PXE/PDS
VORTEX KERATOPATHY
Other finding EPITHELIAL+STROMA Mgmt: Drugs (plaquenil/amiodarone) = normal Fabry's D+ = abnormal - refer for enzyme replacements
FLEISCHER’S RING
Fe ring at base of cone in keratoconus
FERRY LINE
Fe ring around filtering blep
STOCKER’S LINE
Fe at the head of pterygium
COAT’S RING
Fe around FB
AXENFELD LOOPS
loop of nerve from anterior ciliary body ~12% eyes
OCULARMELANOSIS
extra pigment in the eye
EPICAPSULAR STARS
remnant of TUNICA VASCULOS LENTIS. star shaped distn of brown flecks on anterior capsule
Y SUTURE
anterior Y, posterior flipped
ZONULAR OPACITIES
embryonic opacity affecting only innermost lens
CORNEAL SCAR
injruy to Bowman’s/Stroma
CORNEAL SCAR
injruy to Bowman’s/Stroma
3 types of corneal dystrophies
keratoconus, fuch’s dystrophy, epithelial/BM disorders
3 Hallmarks of Keratoconnus
irregular astigmatism, apical protrusion, paracentral stromal thinning
Munson’s sign
keratoconus - convexivity of lower lid on downgaze
Fleischer’s ring
keratoconus - Fe at base of cone
Vogt’s striae
keratoconus - vertical striae posterior stroma
Corneal hydrops
keratoconus - due to breaks in decemets membrane. Decrease vision, cause pain, edema in stroma. T(X) cycloplegics + hypertonics
Mechanism of keratoconus?
- unable to eliminate ROS/NO- = oxidative damage
- poor collagen x-linking = Bowman’s fibrillates
- causes epi to be in contact with stroma
T(X) keratoconus?
glasses
rgp’s, scleral CL’s, piggyback lenses*
corneal x-linking (riboflavin + UV)*
keratoplasty (transplant)
Prevalence of Fuch’s Epithelial Endothelial dystrophy?
Autosomal dominant, slow progression, bilateral, females
Ocular signs of Fuch’s dystrophy?
Early - guttata: change sin endo due to dec ability to act as a pump
Progression - stromal edema, corneal scarring, epithelial edema, bullous keratopathy
Complications of Fuch’s?
2˚ glaucoma - same mechanism that destroys endo prob destroys trabecular meshwork
T(X) fuch’s?
Hairdryer in morning
5% NaCl hypertonic drops, ointment at night
BCL’s
PTK for corneal scarring
Decemet stripping automated endothelial keratoplasty (DSAEK) in severe cases
Prevalence of Epithelial BM dystrophy
40’s to 70’s, women
Causes of epithelial BM dystrophy?
Problems with the BM: thickening causes Epi to unadhere from stroma = melformed hemidesmosome connections
4 ocular findings of epithelial BM dystrophy?
dots (microcysts in epithelium)
fingerprints (projections of BM into epi)
maps (thick BM overlying epi)
blebs (mounts of granular tissue bw bowman’s + BM)
best way to view findings of epithalial BM dystrophy?
direct retro for opacifications in corneal epithelium and BM!
Complications of epithelial basement membrane dystrophy?
Increase chance of erosion
Epithelial BM Dystrophy T(X)
No S(X) = monitor DE = lubricate Erosions = ointment, pressure patch, NaCl- agents PTL on Bowman's to help healing
Loss of Corneal claricity is caused by 4 things
NISE
neo, injury, scarring, edema
How long for epithlium to regen?
24-48 hrs, total cycle is 7-14 days
How long for BM to regen?
6-8 days
Where does neo happen = loss of claricity
Surface + Stroma
Diff between surface + stromal neo?
