PPI Flashcards

1
Q

Omnigenic traits

A

idea that any regulatory gene variant in a specific tissue is likely to have weak effects on multiple traits or diseases influenced by that tissue.

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2
Q

Network Pleiotropy

A

single genetic variant may affect multiple traits, not because they are directly connected, but because they are mediated through same cell types, or regulated through same networks.

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3
Q

Extreme Pleiotropy

A

Single genetic variance or set, influence multiple, seemingly unrelated traits or processes.

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4
Q

Difference between Omnignenic Traits and Network Pleiotropy

A

OT (equifinality) - many genes influencing one trait; NP (multifinality) interconnected effect of single variant on multiple traits.

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5
Q

Extreme Pleiotropy vs. Network

A

Both (multifinality) - Network highlights pathways, Extreme highlights rage of traits affected.

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6
Q

Goals

A

Cognitive Representations of end states interconnected to means of attainment.

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7
Q

Self-Regulation

A

Process by which people set goals and attempt to attain them

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8
Q

Successful self-regulation

A

acting in accordance with ones goals

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9
Q

Goal activation

A

Selection of actions and resource mobilization towards goal advancement

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10
Q

Transfer of affect

A

Behavior that may initially be neutral/ aversive become desirable in the absence of original motivation

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11
Q

Goal-conflict resolution

A

Goal representations activate at the same time, leading individuals to seek multifinal means of satisfying multiple goals simultaneously

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12
Q

Goal shielding

A

People inhibit weaker alternatives in favor of prioritized goals

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13
Q

Motivated Distortion

A

Result of goal shielding; Active distortion of information relevant to goal pursuit to align with current motivational state.

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14
Q

Attentional Bias

A

momentarily heightened accessibility to drug leads to inhibition of alternative concens.

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15
Q

Big 5

A

Emotional stability; Extraversion; Openness; Agreeableness; Consciousness

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16
Q

Rich get richer hypothesis

A

people who are sociable and have strong relationships, high self esteem and low social anxiety show most benefit of internet use

17
Q

Compulsive Internet Use

A

Continued use despite intention to stop; internet dominates cognition and behaviors; Withdrawal - unpleasant emotions when internet use is not possible; using internet to escape from negative feelings; conflicts arise due to internet use.

18
Q

Prosocial behavior

A

Any voluntary act meant to benefit another

19
Q

Behavioral Coherence/ Heterotypic continuity

A

continuity of an inferred trait that is presumed to underlie diverse phenotypic behaviors

20
Q
A