PPI Proton Pump Inhibitor

Question 1

What is the specific action of a Proton Pump Inhibitor (PPI)?

Answer 1

Blocks basal and stimulated acid production & reduces gastric acid secretion by irreversibly stopping the enzyme that produces gastric acid.

Question 2

PPIs medication name end in what suffix, which is a good way to identify the medication type?

Answer 2

ZOLE

Question 3

What is the therapeutic use for a PPI?

Answer 3

Short-Term therapy for Gastric & Duodenal ulcers, erosive esophagitis & Gastric Reflux disease ( GERD). Also for the prevention of stress ulcers for at risk patients experiencing acute events

Question 4

What are complications or adverse reactions from PPIs?

Answer 4

Pneumonia, Osteoporosis & Fractures, (decreased acid can lead to decreased calcium) Low magnesium for long -time use

Question 5

What are contraindications for PPIs?

Answer 5

Liver disease & dysphagia (difficulty swallowing)

Question 6

What are medications interactions?

Answer 6

Digoxin, methotrexate, diazepam, antifungal agents, ( while on PPis the digoxin & phenytoin ( dilantin) levels can increase

Question 7

What are nursing administration and teaching precautions about PPIs?

Answer 7

Do not crush, chew, or break time-release capsules, Do not open & sprinkle over food, take omeprazole once per day prior to eating in the morning, Active Ulcers are treated for 4-6 weeks, Observe & notify for any indication of occult GI bleeding as evidenced by coffee-ground emesis.