Superficial neo - tight CL’s, trachoma, superior limbal keratitis
Deep stromal neo - infection, usually Syphilis, TB, mumps, interstitial keratitis
5 symptoms of corneal injury
PPHVL Pain Photophobia Halos dec VA Lacrimation
Causes of corneal injury
abrasion, bullous keratopathy, trauma
DDx Ulcer vs Abrasion
Ulcer = (+) history, pain, wbc’s, epithelium and stroma, takes up NaFl
Abrasion = epithlium, NaFl stays in would, red, no discharge
How do you T(x) a corneal abrasion?
antibiotics + cycloplegia
How do you treat a recurrent corneal erosion?
pressure patch, scrape epi to improve healing, BCL
How do you treat a FB in the cornea?
irrigate, alger brush, then treat as if abrasion (lub, BCL’s, antibiotics, cyclo)
Explain epithelial edema
Cause: PMMA’s, rbcs,abrasion, swimming, scatters light >5%
Sign: sclerotic scatter = dark
S(X): dec VA, halos, spec blur
Mgmt: hypertonic NaCl, hair dryer, lower IOP, remove cause
Explain stromal edema
Cause: Soft CL’s, Fuch’s, surgical, trauma, ulcers, IOP, glaucoma
S(X): glare
Mgmt: pachymetry, DSAEK, steroids
8 layers of the lid
eyelashes, skin, vasculature, muscles, grey line, orbital septum, tarsal plate, conjunctiva
Glands in the eyelashes
glands of moll (sweat), glands of zeiss (sebaceous)
innervation to eyelid
orbicularis oculi (CN7) - close shut
muellers (SNS) - tonic elevation
levator (CN3) - open
Where are the glands of moll?
eyelashes
Where are the glands of zeiss?
eyelashes
where are the meibomian glands?
tarsal plate
Components of anterior lid
eyelashes, skin, vasculature, muscles, grey line
components of posterior lid
tarsal plate, conjunctiva
dividing line of the lid
physical: orbital septum
surgical: gray line
Poliosis
whitening of the lashes
Trichiasis
Misdirection of the lashes
Madarosis
Partial loss of lashes
Alopecia
complete loss of lashes
lid coloboma
congenital abnormality
gaps in lid
congenital
oculoplasty
epicanthal folds
congenital abnormality
autosomal dominant in asians
DDX: pseudo-ET
oculoplasty
distichiasis
extra row of lashes instead of meibomian glands
rare autosomal dominant
FB trackstaining inferior cornea
T(X): BCL, epilation, electrolysis, chyrotherapy (N2)
blepharophimosis
small lid fissures
~ epicanthal folds/levator not working
autosomal dominant
oculoplasty
blepharochalasis
idiopathic acute lid swelling
when D+ quiet, oculoplasty
dermatochalasis
redundant skin, thin, loss of elasticity normal in elderly causes dry eye, pseudoptosis DDX: pseudoptosis T(X): blepharoplasty
ectorpion
eyelid eversion, puncta displaced, reflex tearing, inferior hyphema
due to: congenital, involutional, paralytic, idiopathy, acoustic neuroma, hcronic allergies, mechanical
T(X): surgery, AT/lube, BCL
Entropion
eyelid inversion, tearing, FB sensation, irritation
find track staining, trichiasis
cause: age, congenital, spastic
T(X): surgery, AT, BCL, remove lashes (epilation, electrolysis, chryotherapy)
Congenital ptosis
(+) history, lack tarsal fold
~ marcus gunn jaw winking syndrome (V/III)
- damae to CN3
Acquired ptosis
(-) history, (+) tarsal fold
-trauma, horner’s, cn3 palsy diabetes
Testing a ptosis
hold frontalis muscle, measure movement up and down (8-15mm)
Grade;
mild - top edge of pupil
mod - 1-2mm down
severe - halfway or more covering pupil
Nevus
benign, flat, congenital, uniform pigmentation.
Document
Papilloma
Benign lid lesion
upward proliferation of epithelial cells.
Elevated, focal lesions, smooth, non-infectious
Caused by UV
MGMT: doc, monitor, surgery, bichloracetic acid
Xanthelasma
yellow raised deposits, bialteral women
Doc, medically evaluate, surgery, serum cholesterol profile maybe
Pseudoriferous cyst
plugged gland of Moll - clear fluid
focal elevation, taut surface
T(X): excision with drainage, (+/- prophylactic antibiotic)
Sebaceous cyst
plugged Meibomian gland - yellow fluid
focal elevation, taut surface
T(X): excision with drainage, (+/- prophylactic antibiotic)
Basal cell carcinoma
lower, medial, insidious same color as skin slow growing, non-metastisizing progresses laterally = dip in the middle - nodular, ulcerative, sclerosing, multicentric
T(X) basal cell carcinoma
biopsy, excision (mohr’s technique), frozen section surgery, radio-therapy, cryosurgery
staph blepharitis - difference bw acute and chronic appearance
acute: sudden uni–> bilateral
inflammed margins, collarettes at base, lids stuck in the morning, hyperemic conj
chronic: (+) history, rosettes, ulceration of lid margins, lids stuck often
T(X) acute staph blepharitis vs chronic staph bleph
acute: hot compress 10min, lid scrubs (5:1) bidx2weeks, antibiotics (topical bid 1 week)
chronic: everything (+) throw out makeup, (+) broadspectrum antibiotics, (+) steroid if inflammed, (+) pulse treatment
Seborrheic blepharitis
dandruf-like collarettes suspended on lashes
oily looking
NO INFLAMMATION
alcoholics - zinc sulphate
T(X): lid scrubs, hot compress, broad antibiotics if combined with staph
Meibomian gland dysfunction
dry eye, inflamed margins, capped orifices, dry eye
lid hygiene, hot compress, express glands with Q tip
external hordeolum
staph infection @ gland of Zeiss
acute inflamm = HOT, RED, TENDER, ELEVATED
sudden onset with pus point
T(X) hot compress to accelerate infection
prophylaxis antibiotics bid 1 week
internal hordeolum
staph infection @ meibomian glands
acute inflamm = HOT, RED, TENDER, ELEVATED
T(X) hot compress to accelerate infection
prophylaxis antibiotics bid 1 week
DDX pre-septal cellulitis
-infection has spread to anterior lid (+) oral antibiotic
DDIX pre-septal cellulitis vs orbital cellulitis
Orbital septus has decreased vision, decreased EOMs, narrow fissure. OCULAR EMERGE!
hordeolum vs chalazion
hordeolum: HOT, ELEVATED, TENDER, RED, INFALMMED. ACUTE
chalazion: H(X) of previous infection, not tender or hot, slow onset, progressively enlarging
chalazion
noninfections, non inflammatory SLOW onset chronic, reoccuring focal internal lesion NOT WARM/TENDER progressively enlarges
MGMT: hot compress
biopsy/excision (DDX sebaceous cell carcinoma)
DDX internal hordeolum
T(X): steroid injection to get rid of inflamm components
demodex
8-legged
tubular sleeve of collarettes at BASE of lashes
1. brevis - sebaceous gland
2. follicularum - hair follicle
S(X): itchy in the MORNING, BURNING, SORE lids
T(X): remove excess, smother in ointment + steroids, confirm: 4 lashes > 6 demodex
Phthiris Palpebraum
6-legged, darker, longer
S(X): itchy ALL DAY, rubbing, burning
T(X): a/b steroid qid 1 week, come back after 2 days, remove nits, contact family doctor
Molluscum contagiosum
DNA Pox virus
-follicualr conjunctivitis
certain size, stays there, cheesy appearance
T(X): cauterization when D+ quiet, self-dissolving, excision
Verruca
HPV, broccoli looking appearance, multilobulated (vs papilloma)
S(X): painless
T(X): cauterization, self dissolving
Contact dermatitis
allergic reaction - conjunctivitis (follicular)
S(X) swelling, red, eventually flakey, itchy, epiphora, red
T(X) determine allergin, cold compresses, topical steroid, antihistamines
Conjunctival follicles
pink, watery, elevated, shiny bumps “blistery”
Causes - hypersensitivity, viral conjunctivitis
T(X) - resolves on own.. find cause
Conjunctival papillae
red, bumpy dilated vessels (PMN’s, wbc’s)
Causes - bacterial, CL wear, allergic, prosthesis
T(X) - find cause
Retention cyst
clear vacuole like, spherical, interpalpebral space, asymptomatic
Cause - cellular degen due to DE
T(X) - lancing
Xerosis
yellow opaque, flat keratinization on bulbar conj
S(X) severe dry eye + night blindness
Cause: vitamin A deficiency
T(X): lubrication, treat deficiency
Pinguecula
UV = fibrovascular degeneration Mechanical rubbing (CL's)
surgery, wear sunscreen, lubricate
Pterygium
Flsehy, vascularizaed trnagular growth, apex on cornea, destroy’s BOWMAN’s layer caused by UV
S(X) blurry vision, FB sensation, diplopia, DE
Stocke’s line: Fe at head of pterygium
T(X): remove + beta radiation 1xweek/3weeks
Concretion
Small yellow-white opaque deposits due to age/degeneration + allergies
S(X) FB sensation, asymptomatic
T(X) loosen with Q tip
Adenochrome deposits
Black deposits found on lower side that are reversible. Acquired secondary due to glaucoma meds NE
MGMT: doc, monitor
Melanoma
A/B/C? asymmetrical, bleeding, color? vascularized.
from nevus or spontaneously due to UV. REFER!
Subconj heme
S(X): painless, upserficial, bleeds laterally, aviods limbus
Due to coughing, trauma, birth, medication (blood thinner)
MGMT: TRAUMA H(X)? check ant seg - workup VA, SLE, Pupils, EOMs, IOP, DFE
Broad signs of conjunctivitis
- BV dilation = red + hyperemia
- Cellular infiltrates (wbc’s and exudates)
- Edema = chemosis
- Discharge (watery or mucopurulent)
- Papillae (bacterial)
- Follicles (viral)
- Pre-aurricular nodes (viral)
- Cornea involvement
- Collarettes (bacterial)
Acute Bacterial Conjunctivitis
Unilateral to bilateral in 2-3 days, H(X)?
S(X) - lashes matted in morning, red, no pain
Causes - s. aureus/epidedermis, strep, h. influenza
Signs:
-mucopurulent discharge
-hyperemic bulbar conj @ FORNIX
-palpebral papillae dark red
-cornea +/- SPK @ BOTTOM / FOCAL
-scrape/smear = (+) PMN’s
- (-) pre-auricular node
Treat acute bacterial conjunctivitis?
discard makeup
lid scrubs
warm compress
topical broad spectrum antibiotic
if non resolving… compliance? cultures? sensitivity? second opinion..
Chronic bacterial conjunctivitis
usually accompanies corneal + lid inflammation
S(X): burning, FB, (+) H(X)
Signs:
-Lids (tyalosis, madarosis, poliosis, collarettes)
-Lumps/Bumps (hordeolum, chalazion)
-Cornea (PERIPHERAL SPK + SEI**)
- (-) pre-auricular node
Two types of adenoviruses
Pharyngoconjunctival fever (PCF) + Epidemic keratoconjunctivitis (EKC)
Pharngyoconjunctival fever
DNA adenovirus
S(X): red eye, discharge, uni–> bilateral, fever, sore throat
Signs: follicles, watery, no collarettes, smear = lymph, cornea = CENTRAL SEI, DIFFUSE SPK
(+) pre-auricular nodes
pseudomembranes
T(X) cold compresses, H(X)
Epidemic keratoconjunctivitis
DNA adenovirus S(X) malaise, tired, fever, unilateral --> bilateral Signs: week of 7 week1: -acute follicular conjunctivitis -discharge --> pseudomembrane -diffuse hyperemia -watery -smear = lymph -cornea = diffuse SPK -(+) preauric nodes week2: elevated lesions (-) NaFl week3: central SEI
Treating EKC
remove pseudomembrane
cold compresses
topical steroids for SEI when VA is down (Pregnenalone)
Betadine - offuse 4-5 drops 1 min, wash off
Treating Sub-epithlial infiltrates
Steroids ie pregnenalone acetate
tapered:
qidx1week, bidx3days, qidx2 days, etc
SPK in chronic bacterial infections vs acute/hyperacute?
acute = top/bottom focal SPK chronic = peripheral SPK
SPK in bacterial infections vs viral?
bacterial = focal SPK
viral + chronic bacterial conj= diffuse SPK
Herpes Zoster is caused by what virus
Varicella virus (Shingles)
Signs of herpetic viral conjunctivitis
- unilateral vesicular eruption
- ophthalmicus nerve
- hutchingson’s sign: 40% chance if involves nose will involve eye
- viral signs: (+) chemosis/water/preaur node
- cornea (+) SPK (+) PSEUDODENDRITES (rose bengal)
- uveitis
- trabeculitis (2˚ glauc)
- episcleritis
- INCREASED CORNEAL sensitivity
Treatment of herpetic viral conjunctivitis
- atlernative meds ie acupuncture
- oral antivirals = Acylovir 5xweek 7-10days
- preventative: zostavax vaccine
- steroids for anti-inflammation
Jones test
Patency bw puncta + inf meatus (blow nose test/q-tip)
Regurgitation test
Patency bw puncta + nasolac sac (squeeze sac and water back thru puncta)
Tear prism
tear volume - look at lid margin - tear meniscus height should be 0
phenol red thread test
tear volume - normal is 10mm in 15s
shirmer’s test
tear volume - with/without anesthetic
TBUT
tear stability <5mm (little)
SPK - few cells damaged
punctate erosions - lots of areas
geographic areas - huge
Mires
Non-invasive TBUT
measures when mires distort
abnormal <10s
Lactoferrin immunological test system
Osmolarity test
Abnormal if ring doesn’t increase in size
Biomarker analysis
Osmolarity - increased = the goblet cells are affected
Line of marx
tear film analysis - mucocutaneous, border moves anterior, thicker, irregular
Meibomian expression
Lipid layer measure
-no inflamm
apply stable force to mimic blink
Cause + Mgmt: Punctum Stenosis
age/inflamm - surgery probing
Cause + Mgmt: Punctum eversion
age/inflamm - surgery
Cause + Mgmt: Stenosis of canaliculus
age/inflamm - surgery, probing, antibiotics if infection*, warm compresses
Cause + Mgmt: Dacryocystitis
infection/inflamm of lac sac SECONDARY TO OBSTRUCTION/INFECTION
-unilateral
DDx internal hordeolum/chalazion
-infants - wait 6mo-1 year for probing antiobiotics
Mechanism Allergic Dry eye
INFLAMM = goblet cell death = DE
Mechanism Blepharitis-causing Dry eye
EVAPORATION = impaired lipid layer
- anterio bleph = staph bleph/seborrheic bleph
- posterior bleph = meibomian gland disfunction
Mechanism eye drops causing Dry eye
INFLAMM = cytotoxic PT’s damage mucin/goblet cells
Mechanism Viral conjunctivitis
INFLAMM = cytokines damage mucin/goblet cells
Some causes of dry eye? and Mechanism?
EVAPORATION + INFLAMM
CL’s, Environment
aging, Aging, Hormones (androgens dec inflamm)
systemic D+ sjogren’s, RA, Graves, Gout
Meds: anti HT, anti H, preservatives (BAK)
Treating Dry eye
NPAT/AT Warm compresses 10min Lid scrubs 5:1 Blinking exercises Punctal occlusion NSAIDs (Restasis + Lotemax)
Artificial Tears for DE
help only with S(X)
tear vol replensihment + stabilization
protect cornea
dec osmolarity
corticosteroids for DE
antiinflammatory (taper)
NSAIDS for DE
Restasis(immunosuppressant) + Lotemax(steroid) day 1: lotemax prn day 14: lotemax bid + restasis bid day 60: restasis bid 6mo: monitor progression
Punctal occlusion for DE
1-2mm down, collagen or silicone
maskin probes for DE
evacuate meibomian glands
When would you R(X) a small prescription?
Adults - task specific, antimetropia
How much change in cyl can an adult tolerate?
15˚ axis, 0.75D
Rules of myopes and presbyopes in prescribing?
don’t take away minus frm myope or NN from presbyope (NN = D + Add)
Children <5 how do you prescribe
bold + caution. Amblyopia vs emmetropization
Aniso Iso H >1 >5 A >3 >8 M >1.5 >2.5
How much anisometropia induces vertical phoria?
> 1.0 D in DOWNWARD GAZE
Aniseikonia’s experience vertical phoria where?
all gazes.. play with BC, centre thickness, n, aspherics
How much antimetropia induces vertical phoria?
0.5 D
Anisophoria: their NVP is 10cm
OD = -5.00sph
OS = -2.00 sph
How much prism should be put on glasses and what eye?
F(OD = 5(0.1) = 0.5∆ BD OD aka 0.5∆ R. hypophoria
Therefore.. 0.5∆ BU OD
or, 0.25 BU OD + 0.25 BD OS
Malingering
figure out their goal.. want glasses? $? attn?
Clinical hysteria
psychological acute stress/trauma
R/O organic pathology
Reassure
Refer to psychologist
Streff (Non-malingering)
kids 8-18
Bilateral loss at distance + near (with Rx)
reassure
refer
Dispenasary hocus focus
vague complaints about glasses/Rx that don’t make sense cuz of external factors
Munchausen (by proxy) syndrome
Attn munching!
MANDATED report + refer for mental health